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Cancer Stem Cells, Models of Study and Implications of Therapy Resistance Mechanisms

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Human Cell Transformation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 720))

Abstract

There is now compelling evidence for tumour initiating or cancer stem cells (CSCs) in human cancers. The current evidence of this CSC hypothesis, the CSC phenotype and methods of identification, culture and in vitro modelling will be presented, with an emphasis on prostate cancer. Inherent in the CSC hypothesis is their dual role, as a tumour-initiating cell, and as a source of treatment-resistant cells; the mechanisms behind therapeutic resistance will be discussed. Such resistance is a consequence of the unique CSC phenotype, which differs from the differentiated progeny, which make up the bulk of a tumour. It seems that to target the whole tumour, employing traditional therapies to target bulk populations alongside targeted CSC-specific drugs, provides the best hope of lasting treatment or even cure.

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Acknowledgements

This work was funded by Yorkshire Cancer Research.

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Authors and Affiliations

  1. Department of Biology, YCR Cancer Research Unit, University of York, Heslington, North Yorkshire, YO10 5DD, UK

    Fiona M. Frame

  2. YCR Cancer Research Unit, Department of Biology, University of York, Heslington, North Yorkshire, UK

    Norman J. Maitland

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Correspondence to Fiona M. Frame .

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  1. Uniformed Services, Department of Surgery, University of the Health Sciences, South Glen Road 11455, Bethesda, 20854, Maryland, USA

    Johng S. Rhim

  2. , Department of Medicine, McGill University Health Centre, Pine Ave 687, Montreal, Québec, Canada

    Richard Kremer

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Frame, F.M., Maitland, N.J. (2011). Cancer Stem Cells, Models of Study and Implications of Therapy Resistance Mechanisms. In: Rhim, J., Kremer, R. (eds) Human Cell Transformation. Advances in Experimental Medicine and Biology, vol 720. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0254-1_9

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