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The Interrelationships among Folate, Vitamin B12, and Methionine Metabolism

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Advances in Nutritional Research

Part of the book series: Advances in Nutritional Research ((ANUR))

Abstract

The interrelationship between vitamin B12 and folate metabolism in man is best illustrated by the hematologically indistinguishable, macrocytic megaloblastic anemia resulting from a deficiency of either vitamin. Large pharmacological doses of either vitamin will elicit a hematological response in patients suffering from a deficiency of either or even both vitamins (Marshall and Jandl, 1960; Zalusky et al., 1962). For instance, large doses of folate cause a temporary or partial hematological remission in pernicious anemia patients but fail to correct the neurological lesions that arise from prolonged vitamin B12 deprivation.

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Authors and Affiliations

  1. Department of Biochemistry, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland, 21205, USA

    Barry Shane

  2. Department of Nutritional Sciences, University of California, Berkeley, California, 94720, USA

    E. L. Robert Stokstad

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  1. Barry Shane
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  1. University of Guelph, Guelph, Ontario, Canada

    Harold H. Draper

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Shane, B., Stokstad, E.L.R. (1983). The Interrelationships among Folate, Vitamin B12, and Methionine Metabolism. In: Draper, H.H. (eds) Advances in Nutritional Research. Advances in Nutritional Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-9937-7_7

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