Abstract
Autism was first described in 1943 by Kanner (1943). This landmark paper detailed 11 children whose “condition differs so markedly and uniquely from anything reported so far, that each case merits… a detailed consideration of its fascinating peculiarities.” Kanner saw symptoms which included an inability to relate to others, unusual responses to the environment, stereotyped motor mannerisms, odd communication peculiarities, and a tendency to echo language. Kanner saw only one case of epilepsy in his cohort of 11 patients. The case reports by Kanner are notable for their thoroughness of clinical description.
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References
Shinnar, S., et al. (2001) How long do new onset seizures in children last? ANN Neurology 49:659–664
Filipek, P., et al. (1999) The screening and diagnosis of autistic spectrum disorders J. Autism Dev Disorders 29:437–482
Courchesne, E., et al. (1988) Hypoplasia of cerebellar lobules VI and VII in infantile autism. N Eng J Med 318:1349–1354
Bachevalier, J., and Merjanian, P. (1994) The contribution of medial temporal lobe structures in infantile autism in Bauman, M., et al. eds. The Nerobiology of autism. Johns Hopkins Univ. Press pp 119-145
Gabis, L., Pomeroy, J., and Andriola, M. (2005) Autism and epilepsy: cause, consequence, comorbidity, or coincidence? Epil. Behav. 7:652–656
Trevethan,E. (2004) Seizures and epilepsy among children with language regression and autistic spectrum disorders. J. Child. Neurol. 19: S49-S57
Tuchman, R. (2004) AEDs and psychotropic drugs in children with autism and epilepsy. Ment. Retard. Dev. Disabil. Res. Rev. 10:135–138
Kanner, L. (1943) Autistic disturbances of affective contact. Nerv. Child. 2:217–250
Tuchman, R., and Rapin, I. (2002) Epilepsy in autism. Lancet Neurol. 6:352–358
Wiznitzer, M. (2004) Autism and tuberous sclerosis J. Child Neurol 19:738–748
Hunt, A., and Dennis, J. (1987) Psychiatric disorder among children with tuberous sclerosis. Dev. Med. Child. Neurol. 29:190–198
Jambaque, I., et al. (1991) Neuropsychological aspects of tuberous sclerosis sclerosis in relation to epilepsy and MRI findings. Dev Med Child Neurol 33:698–704
Danielsson, S., et al. (2005) Epilepsy in young adults with autism: A prospective population based follow up study of 120 individuals diagnosed in childhood. Epilepsia 46:918–923
Olsson, I., Steffenburg, S., and Gillberg, C. (1988) Epilepsy in autism and autistic like conditions Arch Neurol 45:666–668
Camfield, C., et al. (1993) Outcome of childhood epilepsy: a population based study with a simple predictive scoring system for those treated with medication. J. Pediatr 122:861–868
Canitano, R., Luchetti, A., and Zappella, M. (2005) Epilepsy, electroencephalographic abnormalities, and regression in children with autism. J Child Neurol 20:27–31
Commission on Classification and Terminology of the International League Against Epilepsy (1989) Proposal for revised classification of epilepsies and pileptic syndromes. Epilepsia 30:389–399
Tuchman, R. (2000) Treatment of seizure disorders and EEG abnormalities in children with autistic spectrum disorders. J Autism Dev Disord 20:485–489
Shinnar, S., et al. (2001) Language regression in childhood Pediatric Neurology 24:183–189
Aldred, C., Green, J., and Adams, C. 2004) A new social communication intervention for children with autism: pilot randomized controlled treatment study suggesting effectiveness. J Child Psychol Psychiatr 45:1420–1430
Wong, V., et al. (2006) Tuberous sclerosis complex: correlation of MRI findings with comorbidities J Child Neurol. 21:99–105
Curatolo, P., and Cusmai, R. (1987) Autism and infantile spasms in children with tuberous sclerosis Dev Med Child Neurol 29:190–198
Stobbe, G., et al. (2006) Use of levetiracetam in children with autism spectrum disorders and EEG epileptiform abnormalities Epilepsia 47:S4-S5
Canitano, R. (2007) Epilepsy in autism spectrum disorders Eur Child Adol Psychiatry 16: 61–66
Fombonne, E. (2003) Epidemiological surveys of autism and other pervasive developmental disorders: an update J Autism Dev Disord 4:365–382
Saemundsen, E., et al. (2007) Autism spectrum disorders In children with seizures in the first year of life-a population study Epilepsia 48:1724–1730
Moretti, P., et al. (2008) Brief report: autistic symptoms, developmental regression, mental retardation, epilepsy, and dyskinesias in CNS folate deficiency 38:1170–1177
Kothur, K., Ray, M., and Malhi, P. (2008) Correlation of autism with temporal tubers in tuberous sclerosis complex Neurol India 56: 74–76
Curatolo, P., et al. (2004) Autism in tuberous sclerosis Eur J pediatr Neurology 8:327–332
Bolton, P., and Griffiths, P. (1997) Association of tuberous sclerosis of temporal lobes with autism and atypical autism Lancet 349:392–395
Zuddas, A., et al. (2002) Neuroepileptic determinants of autism spectrum disorders in tuberous spectrum disorders in tuberous sclerosis complex Brain 125:1247–1255
Saemundsen, E., Ludvigsson, P., and Rafnsson, V. (2008) Risk of autism spectrum disorders after infantile spasms: a population based study nested in a cohort with seizures in the first year of life. Epilepsia 49:1865–1870
Fatemi, S., et al. (2009) GABAa receptor downregulation in brains of subjects with autism J Autism Dev Disord 39:223–230
Blatt, G., et al. (2001) Density and distribution of hippocampal neurotransmitter receptors in autism: an autoradiography study J Autism Dev Disord 31:537–544
Camfield, C., et al. (1993) Biologic factors as predictors of social outcome of epilepsy in intellectually normal children: a population based study J Pediatr 122:869–873
Shinnar, S., et al. (2001) Neuroimaging abnormalities in children with an apparent first unprovoked seizure Epil Res 43:261–269
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McCandless, D.W. (2012). Epilepsy and Autism. In: Epilepsy. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0361-6_24
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