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Nocturnal Epilepsy Animal Models

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Abstract

Animal models of nocturnal frontal lobe epilepsy are not as easy to produce as other animal models of human epilepsy. This is in part due to the main feature of these seizures – they occur during sleep, so are not readily observable. They are of course, complex partial seizures, so have many features of those originating from temporal lobe structures. One reason the classification of “temporal lobe epilepsy” has fallen from widespread use is that these seizures can originate from foci adjacent to, but removed from the temporal cortex.

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References

  • Lee, K., et al. (1997) A genetic animal model of human neocortical heterotopia associated with seizures. J. Neurosci. 17:6236–6242

    PubMed  CAS  Google Scholar 

  • Caviness, V., and Rakic, P. (1978) Mechanisms of cortical development: a view from mutations in mice. Ann. Rev. Neurosci. 1:297–326

    Article  PubMed  Google Scholar 

  • Meencke, H., and Veith, H. (1992) Migration disturbances in epilepsy. Epil. Rs. 9:31–40

    CAS  Google Scholar 

  • Figl, A., et al. (1998) Two mutations linked to nocturnal frontal lobe epilepsy cause use dependent potentiation of the nicotinic Ach response. J. Physiol. 513:655–670

    Article  PubMed  CAS  Google Scholar 

  • Morita, T., et al. (2002) Cliniconeuropathologic findings of familial frontal lobe epilepsy in Shetland sheepdogs. Can. J. Vet Res. 66:35–41

    PubMed  CAS  Google Scholar 

  • Silva-Barrat, C., et al. (1986) Multiunitary activity analysis of cortical and subcortical structures in paroxysmal discharges and grand mal seizures in photosensitive baboons. Electroenceph. Clin. Neurophys. 64:455–468

    Article  CAS  Google Scholar 

  • Ishida, N., et al. (1993) Epileptic seizure of EL mouse initiates at the parietal cortex. Brain Res. 608:52–57

    Article  PubMed  CAS  Google Scholar 

  • Dobelis, P., et al. (2003) GABAergic systems modulate nicotinic receptor mediated seizures in mice. J PET 306:1150–1166

    Google Scholar 

  • Fonck, C., et al. (2003) Increased sensitivity to agonist induced seizures, Straub tail, and hippocampal theta rhythm in knock in mice carrying hypersensitive alpha4 nicotinic receptors. J. Neurosci. 23:2582–2590

    PubMed  CAS  Google Scholar 

  • Zucconi, M., and Ferini-Strambi, L. (2000) NREM parasomnias: arousal disorders and differentiation from nocturnal frontal lobe epilepsy. Clin Neurophysiol. 111:S129-S135

    Article  PubMed  Google Scholar 

  • Klaassen, A., et al. (2006) Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy. PNAS 103:19152–19157

    Article  PubMed  CAS  Google Scholar 

  • Teper, Y., et al. (2007) Nicotine induced dystonic arousal complex in a mouse line harboring a human autosomal dominant nocturnal frontal lobe epilepsy mutation. J. Neurosci. 27:10128–10142

    Article  PubMed  CAS  Google Scholar 

  • Bertrand, D., et al. (2005) The CHRNAB2 mutation 1312M is associated with epilepsy and distinct memory deficits Neurobiol. Dis. 20:799–804

    CAS  Google Scholar 

  • Brodtkorb, E., and Picard, F. (2006) Tobacco habits modulate autosomal dominate nocturnal frontal lobe epilepsy. Epil. Behav. 9:515–520

    Article  Google Scholar 

  • Du, W., et al. (2005) Calcium sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder. Nat. Genet. 37:733–738

    Article  PubMed  CAS  Google Scholar 

  • Guerrini, R., et al. (2002) Early onset absence epilepsy and paroxysmal dyskinesia. Epilepsia 43:344–352

    Article  Google Scholar 

  • Yu, F., et al. (2006) Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. Nat. Neurosci. 9:1142–1149

    Article  PubMed  CAS  Google Scholar 

  • Kedmi, M., and Orr-Urtreger, A. (2007) Expression changes in mouse brains following nicotine induced seizures: the modulation of transcription factor networks. Physiol. Genom. 30:242–252

    Article  CAS  Google Scholar 

  • Boschert, U., et al. (1998) Regulated expression of dual specificity protein phosphatases in rat brain. Neurorep. 9:4081–4086

    Article  CAS  Google Scholar 

  • Kodama, M., Russell, D., and Duman, R. (2005) Electroconvulsive seizures increase the expression of MAP kinase phosphatases in limbic regions of rar brain. Neuropsychopharm. 30:360–371

    Article  CAS  Google Scholar 

  • Reppert, S., and Eeaver, D. (2002) Coordination of circadian timing in mammals. Nature 418:935–941

    Article  PubMed  CAS  Google Scholar 

  • Zhu, G., et al. (2008) Rats harboring S284L CHRNA4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype. J. Neurosci. 28:12465–12476

    Article  PubMed  CAS  Google Scholar 

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McCandless, D.W. (2012). Nocturnal Epilepsy Animal Models. In: Epilepsy. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0361-6_16

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