Abstract
Traumatic brain injuries (TBI) are common, and often lead to permanent cognitive impairment. Despite the prevalence and severity of TBI, the condition remains poorly understood. Computer simulations of injury mechanics offer enormous potential for the study of TBI; however, computer models require accurate descriptions of tissue constitutive behavior and brain-skull boundary conditions. Magnetic resonance elastography (MRE) is a non-invasive imaging modality that provides quantitative spatial maps of tissue stiffness in vivo. MRE is performed by inducing micron-amplitude propagating shear waves into tissue and imaging the resulting motion with a specialized “motion-sensitive” MRI pulse sequence. Invoking a restricted form of Navier’s equation these data can be inverted to estimate material stiffness. As such, clinical interest in MRE has largely been driven by the direct empirical relationship between tissue stiffness and health. However, the so-called “raw” MRE data themselves (3-D displacement measurements) and calculated strains can elucidate loading paths, anatomic boundaries and the dynamic response of the intact human head. In this study, we use the MRE imaging technique to measure in vivo displacement fields of brain motion as the cranium is exposed to acoustic frequency pressure excitation (45, 60, 80 Hz) and calculate the resulting shear-strain fields (2-D).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Faul, M., et al., Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations and Deaths 2002–2006, C.f.D.C.a.P. U.S. Department of Health and Human Services, National Center of Injury Prevention and Control, 2010: Atlanta, GA.
Holbourn, A.H.S., Mechanics of Head Injuries. The Lancet, 1943. 242(6267): p. 438–441.
Smith, D.H., D.F. Meaney, and W.H. Shull, Diffuse axonal injury in head trauma. The Journal of head trauma rehabilitation, 2003. 18(4): p. 307–16.
McCracken, P.J., et al. Transient MR Elastography: Modeling Traumatic Brain Injury. in MICCAI. 2004.
Green, M.A., L.E. Bilston, and R. Sinkus, In vivobrain viscoelastic properties measured by magnetic resonance elastography. NMR in Biomedicine, 2008. 21(7): p. 755–764.
Sack, I., et al., Non-invasive measurement of brain viscoelasticity using magnetic resonance elastography. NMR in Biomedicine, 2008. 21(3): p. 265–271.
Meaney, D.F., et al., Biomechanical Analysis of Experimental Diffuse Axonal Injury. Journal of Neurotrauma, 1995. 12(4): p. 689–694.
Muthupillai, R., et al., Magnetic resonance elastography by direct visualization of propagating acoustic strain waves. Science (New York, N Y ), 1995. 269(5232): p. 1854–7.
McCracken, P.J., A. Manduca, and R.L. Ehman, MR Elastography for Studying the Biomechanics of Traumatic Brain Injury, in International Society for Magnetic Resonance in Medicine. 2003. p. 799.
Muthupillai, R., et al., Magnetic Resonance Imaging of Transverse Acoustic Strain Waves. Magnetic Resonance in Medicine, 1996. 36(2).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media, LLC
About this paper
Cite this paper
Clayton, E.H., Bayly, P.V. (2011). Brain Response to Extracranial Pressure Excitation Imaged in vivo by MR Elastography. In: Proulx, T. (eds) Mechanics of Biological Systems and Materials, Volume 2. Conference Proceedings of the Society for Experimental Mechanics Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0219-0_7
Download citation
DOI: https://doi.org/10.1007/978-1-4614-0219-0_7
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-0218-3
Online ISBN: 978-1-4614-0219-0
eBook Packages: EngineeringEngineering (R0)