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RNA Interactions

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RNA Infrastructure and Networks

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 722))

Abstract

Noncoding RNAs form an indispensible component of the cellular information processing networks, a role that crucially depends on the specificity of their interactions among each other as well as with DNA and protein. Patterns of intramolecular and intermolecular base pairs govern most RNA interactions. Specific base pairs dominate the structure formation of nucleic acids. Only little details distinguish intramolecular secondary structures from those cofolding molecules. RNA-protein interactions, on the other hand, are strongly dependent on the RNA structure as well since the sequence content of helical regions is largely unreadable, so that sequence specificity is mostly restricted to unpaired loop regions. Conservation of both sequence and structure thus this can give indications of the functioning of the diversity of ncRNAs.

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Authors and Affiliations

  1. Bioinformatics Group, Department of Computer Science and Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany

    Manja Marz & Peter F. Stadler

  2. RNA-Bioinformatics Group, Institut für Pharmazeutische Chemie, Philipps- Universität Marburg, Marburg, Germany

    Manja Marz

  3. Institute for Theoretical Chemistry, University of Vienna, Wien, Austria

    Peter F. Stadler

  4. Fraunhofer Institute for Cell Therapy und Immunology, Leipzig, Germany

    Peter F. Stadler

  5. Santa Fe Institute, Santa Fe, New Mexico, USA

    Peter F. Stadler

Authors
  1. Manja Marz
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  2. Peter F. Stadler
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Editors and Affiliations

  1. Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand

    Lesley J. Collins

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© 2011 Landes Bioscience and Springer Science+Business Media, LLC

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Marz, M., Stadler, P.F. (2011). RNA Interactions. In: Collins, L.J. (eds) RNA Infrastructure and Networks. Advances in Experimental Medicine and Biology, vol 722. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0332-6_2

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