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Diagnosis of Age-Related Macular Degeneration

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Age-related Macular Degeneration Diagnosis and Treatment

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Abstract

Classifying AMD helps physicians counsel patients, make treatment decisions, and standardize clinical trials. The presentation of AMD can vary widely and thus the differential diagnosis is large. Medical and ocular history, ophthalmoscopy, and ancillary testing can be used in combination to narrow the differential diagnosis. When the response to standard therapy is not typical, the diagnosis of AMD may need to be revisited.

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References

  1. Kahn HA, Leibowitz HM, Ganley JP, Kini MM, Colton T, Nickerson RS, et al. The Framingham Eye Study II. Association of ophthalmic pathology with single variables previously measured in the Framingham Heart Study. Am J Epidemiol. 1977;106(1):33–41.

    PubMed  CAS  Google Scholar 

  2. Gass JDM. Pathogenesis of disciform detachment of the neuroepithelium. II. Idiopathic central serous choroidopathy. Am J Ophthalmol. 1960;63:587–615.

    Google Scholar 

  3. Russell SR, Mullins RF, et al. Location, substructure, and composition of basal laminar drusen compared with drusen associated with age-related macular degeneration. Am J Ophthalmol. 2000;129:205–14.

    Article  PubMed  CAS  Google Scholar 

  4. Abdelsalam A, Del Priore L, Zarbin MA. Drusen in age-related macular degeneration: pathogenesis, ­natural course, and laser photocoagulation-induced regression. Surv Ophthalmol. 1999;44(1):1–29. Review.

    Article  PubMed  CAS  Google Scholar 

  5. Gass JD. Drusen and disciform macular detachment and degeneration. Arch Ophthalmol. 1973;90(3):206–17.

    PubMed  CAS  Google Scholar 

  6. Green WR, McDonnell PJ, Yeo JH. Pathologic features of senile macular degeneration. Ophthalmology. 1985;92(5):615–27.

    PubMed  CAS  Google Scholar 

  7. Sarks SH. Council lecture. Drusen and their relationship to senile macular degeneration. Aust J Ophthalmol. 1980;8(2):117–30.

    Article  PubMed  CAS  Google Scholar 

  8. Holz FG, Wolfensberger TJ, Piguet B, Gross-Jendroska M, Wells JA, Minassian DC, et al. Bilateral macular drusen in age-related macular degeneration. Prognosis and risk factors. Ophthalmology. 1994;101(9):1522–8.

    PubMed  CAS  Google Scholar 

  9. Spraul CW, Grossniklaus HE. Characteristics of Drusen and Bruch’s membrane in postmortem eyes with age-related macular degeneration. Arch Ophthalmol. 1997;115(2):267–73.

    PubMed  CAS  Google Scholar 

  10. Gass JD. Stereoscopic atlas of macular disease: diagnosis and treatment. 4th ed. St. Louis: Mosby; 1997.

    Google Scholar 

  11. Lim JI. Age-related macular degeneration. New York: Marcel Dekkar, Inc.; 2002.

    Book  Google Scholar 

  12. Klein R, Klein BE, Jensen SC, Meuer SM. The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology. 1997;104(1):7–21.

    PubMed  CAS  Google Scholar 

  13. Klein ML, Mauldin WM, Stoumbos VD. Heredity and age-related macular degeneration. Observations in monozygotic twins. Arch Ophthalmol. 1994;112(7):932–7.

    PubMed  CAS  Google Scholar 

  14. Macular Photocoagulation Study Group. Risk factors for choroidal neovascularization in the second eye of patients with juxtafoveal or subfoveal choroidal neovascularization secondary to age-related macular degeneration. Arch Ophthalmol. 1997;115(6):741–7.

    Google Scholar 

  15. Ferris 3rd FL, Fine SL, Hyman L. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch Ophthalmol. 1984;102(11):1640–2.

    PubMed  Google Scholar 

  16. Sunness JS, Gonzalez-Baron J, Applegate CA, Bressler NM, Tian Y, Hawkins B, et al. Enlargement of atrophy and visual acuity loss in the geographic atrophy form of age-related macular degeneration. Ophthalmology. 1999;106(9):1768–79.

    Article  PubMed  CAS  Google Scholar 

  17. Macular Photocoagulation Study Group. Five-year follow-up of fellow eyes of patients with age-related macular degeneration and unilateral extrafoveal choroidal neovascularization. Arch Ophthalmol. 1993;111(9):1189–99.

    Google Scholar 

  18. Bressler NM, Frost LA, Bressler SB, Murphy RP, Fine SL. Natural course of poorly defined choroidal neovascularization associated with macular degeneration. Arch Ophthalmol. 1988;106(11):1537–42.

    PubMed  CAS  Google Scholar 

  19. Bird AC, Bressler NM, Bressler SB, et al. An international classification and grading system for age-­related maculopathy and age-related macular degeneration. Surv Ophthalmol. 1995;39:367–74.

    Article  PubMed  CAS  Google Scholar 

  20. Klein R, Klein BE, Linton KL. Prevalence of age-­related maculopathy. The Beaver Dam Eye Study. Ophthalmology. 1992;99(6):933–43.

    PubMed  CAS  Google Scholar 

  21. The Age-Related Eye Disease Study Research Group. The Age-Related Eye Disease Study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: the Age-Related Eye Disease Study Report Number 6. Am J Ophthalmol. 2001;132:668–81.

    Article  Google Scholar 

  22. Jager RD, Mieler WF, Mille JW. Age-related macular degeneration. N Engl J Med. 2008;358:2606–17.

    Article  PubMed  CAS  Google Scholar 

  23. Green WR, Gass JDM. Senile disciform degeneration of the macula. Arch Ophthalmol. 1971;100:487–94.

    Google Scholar 

  24. Green WR, Enger C. Age-related macular degeneration histopathologic studies: the 1992 Lorenz E. Zimmerman lecture. Ophthalmology. 1993;100:1519–35.

    PubMed  CAS  Google Scholar 

  25. Yannuzzi LA, Negrao S, Iida T, et al. Retinal angiomatous proliferation in age-related macular degeneration. Retina. 2001;21:416–34.

    Article  PubMed  CAS  Google Scholar 

  26. Borrillo JL, Sivalingam A, Martidis A, et al. Surgical ablation of retinal angiomatous proliferation. Arch Ophthalmol. 2003;121:558–61.

    Article  PubMed  Google Scholar 

  27. Fernandes LH, Freund KB, Yannuzzi LA, et al. The nature of focal areas of hyperfluorescence or hot spots imaged with indocyanine green angiography. Retina. 2002;22:557–68.

    Article  PubMed  Google Scholar 

  28. Stern RM, Zakov N, Zegarra H, et al. Multiple recurrent serous sanguineous retinal pigment epithelial detachments in black women. Am J Ophthalmol. 1985;100:560–9.

    PubMed  CAS  Google Scholar 

  29. Yannuzzi LA, Sorenson J, Spaide RF, et al. Idiopathic polypoidal choroidal vasculopathy. Retina. 1990;10:1–8.

    Article  PubMed  CAS  Google Scholar 

  30. Laude A, Cackett PD, Vithana EN, Yeo IY, Wong D, Koh AH, et al. Polypoidal choroidal vasculopathy and neovascular age-related macular degeneration: same or different disease? Prog Retin Eye Res. 2010;29(1):19–29. 2009 Oct 23.

    Article  PubMed  Google Scholar 

  31. Yannuzzi LA, Ciardella AP, Spaide RF, et al. The expanding clinical spectrum of idiopathic polypoidal vasculopathy. Arch Ophthalmol. 1997;115:478–85.

    PubMed  CAS  Google Scholar 

  32. Perkovich PT, Zakov N, Berlin LA, et al. An update on multiple recurrent serosanguineous retinal pigment epithelium detachments in black women. Retina. 1990;10:18–26.

    Article  PubMed  CAS  Google Scholar 

  33. Lafaut BA, Leyes AM, Snyders B, et al. Polypoidal choroidal vasculopathy in Caucasians. Graefes Arch Clin Exp Ophthalmol. 2000;238:752–9.

    Article  PubMed  CAS  Google Scholar 

  34. Uyama M, Wada M, Nagai Y, et al. Polypoidal choroidal vasculopathy: natural history. Am J Ophthalmol. 2002;133:639–48.

    Article  PubMed  Google Scholar 

  35. Japanese Study Group of Polypoidal Choroidal Vasculopathy. Criteria for diagnosis of polypoidal choroidal vasculopathy. Nippon Ganka Gakkai Zasshi. 2005;109:417–27.

    Google Scholar 

  36. Chan WM, Lam DS, Lai TY, Liu DT, Li KK, Yao Y, et al. Photodynamic therapy with verteporfin for symptomatic polypoidal choroidal vasculopathy: one-year results of a prospective case series. Ophthalmology. 2004;111:1576–84.

    Article  PubMed  Google Scholar 

  37. Sunness JS, Rubin GS, Applegate CA, Bressler NM, Marsh MJ, Hawkins BS, et al. Visual function abnormalities and prognosis in eyes with age-related geographic atrophy of the macula and good visual acuity. Ophthalmology. 1997;104(10):1677–91.

    PubMed  CAS  Google Scholar 

  38. Steinmetz RL, Haimovici R, Jubb C, Fitzke FW, Bird AC. Symptomatic abnormalities of dark adaptation in patients with age-related Bruch’s membrane change. Br J Ophthalmol. 1993;77(9):549–54.

    Article  PubMed  CAS  Google Scholar 

  39. Fine AM, Elman MJ, Ebert JE, Prestia PA, Starr JS, Fine SL. Earliest symptoms caused by neovascular membranes in the macula. Arch Ophthalmol. 1986;104(4):513–4.

    PubMed  CAS  Google Scholar 

  40. Bressler NM, Munoz B, Maguire MG, Vitale SE, Schein OD, Taylor HR, et al. Five-year incidence and disappearance of drusen and retinal pigment epithelial abnormalities. Waterman study. Arch Ophthalmol. 1995;113(3):301–8.

    PubMed  CAS  Google Scholar 

  41. Sunness JS, Gonzalez-Baron J, Bressler NM, Hawkins B, Applegate CA. The development of choroidal neovascularization in eyes with the geographic atrophy form of age-related macular degeneration. Ophthalmology. 1999;106(5):910–9.

    Article  PubMed  CAS  Google Scholar 

  42. Yannuzzi LA, Shakin JL, Fisher YL, et al. Peripheral retinal detachments and retinal pigment epithelial atrophic tracts secondary to central serous pigment epitheliopathy. Ophthalmology. 1984;91:1554–72.

    PubMed  CAS  Google Scholar 

  43. Spaide RF, Campeas L, Haas A, et al. Central serous chorioretinopathy in younger and older adults. Ophthalmology. 1996;103:2070–9; discussion 2079–80.

    PubMed  CAS  Google Scholar 

  44. Spaide RF, Hall LS, Haas A, et al. Indocyanine green videoangiography of older patients with central serous chorioretinopathy. Retina. 1996;16:203–13.

    Article  PubMed  CAS  Google Scholar 

  45. Marmor MF. New hypotheses on the pathogenesis and treatment of serous retinal detachment. Graefes Arch Clin Exp Ophthalmol. 1988;226:548–52.

    Article  PubMed  CAS  Google Scholar 

  46. Tittl MK, Spaide RF, Wong D, et al. Systemic findings associated with central serous chorioretinopathy. Am J Ophthalmol. 1999;128:63–8.

    Article  PubMed  CAS  Google Scholar 

  47. Yoshida T, Ohno-Matsui K, Ohtake Y, et al. Myopic choroidal neovascularization: a 10-year follow-up. Ophthalmology. 2003;110(7):1297–305.

    Article  PubMed  Google Scholar 

  48. Johnson DA, Yannuzzi LA, Shakin JL, et al. Lacquer cracks following laser treatment of choroidal neovascularization in pathologic myopia. Retina. 1998;18:118–24.

    Article  PubMed  CAS  Google Scholar 

  49. Armstrong JD, Meyer D, Xu S, et al. Long-term follow up of Stargardt’s disease and fundus flavimaculatus. Ophthalmology. 1998;105:448–58.

    Article  PubMed  CAS  Google Scholar 

  50. Weleber RG. Stargardt’s macular dystrophy. Arch Ophthalmol. 1994;112:752–4.

    PubMed  CAS  Google Scholar 

  51. Marmor MF, Byers B. Pattern dystrophy of the pigment epithelium. Am J Ophthalmol. 1977;84:32–44.

    PubMed  CAS  Google Scholar 

  52. Hsieh RC, Fine BS, Lyons JS. Patterned dystrophies of the retinal pigment epithelium. Arch Ophthalmol. 1977;95:429–35.

    PubMed  CAS  Google Scholar 

  53. Patrinely JR, Lewis RA, Font RL. Foveomacular vitelliform dystrophy, adult type. A clinicopathologic study including electron microscopic observations. Ophthalmology. 1985;92:1712–8.

    PubMed  CAS  Google Scholar 

  54. Jaffe GJ, Schatz H. Histopathologic features of adult-onset foveomacular pigment epithelial dystrophy. Arch Ophthalmol. 1988;106:958–60.

    PubMed  CAS  Google Scholar 

  55. Kim DD, Mieler WF, Wolf MD. Posterior segment changes in membranoproliferative glomerulonephritis. Am J Ophthalmol. 1992;114(5):593–9.

    PubMed  CAS  Google Scholar 

  56. Clarkson JG, Altman RD. Angioid streaks. Surv Ophthalmol. 1982;26:235–46.

    Article  PubMed  CAS  Google Scholar 

  57. Lim JI, Bressler NM, Marsh MJ, et al. Laser treatment of choroidal neovascularization in patients with angioid streaks. Am J Ophthalmol. 1993;116:414–23.

    PubMed  CAS  Google Scholar 

  58. Ho AC, Yannuzzi LA, Pisicano K, et al. The natural history of idiopathic subfoveal choroidal neovascularization. Ophthalmology. 1995;102:782–9.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Barnes Retina Institute, St. Louis, MO, USA

    Jonathan Jonisch M.D.

  2. Barnes Retina Institute, 1600 S. Brentwood Blvd, Ste. 800, St. Louis, MO, 63144, USA

    Gaurav Shah M.D.

Authors
  1. Jonathan Jonisch M.D.
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  2. Gaurav Shah M.D.
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Correspondence to Gaurav Shah M.D. .

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Editors and Affiliations

  1. Wills Eye Hospital, Walnut St. 840, Philadelphia, 19107, Pennsylvania, USA

    Allen C. Ho

  2. Wills Eye Hospital, Walnut St. 840, Philadelphia, 19107, Pennsylvania, USA

    Carl D. Regillo

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Jonisch, J., Shah, G. (2011). Diagnosis of Age-Related Macular Degeneration. In: Ho, A., Regillo, C. (eds) Age-related Macular Degeneration Diagnosis and Treatment. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0125-4_3

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  • DOI: https://doi.org/10.1007/978-1-4614-0125-4_3

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