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Current Topics in Innate Immunity II pp 69–85Cite as

Pathogenic Microbes and Community Service Through Manipulation of Innate Immunity

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 946))

Abstract

The periodontal pathogen Porphyromonas gingivalis undermines major components of innate immunity, such as complement, Toll-like receptors (TLR), and their crosstalk pathways. At least in principle, these subversive activities could promote the adaptive fitness of the entire periodontal biofilm community. In this regard, the virulence factors responsible for complement and TLR exploitation (gingipain enzymes, atypical lipopolysaccharide molecules, and fimbriae) are released as components of readily diffusible membrane vesicles, which can thus become available to other biofilm organisms. This review summarizes important immune subversive tactics of P. gingivalis which might enable it to exert a supportive impact on the oral microbial community.

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Acknowledgments

The authors acknowledge support by US Public Health Service Grants DE015254, DE018292, DE017138, DE021580 (GH) and GM062134, AI030040, AI072106, AI068730 (JDL).

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Authors and Affiliations

  1. School of Dentistry, Oral Health and Systemic Disease, and School of Medicine, Microbiology and Immunology, University of Louisville, 501 South Preston Street, 40292, Louisville, KY, USA

    George Hajishengallis

  2. School of Dentistry, Oral Health and Systemic Disease, University of Louisville, 40292, Louisville, KY, USA

    Jennifer L. Krauss, Shuang Liang & Megan L. McIntosh

  3. Department of Pathology, Laboratory of Medicine, University of Pennsylvania, Johnson Pavilion 410, 19104, Philadelphia, PA, USA

    John D. Lambris

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  1. Department Of Pathology Laboratory Of, Medicine, University Of Pennsylvania, Johnson Pavilion 410, Philadelphia, 19104, Pennsylvania, USA

    John D. Lambris

  2. Health Sciences Center, University of Louisville, Louisville, 40292, Kentucky, USA

    George Hajishengallis

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Hajishengallis, G., Krauss, J.L., Liang, S., McIntosh, M.L., Lambris, J. (2012). Pathogenic Microbes and Community Service Through Manipulation of Innate Immunity. In: Lambris, J., Hajishengallis, G. (eds) Current Topics in Innate Immunity II. Advances in Experimental Medicine and Biology, vol 946. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0106-3_5

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