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Thyroid Gland

  • Linda M. Ernst
Chapter

Abstract

By the beginning of the fetal period, the thyroid gland has attained its proper anatomical position anterior to the laryngeal and tracheal structures and has acquired its bilobed shaped with the two lobes connected by a narrow isthmus. However, the histological appearance of the fetal thyroid gland is quite different from the mature adult thyroid gland, especially early in the second trimester of gestation. Therefore, the tissues of the fetal thyroid gland may be overlooked or mischaracterized. This chapter reviews the histological changes in the thyroid gland over the fetal period and discusses the two main functional components of the thyroid gland: the thyroid follicles that produce colloid and the parafollicular C cells that produce calcitonin.

Keywords

Thyroid Gland Prussian Blue Fetal Period Thyroid Follicle Thyroid Follicular Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Schoenwolf GC, Larsen WJ: Larsen’s Human Embryology, edn 4. Philadelphia, PA: Elsevier/Churchill Livingstone; 2009.Google Scholar
  2. 2.
    Sadler TW, Langman J: Langman’s Medical Embryology, edn 11. Philadelphia, PA: Wolters Kluwer Lippincott Williams & Wilkins; 2010.Google Scholar
  3. 3.
    Zoeller RT, Crofton KM: Thyroid hormone action in fetal brain development and potential for disruption by environmental chemicals. Neurotoxicology 2000, 21:935–945.PubMedGoogle Scholar
  4. 4.
    Park SM, Chatterjee VK: Genetics of congenital hypothyroidism. J Med Genet 2005, 42:379–89.PubMedCrossRefGoogle Scholar
  5. 5.
    Contempre B, Jauniaux E, Calvo R, et al.: Detection of thyroid hormones in human embryonic cavities during the first trimester of pregnancy. J Clin Endocrinol Metab 1993, 77:1719–1722.PubMedCrossRefGoogle Scholar
  6. 6.
    De Felice M, Di Lauro R: Thyroid development and its disorders: genetics and molecular mechanisms. Endocr Rev 2004, 25:722–746.PubMedCrossRefGoogle Scholar
  7. 7.
    Carcangiu M: Thyroid. In Histology for Pathologists, edited by Mills SE. Philadelphia, PA: Lippincott Williams & Wilkins; 2007:1137–1138.Google Scholar
  8. 8.
    Fisher D, Greuters A: Disorders of the thyroid in the newborn and infant. In Pediatric Endocrinology, 3rd edn. Philadelphia, PA: Saunders/Elsevier; 2008:200.Google Scholar
  9. 9.
    Shepard TH, Andersen H, Andersen HJ: Histochemical studies of the human fetal thyroid during the first half of fetal life. Anat Rec 1964, 149:363–379.PubMedCrossRefGoogle Scholar
  10. 10.
    Hazard JB: The C cells (parafollicular cells) of the thyroid gland and medullary thyroid carcinoma. A review. Am J Pathol 1977, 88:213–250.PubMedGoogle Scholar
  11. 11.
    Carpenter GR, Emery JL: Inclusions in the human thyroid. J Anat 1976, 122:77–89.PubMedGoogle Scholar
  12. 12.
    Sagreiya K, Emery JL: Perinatal thyroid discharge. A histological study of 1225 infant thyroids. Arch Dis Child 1970, 45:746–754.PubMedCrossRefGoogle Scholar
  13. 13.
    Cameselle-Teijeiro J, Preto A, Soares P, Sobrinho-Simoes M: A stem cell role for thyroid solid cell nests. Hum Pathol 2005, 36:590–591.PubMedCrossRefGoogle Scholar
  14. 14.
    Burstein DE, Unger P, Nagi C, Wang BY: Thinking “out of the nest”—a reply to “a stem-cell role for thyroid solid cell nests [letter]”. Hum Pathol 2005, 36:591–592.PubMedCrossRefGoogle Scholar
  15. 15.
    Burstein DE, Nagi C, Wang BY, Unger P: Immunohistochemical detection of p53 homolog p63 in solid cell nests, papillary thyroid carcinoma, and hashimoto’s thyroiditis: a stem cell hypothesis of papillary carcinoma oncogenesis. Hum Pathol 2004, 35:465–473.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Linda M. Ernst
    • 1
  1. 1.Department of PathologyNorthwestern University Feinberg School of MedicineChicagoUSA

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