Abstract
Status epilepticus is one of the true medical (neurological) emergencies. Convulsive as well as nonconvulsive status epilepticus can affect epileptic patients with essentially all forms of seizures from absence seizures to tonic–clonic seizures, and progressive myoclonic epilepsy in infants. It is a situation requiring fast and correct treatment, as the mortality rate is high. Various studies set the mortality rate as being from 10 to 30%, depending on treatment (Hauser 1990; Aicardi and Chevrie 1987).
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References
DeLorenzo, R., et al. (1996) A prospective population based epidemiologic study of statur epilepticus in Richmond Virginia. Neurology 46:1029–1035
Shinnar, S., et al. (2001) How long do new onset seizures in children last? ANN Neurology 49:659–664
DeLorenzo, R., et al. (1999) Comparison of status epilepticus with prolonged seizure episodes lasting from 10–29 minutes. Epilepsia 40:164–169
Hauser, W., et al. (1990) Seizure recurrence after a first unprovoked seizure: an extended follow up. Neurology 40:1163–1164
Hauser, W. (1990) Status epilepticus: epidemiologic considerations Neurology 40:suppl:9–13
Waterhouse, E., et al. (1998) Synergistic effect of status epilepticus and ischemic brain injury on mortality Epil Res 29:175–183
Sagduyu, A., Tarlaci, S., and Sirin, H. (1998) Generalized tonic clonic status epilepticus: causes, treatment, complications and predictors of case fatality. J. Neurol. 245:640–646
Towne, A., et al. (1994) Determinants of mortality in status epilepticus. Epilepsia 35:27–34
Mayer, S., et al. (2002) Refractory status epilepticus Arch Neurology 59:205–210
Krumholz, A., et al. (1995) Complex partial status epilepticus accompanied by serious morbidity and mortality. Neurology 45:1499–1504
DeLorenzo, R., et al. (1998) Persistent nonconvulsive status epilepticus after the control of convulsive status epilepticus Epilepsia 39:833–840
Nei, M., et al. (1999) The EEG and prognosis in status epilepticus. Epilepsia 40:157–163
Lawn, N., and Wijdicks, E. (2002) Status epilepticus: a critical review of management options. Can J Neurol Sci 29:206–215
Meldrum, B., and Brierly, J. (1978) Prolonged epileptic seizures in primates: ischemic cell change and its relation to ictal physiological events. Arch Neurol. 28:10–17
Rossetti, A., and Bromfield, E. (2005) Levetiracetam in the treatment of status epilepticus in adults: a study of 13 episodes. European nerrology 54:34–38
Luders, H., et al. (1998) Semiological seizure classification. Epilepsia 39:1006–1013
Wilder-Smith, E., et al. (2005) The NORSE (new onset refractory status epilepticus) syndrome: defining a disease entity. Ann Acad Med Singapore 34:417–420
Thomas, P., Valton, L., and Genton, P., (2006) Absence and myoclonic status epilepticus precipitated by antiepileptic drugs in idiopathic generalized epilepsy. Brain 129:1281–1292
Bauer, J. (1996) Seizure inducing effects of antiepileptic drugs: a review. Acta Neurol. Scand 94:367–277
Lerman, P. (1986) Seizures induced or aggravated by anticonvulsants. Epilepsia 27:706–710
van Rooij, L., et al. (2007) Neurodevelopment outcome in term infants with status epilepticus detected with amplitude integrated electroencephalography. Pediatr 120:e354-e363
Miller, S., et al. (2002) Seizure associated brain injury in term newborns with perinatal asphyxia. Neurology 58:542–548
Younkin, D., et al. (1986) Cerebral metabolic effects of neonatal seizures measured with in vivo 31P NMR spectroscopy. Ann Neurol. 20:513–519
Baracskay, P., et al. (2009) Status epilepticus affects the gigantocellular network of the pontine reticular formation. BMC Neurosci. 10:133–144
Raisinghani, M., and Faingold, C. (2005) Pontine reticular formations are implicated in the neuronal network for genralized clonic seizures which is itensified by audiogenic kindling. Brain Res. 1064:90–97
Joo, E., Tae, W., and Hong, S. (2006) Regional effects of lamotrigine on cerebral glucose metabolism in idiopathic generalized epilepsy. Arch. Neurol. 63:1282–1286
Atillo, A., et al. (1983) Pathogenesis of brain lesions caused by experimental epilepsy. Acta Neuropathol. 59:37–49
Moruzzi, G., and Magoun, H. (1949) Brain stem reticular formation and activation of the EEG. Electroenceph. Clin Neurophys. 1:455–473
Parvizi, J., and Damasio, A. (2003) Neuroanatomical correlates of brainstem coma. 126:1524–1536
Bruno, R., et al. (1995) Pathophysiology of a central cause of post polio fatigue. Ann NY Acad Sci 753:257–275
Scott, R. (2010) Adverse outcomes following convulsive status epilepticus in children: relationship with hippocampal injury. Epilepsia 51:178–181
Scott, R., et al. (2002) Magnetic resonance imaging findings within 5 days of status epilepticus in childhood. Brain 125:1951–1959
Naylor, D. (2010) Glutamate and GABA in the balance: Convergent pathways sustain seizures during status epilepticus. Epilepsia 51:106–109
Naylor, D., Liu, H., and Wsterlain, C. (2005) Trafficking of GABAa receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus. J. Neurosci. 25:7724–7733
Suchomelova, L., et al. (2006) Treatment of experimental status epilepticus in immature rats: dissociation between anticonvulsant and antiepileptic effects. Pediatr Res 59:237–243
White, A., et al. (2010) EEG spike activity precedes epilepsy after kainate induced status epilepticus. Epilepsia 51:371–383
Shinnar, S., et al. (2001) Language regression in childhood Pediatric Neurology 24:183–189
Hesdorffer, D., et al. (1998) Risk of unprovoked seizure after acute symptomatic seizure: effect of status epilepticus. Ann Neurol. 44:908–912
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McCandless, D.W. (2012). Status Epilepticus. In: Epilepsy. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0361-6_23
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DOI: https://doi.org/10.1007/978-1-4614-0361-6_23
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