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Advances in Understanding the Structure, Function, and Mechanism of the SCIN and Efb Families of Staphylococcal Immune Evasion Proteins

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Current Topics in Innate Immunity II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 946))

Abstract

Our understanding of both the nature and diversity of Staphylococcal immune evasion proteins has increased tremendously throughout the last several years. Among this group of molecules, members of the SCIN and Efb families of complement inhibitors have been the subject of particularly intense study. This work has demonstrated that both types of proteins exert their primary function by inhibiting C3 convertases, which lie at the heart of the complement-mediated immune response. Despite this similarity, however, significant differences in structure/function relationships and mechanisms of action exist between these bacterial proteins. Furthermore, divergent secondary effects on host immune responses have also been described for these two protein families. This chapter summarizes recent advances toward understanding the structure, function, and mechanism of the SCIN and Efb families, and suggests potential directions for the field over the coming years.

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Acknowledgements

The authors acknowledge support by US Public Health Service Grants AI071028 ( BVG), an American Heart Association Predoctoral Fellowship (BLG), and GM062134, AI030040, AI072106, AI068730 (JDL).

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Authors and Affiliations

  1. School of Biological Sciences, University of Missouri, 64110, Kansas City, MO, USA

    Brandon L. Garcia, Kasra X. Ramyar & Brian V. Geisbrecht

  2. School of Medicine, University of Pennsylvania, 19105, Philadelphia, PA, USA

    Daniel Ricklin & John D. Lambris

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  1. Brandon L. Garcia
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  2. Kasra X. Ramyar
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  3. Daniel Ricklin
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  4. John D. Lambris
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  5. Brian V. Geisbrecht
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Correspondence to Brian V. Geisbrecht .

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Editors and Affiliations

  1. Department Of Pathology Laboratory Of, Medicine, University Of Pennsylvania, Johnson Pavilion 410, Philadelphia, 19104, Pennsylvania, USA

    John D. Lambris

  2. Health Sciences Center, University of Louisville, Louisville, 40292, Kentucky, USA

    George Hajishengallis

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Garcia, B.L., Ramyar, K.X., Ricklin, D., Lambris, J., Geisbrecht, B.V. (2012). Advances in Understanding the Structure, Function, and Mechanism of the SCIN and Efb Families of Staphylococcal Immune Evasion Proteins. In: Lambris, J., Hajishengallis, G. (eds) Current Topics in Innate Immunity II. Advances in Experimental Medicine and Biology, vol 946. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0106-3_7

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