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Modeling Tumor Vasculature pp 213–233Cite as

Modeling Structural and Functional Adaptation of Tumor Vessel Networks During Antiangiogenic Therapy

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Abstract

In many physiological processes, endothelial cells respond to blood forces, re-organizing locally through a process of adaptation to alter blood flow. Some segments dilate, while others are pruned, and eventually, a stable configuration is reached. In contrast, tumor blood vessels are chronically immature and inefficient, unable to achieve optimum perfusion throughout the network. It is thought that the angiogenic growth factor vascular endothelial growth factor (VEGF) contributes to this inefficiency, and indeed, many anti-VEGF therapies can cause maturation or stabilization of tumor blood vessels through a process resembling adaptive remodeling. Unfortunately very little is known about how adaptive remodeling affects the distribution of blood flow and the transport of nutrients and drugs into the tumor. In general, remodeling depends on blood shear forces, transvascular pressure as well as growth factors such as VEGF. To provide an analytical framework for understanding this process, we have developed a mathematical model, supported by multiparameter imaging methodology, that incorporates the necessary elements for predicting the transport of nutrients and drugs throughout tumor vessels and tissue, as well as the adaptive remodeling of the blood vessel network.

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Authors and Affiliations

  1. Massachusetts General Hospital and Harvard Medical School, 149 13th Street, room 3409, Charlestown, MA, 02129, USA

    Lance L. Munn, Walid Kamoun, Michael Dupin & James Alex Tyrrell

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  1. Lance L. Munn
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  2. Walid Kamoun
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  3. Michael Dupin
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  4. James Alex Tyrrell
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Correspondence to Lance L. Munn .

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  1. Dept. Mathematics, University of Michigan, 530 Church Street, Ann Arbor, Michigan, 48109, USA

    Trachette L. L. Jackson

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Munn, L.L., Kamoun, W., Dupin, M., Tyrrell, J.A. (2012). Modeling Structural and Functional Adaptation of Tumor Vessel Networks During Antiangiogenic Therapy. In: Jackson, T.L. (eds) Modeling Tumor Vasculature. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0052-3_9

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