Epilepsy pp 29-40 | Cite as

Epidemiology of Epilepsy

  • David W. McCandless


The epidemiology of epilepsy varies worldwide, with age, sex, comorbidities, ­overall health, reporting schemes, definitions, etc. It was once stated that “the object of any science is the accumulation of systematized verifiable knowledge, achieved through observation, experimentation, and thought”


Status Epilepticus Cerebral Malaria Febrile Seizure Seizure Type Dizygotic Twin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Dube, C., et al. (2000) Prolonged febrile seizures in the immature rat model enhance hippocampal excitability in limbic circuits. Nat. Med. 5:888–894Google Scholar
  2. Hill, A. (1953) Observation and experiment. New Eng J Med 248:995–1001PubMedCrossRefGoogle Scholar
  3. Shamansky, S., and Glaser, G. (1979) Socioeconomic characteristics of childhood seizure disorders in the New Haven area: an epidemiological study Epilepsia 19:457–474Google Scholar
  4. Camfield, C., et al. (1996) Incidence of epilepsy in childhood and adolescence: a population based study in Nova Scotia from 1977–1985 Epilepsia 37:19–23Google Scholar
  5. Annegers, J., et al. (1999) The incidence of epilepsy and unprovoked seizures in multiethnic urban health maintenance organization Epilepsia 40:502–506Google Scholar
  6. Zarrelli, M., et al. (1999) The incidence of epileptic syndromes in Rochester Minnesota Epilepsia 40:1708–1714Google Scholar
  7. Bharucha, N. (2003) Epidemiology of epilepsy in India Epilepsia 44:9–11Google Scholar
  8. Sridharan, R., and Murthy, B. (1999) Prevalence and pattern of epilepsy in India Epilepsia 40:631–636Google Scholar
  9. Gambhir, S., et al. (1995) Public awareness understanding, and attitudes towards epilepsy. Ind. J Med Res 102:34–38Google Scholar
  10. Maremmani, C., et al. (1991) Descriptive epidemiological study of epilepsy syndromes in a district of northwest Tuscany, Italy Epilepsia 32:294–298CrossRefGoogle Scholar
  11. Benn, E., et al. (2008) Estimating the incidence of first unprovoked seizure and newly diagnosed epilepsy in the low income urban community of Northern Manhattan, New York City Epilepsia 49:1431–1439Google Scholar
  12. Adelow, C., et al. (2009) Newly diagnosed single unprovoked seizures and epilepsy in Stockholm, Sweden. Epilepsia 50:1o95-1101Google Scholar
  13. Vespa, P., and Nuwer, M. (2000) Post traumatic seizures CNS drugs 13:129–138Google Scholar
  14. Vespa, P., et al. (1997) Incidence of nonconvulsive and convulsive seizures in the ICU following traumatic brain injury Crit Care Med 1:A120Google Scholar
  15. Annegers, J et al. (1980) Seizures after head trauma: a population study Neurology 30:683–689Google Scholar
  16. Kollevold, T (1976) Immediate and early cerebral seizures after head injuries. I. J. Oslo City Hosp. 26:99–114Google Scholar
  17. Dawson, R., Webster, J., and Gurdjian, E. (1951) Serial electroencephalography in acute head injury J Neurosurg 8:613–630Google Scholar
  18. Lhatoo, S., and Sander, J. (2001) The epidemiology of epilepsy and learning disorder Epilepsia 42:6–9Google Scholar
  19. Alberman, E. (1984) Epidemiological aspects of severe mental retardation. In: Dobbing, J., et al. Scientific studies in mental retardation. London: Royal Soc. Med. Pp 3–13Google Scholar
  20. Rodin, E. (1968) Prognosis for seizure control. In Rodin, E., ed, The prognosis of patients with epilepsy. Springfield Illinois, Char. Thomas pp 179-262Google Scholar
  21. Forsgren, L., et al. (1996) Influence of epilepsy on mortality in mental retardation: an epidemiological study Epilepsia 37:956–963Google Scholar
  22. Ferro, J., and Pinto, F. (2004) Poststroke epilepsy Drugs Aging 21:639–653CrossRefGoogle Scholar
  23. Schreiner, A., et al. (1995) Epileptic seizures in subcortical vascular encephalopathy J Neurol Sci 130:171–177Google Scholar
  24. Giroud, M., et al. (1994) Early seizures after acute stroke: a study of 1640 cases. Epilepsia 35:959–964PubMedCrossRefGoogle Scholar
  25. Labovitz, D, Hauser, W., and Sacco, R. (2001) Prevalence and predictors of early seizure and status epilepticus after first stroke Neurology 57:200–206Google Scholar
  26. Arboix, A., et al. (1997) Predictive factors of early seizures after acute cerebrovascular disease Stroke 28:1590–1594Google Scholar
  27. Bladin, C., et al. (2000) Seizures after stroke: a prospective multicenter study Arch Neurol 57:1617–1622Google Scholar
  28. Kessler, K., et al. (2002) Reduced inhibition within primary motor cortex in patients with poststroke focal motor seizures Neurology 59:1028–1033Google Scholar
  29. Faught, E. (1999) Epidemiology and drug treatment of epilepsy in elderly people Drugs Aging 15:255–269Google Scholar
  30. Luhdorf, K., Hensen, L., and Plesner, A. (1986) Epilepsy in the elderly: incidence, social function and disability. Epilepsia 27:135–141PubMedCrossRefGoogle Scholar
  31. Tinuper, P., et al. (1996) Partial epilepsy of long duration: changing semiology with age Epilepsia 37:162–164Google Scholar
  32. Sharma, K. (2005) Genetic epidemiology of epilepsy: a twin study Neurol India 53:93–98Google Scholar
  33. Berkovic, S., et al. (1993) Twin birth is not a risk factor for seizures Neurology 43:2515–2519PubMedGoogle Scholar
  34. WHO (1978) Application of advances in neurosciences for control of neurological disorders. Tech Report Series 629:9–20Google Scholar
  35. Ngoungou, E., and Preux, P. (2008) Cerebral malaria and epilepsy Epilepsia 49:19–24Google Scholar
  36. McCandless, D. (2011) Jaundice in malaria. In Kernicterus. D. McCandless, ed., Springer, New York, NY. pp 121-132Google Scholar
  37. Carter, J., et al. (2004) Increased prevalence of epilepsy associated with severe falciparum malaria in children Epilepsia 45:978–981Google Scholar
  38. Ngoungou, E., et al. (2006) Epilepsy as a consequence of cerebral malaria in an area in which malaria is endemic in Mali, West Africa Epilepsia 47:873–879Google Scholar
  39. WHO (2004) Malaria incidence estimates at country level for the year 2004-proposed estimates and draft report Geneva, Roll Back Malaria. WHOGoogle Scholar
  40. Winawer, M., and Shinnar, S. (2005) Genetic epidemiology of epilepsy or what do we tell the families? Epilepsia 46:24–30PubMedCrossRefGoogle Scholar
  41. Anderson, V., and Hauser, W. (1997) Genetic counseling. In Engel, J and Pedley, T. eds. Epilepsy: A comprehensive textbook Phila. Lippincott-RavenGoogle Scholar
  42. Annegers, J., Hauser, W., and Anderson, V. (1982) The risks of seizure disorders among relatives of patients with childhood onset epilepsy Neurology 32:174–179Google Scholar
  43. Lennox, W. (1951) The heredity of epilepsy as told by relatives and twins Jam Med Assoc 146:529–536Google Scholar
  44. Winawer, M., et al. (2003) Evidence for distinct genetic influences on generalized and localization related epilepsy Epilepsia 44:1176–1182Google Scholar
  45. Welty, T. (2006) Juvenile myoclonic epilepsy Pediatr Drugs 303:303–310Google Scholar
  46. Hauser, W. (2001) Epidemiology of epilepsy in children. In Pellock, J. et al. Pediatric epilepsy diagnosis and treatment New York Demos pp 81-96Google Scholar
  47. Neville, B., Chin, R., and Scott, R. (2007) Childhood convulsive status epilepticus: epidemiology., management and outcome. Acta Neurol Scand 115:21–24PubMedCrossRefGoogle Scholar
  48. Chin, R., et al. (2006) Incidence, cause, and short term outcome of convulsive status epilepticus in childhood: prospective population based study Lancet 368:222–229PubMedCrossRefGoogle Scholar
  49. Chin, R., Neville, B., and Scott, R. (2004) A systematic review of the epidemiology of status epilepticus. Eur J Neurol. 11:800–810PubMedCrossRefGoogle Scholar
  50. Raspall-Chaure, M. et al. (2007) The epidemiology of convulsive status epilepticus in children: a critical review. Epilepsia 48:1652–1663PubMedCrossRefGoogle Scholar
  51. Adachi, N., et al. (2005) Intellectual prognosis of status epilepticus in adult epilepsy patients: analysis with Wechsler Adult Intelligence Scale-revised. Epilepsia 46:1502–1509PubMedCrossRefGoogle Scholar
  52. Maytal, J., et al. (1989) Low morbidity and mortality of status epilepticus in children. Pediatrics 83:323–331PubMedGoogle Scholar
  53. Rosenow, F., Hamer, H., and Knake, S. (2007) The epidemiology of convulsive and nonconvulsive status epilepticus. Epilepsia 48:82–84PubMedCrossRefGoogle Scholar
  54. DeLorenzo, R. (2006) Epidemiology and clinical presentation of status epilepticus. Adv. Neurol. 97:199–215PubMedGoogle Scholar
  55. Dura-Tave, T., Yoldi-Petri, M., and Gallinas-Victoriano, F. (2008) Panayiotopoulos syndrome: epidemiological and clinical characteristics and outcome. Eur J neurol 15:336–341CrossRefGoogle Scholar
  56. Ferrie, C., et al. (1997) Early onset benign occipital seizure susceptibility syndrome. Epilepsia 38:285–293PubMedCrossRefGoogle Scholar
  57. Singh, G., and Prabhakar, S. (2008) The association between CNS infections and epilepsy: Epidemiological approaches and microbiological and epileptological perspectives. Epilepsia 49:2–7PubMedCrossRefGoogle Scholar
  58. Annegers, J., Rocca, W., and Hauser, W. (1996) Causes of epilepsy: contributions of the Rochester epidemiology project. Mayo Clin Proc 71:570–575PubMedCrossRefGoogle Scholar
  59. Hesdorffer, D., et al. (1998) Risk of unprovoked seizure after acute symptomatic seizure: effect of status epilepticus. Ann Neurol. 44:908–912PubMedCrossRefGoogle Scholar
  60. Schuchat, A., et al. (1997) Bacterial meningitis in the United States in 1995. N. Eng. Med. 337:970–976CrossRefGoogle Scholar
  61. McDonald, S. (2000) Exploring the cognitive basis of right hemisphere pragmatic language disorders Brain and Language 75:82–107Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • David W. McCandless
    • 1
  1. 1.The Chicago Medical School Department of Cell Biology and AnatomyRosalind Franklin UniversityChicagoUSA

Personalised recommendations