Nutrition of the Cancer Patient

  • J. W. T. Dickerson
Part of the Advances in Nutritional Research book series (ANUR)

Abstract

Cancerous tissues, like parasites, derive the material necessary for their growth from the host. Like parasites, cancers do not contribute to the well-being of the host, rather the reverse, for animal experiments have shown that tumors grow at the expense of host tissues, independently of the host’s diet (White, 1945). It is clear, therefore, that tumors can cause catabolism of host tissues and if this occurs in the face of an inadequate dietary intake, the host will become malnourished and a variety of metabolic changes will occur.

Keywords

Magnesium Oncol Sarcoma Diarrhea Methotrexate 

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References

  1. Aksoy, M., Basu, T. K., Brient, J., and Dickerson, J. W. T. 1980, Thiamin status of patients treated with drug combinations containing 5-fluorouracil, Eur. J. Cancer 16: 1041.Google Scholar
  2. Atukorala, S., Basu, T. K., Dickerson, Donald, D., and Sakula, A. 1979, Vitamin A, zinc and lung cancer, Br. J. Cancer 40: 927.Google Scholar
  3. Atukorala, S., Dickerson, J. W. T., Basu, T. K., and McElwain, T., 1982, Longitudinal studies of nutritional status in patients having chemotherapy for testicular teratomas, in preparation.Google Scholar
  4. Basu, T. K., Patel, D. R., and Williams, D. C., 1974a, A simplified micro-assay of transketolase in human blood, Int. J. Vitam. Nutr. Res. 44: 319.Google Scholar
  5. Basu, T. K., Raven, R. W., Dickerson, J. W. T., and Williams, D. C., 1974b, Leucocyte ascorbic acid and urinary hydroxyproline levels in patients bearing breast tumour with skeletal metastases, Eur. J. Cancer 10: 507.Google Scholar
  6. Basu, T. K., Donaldson, D., Jenner, M., Williams, D. C., and Sakula, A. 1976, Plasma vitamin A in patients with bronchial carcinoma, Br. J. Cancer 33: 119.Google Scholar
  7. Bernstein, I. L., and Sigmundi, R. A., 1980, Tumor anorexia: A learned food aversion? Science 209: 416.Google Scholar
  8. Bodansky, O., Wroblewski, F., and Markardt, O., 1952, Concentration of ascorbic acid in plasma and white blood cells of patients with cancer and non-cancerous chronic disease, Cancer 5: 678.Google Scholar
  9. Booth, C. C., Maclntyre, I., and Mollin, D. L., 1964, Nutritional problems associated with extensive lesions of the distal small intestine in man, Q. J. Med. 33: 401.Google Scholar
  10. Bozzetti, F., Pagnoni, A. M., and Del Vecchio, M., 1980, Excessive calorie expenditure as a cause of malnutrition in patients with cancer, Surg. Gynecol. Obstet. 150: 229.Google Scholar
  11. Brennan, M. F., 1979, Metabolic response to surgery in the cancer patient, Cancer 43: 2053.Google Scholar
  12. Brennan, M. F., 1981, Total parenteral nutrition in the management of the cancer patient, Acta Chir. Scand. Suppl. 507: 428.Google Scholar
  13. Brewin, T. B., 1980, Can a tumor cause the same appetite perversion or taste change as pregnancy? Lancet 2: 907.Google Scholar
  14. Brookes, G. B., and Clifford, P., 1981, Nutritional status and general immune competence in patients with head and neck cancer, J. R. Soc. Med. 74: 132.Google Scholar
  15. Brown, R. R., 1972, Normal and pathological conditions which may alter the human requirements for vitamin B6, J. Agr. Food Chem. 20: 498.Google Scholar
  16. Brunt, T. W., Sircus, W., and Maclean, N., 1969, Neoplasia and coeliac syndrome in adults, Lancet 1: 180.Google Scholar
  17. Calman, K. C., McAllister, R. A., and Soukop, M., 1977, Correction of changes in liver metabolites of mice following curative tumor resection, Br. J. Cancer 36: 405.Google Scholar
  18. Cameron, E., and Pauling, L., 1976, Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer, Proc. Natl. Acad. Sci. USA 73: 3685.Google Scholar
  19. Cameron, E., and Pauling, L., 1978, Supplemental ascorbate in the supportive treatment of cancer: Re-evaluation of prolongation of survival times in terminal human cancer, Proc. Natl. Acad. Sci. USA 75: 4538.Google Scholar
  20. Carson, J. A. S., and Gormican, A., 1977, Test acquity and food attitudes of selected patients with cancer, J. Am. Diet. Assoc. 70: 361.Google Scholar
  21. Chopra, I. J., and Smith, S. R., 1975, Circulating thyroid hormones and thyrotropin in adult patients with protein-caloric malnutrition, J. Clin. Endocrinol. Metab. 40: 221.Google Scholar
  22. Collery, P., 1976, Etude clinique et pathogénique des thromboses veineuses et embolies pulmonaires au cours des cancers bronchiques et pulmonaires. Déductions therapeutiques, Thèse Med. Reims No. 29.Google Scholar
  23. Collery, P., Coudoux, P., and Geoffroy, H., 1979, Role of magnesium in venous thrombogenesis in cancer: Changes in magnesium levels in neoplastic diseases, in: Nutrition and Cancer ( J. van Eys, M. S. Seelig, and B. L. Nichols, eds.), pp. 219–231, SP Medical and Scientific Books, New York.Google Scholar
  24. Copeland, E. M., Macfadyen, B. V., Jr., Lanzotti, V., and Dudrick, S. J., 1975, Intravenous hyperalimentation as an adjunct to cancer chemotherapy, Am. J. Surg. 129: 167.Google Scholar
  25. Copeland, E. M., Daly, J. M., and Dudrick, S. J., 1977, Nutrition as an adjunct to cancer treatment in the adult, Cancer Res. 37: 2451.Google Scholar
  26. Costa, G., and Holland, J. F., 1962, Effects of Krebs-2 carcinoma on the lipid metabolism of male Swiss mice, Cancer Res. 22: 1081.Google Scholar
  27. Costa, G., and Weathers, A. P., 1964, Cancer and the nutrition of the host, J. Am. Diet. Assoc. 44: 15.Google Scholar
  28. Costa, G., Lyles, K., and Ullrich, L., 1976, Effects of human and experimental cancer on the conversion of 14C tripalmitin to 14CO2, Cancer 38: 1259.Google Scholar
  29. Creagan, E. T., Moertal, C. G., O’Fallon, J. R., Schultz, A. J., O’Connell, M. J., Rubin, J., and Frytak, S., 1979, Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer, N. Engl. J. Med. 301: 687.Google Scholar
  30. Crisp, A. H., 1978, Disturbances of neurotransmitter metabolism in anorexia nervosa, Proc. Nutr. Soc. 37: 201.Google Scholar
  31. Cuschieri, A., 1973, Urinary hydroxyproline excretion in early and advanced breast cancer-a sequential study, Br. J. Surg. 60: 800.Google Scholar
  32. De Luca, L., Maestri, N., Bonanni, F., and Nelson, D., 1972, Maintenance of epithelial cell differentiation: The mode of action of vitamin A, Cancer 30: 1326.Google Scholar
  33. DeWys, W. D., 1977, Changes in taste sensation in cancer patients: correlation with caloric intake, in: The Chemical Senses and Nutrition ( M. R. Kare and O. Mailer, eds.), pp. 381–389, Academic Press, London.Google Scholar
  34. DeWys, W. D., 1978, Changes in taste sensation and feeding behaviour in cancer patients, J. Human Nutr. 32: 447.Google Scholar
  35. DeWys, W. D., and Walters, K., 1975, Abnormalities of taste sensation in cancer patients, Cancer 36: 1888.Google Scholar
  36. Department of Health and Social Security, 1979, Recommended Daily Amounts of Food Energy and Nutrients for groups of People in the United Kingdom. Report on Health and Social Subjects No. 15, H.M. Stationery Office, London.Google Scholar
  37. Dickerson, J. W. T., 1981, The role of enteral nutrition in malignant disease, Acta Chirg. Scand. Suppl. 507: 422.Google Scholar
  38. Dickerson, J. W. T., 1982, Vitamin C and cancer, in: Vitamin C ( J. N. Counsell and D. H. Hornig, eds.), pp 349–58, Applied Science Publishers, London.Google Scholar
  39. Dickerson, J. W. T., and Tredger, J., 1978, Nutrition and the rehabilitation of the cancer patient, in: Cancer Rehabilitation ( P. A. Downie, ed.), pp. 152–171, Faber & Faber, London.Google Scholar
  40. Dowling, R. H., 1967, Compensatory changes in intestinal absorption, Br. Med. Bull. 23: 275.Google Scholar
  41. Drasar, B. S., and Irving, D., 1973, Environmental factors and cancer of the colon and breast, Br. J. Cancer 27: 167.Google Scholar
  42. Fenninger, L. D., and Mider, G. B., 1954, Energy and nitrogen metabolism in cancer, Adv. Cancer Res. 2: 229.Google Scholar
  43. Fernstrom, J. D., 1977, Effect of the diet on brain neurotransmitters, Metabolism 26 (2): 207.Google Scholar
  44. Flynn, A., 1979, Copper metabolism in patients with solid tumours, in: Nutrition and Cancer (J. van Eys, M. S. Seelig, and B. L. Nichols, eds.), pp. 187–194, SP Medical and Scientific Books, New York.Google Scholar
  45. Fowell, E., Lee, H. A., and Dickerson, J. W. T., 1978, Intragastric tube feeds and elemental diets, in: Nutrition in the Clinical Management of Disease ( J. W. T. Dickerson and H. A. Lee, eds.), pp. 332–348, Arnold, London.Google Scholar
  46. Gorschein, D., 1977, Posthypophysectomy taste abnormalities: Their relationship to remote effects of cancer, Cancer 39: 1700.Google Scholar
  47. Hall, J. C., Staniland, J. R., and Giles, G. R., 1980, Altered taste thresholds in gastrointestinal cancer, Clin. Oncol. 6: 137.Google Scholar
  48. Harvey, K. B., Bothe, A., and Blackburn, G. L., 1979, Nutritional assessment and patient outcome during oncological therapy, Cancer 43: 2065.Google Scholar
  49. Hegedus, S., and Pelham, M., 1975, Dietetics in a cancer hospital, J. Am. Diet. Assoc. 67: 235.Google Scholar
  50. Henkin, R. I., Gill, J. R., and Bartter, F. C., 1963, Studies on taste thresholds in normal man and in patients with adrenal cortical insufficiency: The role of adrenal cortical steroids and the serum sodium concentration, J. Clin. Invest. 42: 727.Google Scholar
  51. Holland, J. C., Rowland, D. J., and Plumb, M., 1977, Psychological aspects of anorexia in cancer patients, Cancer Res. 37: 2425.Google Scholar
  52. Holroyde, C. P., Gabuzda, T. G., Putnam, R. C., Paul, P., and Reichard, G. A., 1975, Altered glucose metabolism in metastatic carcinoma, Cancer Res. 35: 3710.Google Scholar
  53. Ibrahim, K., Jaffarey, N. A., and Zuberi, S. J., 1972, Plasma vitamin A and carotene levels in squamous cell carcinoma of oral cavity and oro-pharynx, Clin. Oncol. 3: 203.Google Scholar
  54. Kark, J. D., Smith, A. H., Switzer, B. R., and Hames, C. G., 1981, Serum vitamin A (retinol) and cancer incidence in Evans County, Georgia, J. Natl. Cancer Inst. 66: 7.Google Scholar
  55. Krause, R., James, J. H., Ziparo, V., and Fischer, J. E., 1979, Brain tryptophan and the neoplastic anorexia-cachexia syndrome, Cancer 44: 1003.Google Scholar
  56. Lanzotti, V. C., Copeland, E. M., George, S. L., Dudrick, S. J., and Samuels, M. L., 1975, Cancer chemotherapeutic response and intravenous hyper-alimentation, Cancer Chemother. Rep. 59: 437.Google Scholar
  57. Lawrence, W., 1979, Effects of cancer on nutrition, Cancer 43: 2020.Google Scholar
  58. Leklem, J. E., Brown, R. R., Potera, C., and Becker, D. S., 1979, A role for vitamin B6 in cancer, in: Nutrition and Cancer ( J. van Eys, M. S. Seelig, and B. L. Nichols, eds.), pp. 249–261, SP Medical and Scientific Books, New York.Google Scholar
  59. Lundholm, K., Bylund, A.-C., and Scherstén, T., 1977, Glucose tolerance in relation to skeletal muscle enzyme activities in cancer patients, Scand. J. Clin. Lab. Invest. 37: 267.Google Scholar
  60. Lundholm, K., Holm, G., and Scherstén, T., 1978, Insulin resistance in patients with cancer, Cancer Res. 38: 4665.Google Scholar
  61. MacCarthy-Leventhal, E. M., 1959, Post-radiation mouth blindness, Lancet 2: 1138.Google Scholar
  62. Mallette, L. D., Bilezikian, J. P., Heath, D. A., and Aurbach, G. D., 1974, Primary hyperparathyroidism: Clinical and biochemical features, Medicine 53: 127.Google Scholar
  63. McAllister, R. A., Soukop, M., and Calman, K. C., 1976, Metabolic changes in liver of tumor-bearing animals, Br. J. Cancer 34: 312.Google Scholar
  64. McConnel, K. P., Jager, R. M., Higgins, P. J., and Blotcky, A. J., 1979, Serum selenium levels in patients with and without breast cancer, in: Nutrition and Cancer ( J. van Eys, M. S. Seelig, and B. L. Nichols, eds.), pp. 195–197, SP Medical and Scientific Books, New York.Google Scholar
  65. Mandel, M. A., and Kiehn, C. L., 1974, The prognostic significance of delayed cutaneous reactivity in head and neck cancer patients, Plast. Reconstr. Surg. 53: 72.Google Scholar
  66. Mariani, G., Strober, W., Keiser, H., et al.,1976, Pathophysiology of hypoalbuminaemia associated with carcinoid tumour, Cancer 38:854.Google Scholar
  67. Mider, G. B., Ailing, E. L., and Morton, J. J., 1950, The effect of neoplastic and allied diseases on the concentration of the plasma proteins, Cancer 3: 56.Google Scholar
  68. Morrison, S. D., 1979, Anorexia and the cancer patient, in: Nutrition and Cancer ( J. van Eys, M. S. Seelig, and B. L. Nichols, eds.), pp. 31–47, SP Medical and Scientific Books, New York.Google Scholar
  69. Mueller, P. S., and Watkins, D. M., 1961, Plasma unesterified fatty acid concentrations in neoplastic disease, J. Lab. Clin. Med. 57: 95.Google Scholar
  70. Murata, A., Morishige, F., and Yamaguchi, H., 1980, Prolongation of Survival Times in Terminal Human Cancer by Administration of Supplemented Ascorbate. Proc. Third International Vitamin C Symposium, Sao Paulo.Google Scholar
  71. Ohnuma, T., Holland, J. F., Nagel, G., and St. Arneault, G., 1969, Effects of L-aspàraginase in acute myelocytic leukaemia, J. Am. Med. Assoc. 210: 1919.Google Scholar
  72. Pagliardi, E., and Giangradni, E., 1960, Clinical significance of the blood copper in Hodgkin’s disease, Acta Haematol. 24: 201.Google Scholar
  73. Potera, C., Rose, D. P., and Brown, R. R., 1977, Vitamin B6 deficiency in cancer patients, Am. J. Clin. Nutr. 30: 1677.Google Scholar
  74. Powles, T. J., Rosset, G., Leese, C. L., and Bondy, P. K., 1976, Early morning hydroxyproline excretion in patients with breast cancer, Cancer 38: 2564.Google Scholar
  75. Rapp, G. W., 1973, Some systemic effects of malignant tumours. I. Co-enzyme A levels, Cancer 31: 357.Google Scholar
  76. Richards, J. R., and Kinney, J. M. (eds.), 1977, Nutritional Aspects of Care in the Critically Ill, Churchill–Livingstone, Edinburgh.Google Scholar
  77. Samuels, M. L., Lanzotti, W. J., Hologe, P. Y., Boyle, L. F., Smith, T. L., and Johnson, D. E., 1976, Combination chemotherapy in germinal cell tumours, Cancer Treat. Rev. 3: 185.Google Scholar
  78. Schein, P. S., Kisner, D., Haller, D., Blecher, M., and Hamoch, M., 1979, Cachexia of malignancy, Cancer 43: 2070.Google Scholar
  79. Schmale, A. H., 1979, Psychological aspects of anorexia, Cancer 43: 2087.Google Scholar
  80. Settle, R. G., Quinn, M. R., Brand, J. G., Kare, M. R., Mullen, J. L., and Brown, R., 1979, Gustatory evaluation of cancer patients: Preliminary results, in: Nutrition and Cancer ( J. van Eys, M. S. Seelig, and B. L. Nichols, eds.), pp. 171–185, SP Medical and Scientific Books, New York.Google Scholar
  81. Shamberger, R. J., and Frost, D. V., 1969, Possible protective effect of selenium against breast cancer, Can. Med. Assoc. J. 100: 682.Google Scholar
  82. Shamberger, R. J., and Willis, C. E., 1979, Vitamins and cancer—an overview, in: Nutrition and Cancer ( J. van Eys, M. S. Seelig, and B. L. Nichols, eds.), pp. 233–248, SP Medical and Scientific Books, New York.Google Scholar
  83. Shils, M. E., 1977, Nutritional problems associated with gastrointestinal and genitourinary cancer, Cancer Res. 37: 2366.Google Scholar
  84. Shils, M. E., and Gilaj, T., 1966, The effect of oesophagectomy on absorption in man: Clinical and metabolic observation, Gastroenterology 50: 347.Google Scholar
  85. Sjoerdsma, A., 1959, Serotonin, N. Engl. J. Med. 261: 181, 231.Google Scholar
  86. Smith, J. E., Brown, E. D., and Smith, J. C. Jr., 1974, The effect of zinc deficiency on the metabolism of retinol-binding protein in the rat, J. Lab. Clin. Med. 84: 692.Google Scholar
  87. Soukop, M., and Calman, K. C., 1979, Nutritional support in patients with malignant disease, J. Hum. Nutr. 33: 179.Google Scholar
  88. Sporn, M. B., Dunlop, N. M., Newton, D. L., and Smith, J. M., 1976, Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids), Fed Proc. 35: 1332.Google Scholar
  89. Steinfeld, J. L., 1960, I131 albumin degradation in patients with neoplastic disease, Cancer 13: 974.Google Scholar
  90. Theologides, A., 1979, Cancer cachexia, Cancer, 43: 2004.Google Scholar
  91. Tessmer, C. F., Hrgovcic, M., Brown, B. W., Wilbur, J., and Thomas, F. B., 1972, Serum copper correlations with bone marrow, Cancer 29: 173.Google Scholar
  92. Wahi, P. N., Kehar, U., and Lahiri, B., 1965, Factors influencing oral and oropharyngeal cancer in India, Br. J. Cancer 19: 646.Google Scholar
  93. Wald, N., Idle, M., Boreham, J., and Bailey, A., 1980, Low serum-vitamin A and subsequent risk of cancer. Preliminary results of a prospective study, Lancet 2: 813.Google Scholar
  94. Waldmann, T., Trier, J., and Fallon, H., 1963, Albumin metabolism in patients with lymphoma, J. Clin. Invest. 42: 171.Google Scholar
  95. Waldmann, T. A., 1977, Protein-losing enteropathy, in: Nutrition and Cancer ( M. Winick, ed.), Wiley, Chichester.Google Scholar
  96. Waldmann, T. A., Wochner, R. D., and Strober, W., 1969, The role of the gastrointestinal tract in plasma protein metabolism. Studies with 51Cr-albumin, Am. J. Med. 46: 275.Google Scholar
  97. Waldmann, T. A., Broder, S., and Strober, W., 1974, Protein losing enteropathies in malignancy, Ann. N.Y. Acad. Sci. 230: 306.Google Scholar
  98. Warnold, I., Lundholm, K., and Scherstén, T., 1978, Energy balance and body composition in cancer patients, Cancer Res. 38: 1801.Google Scholar
  99. Waterhouse, C., and Kemperman, J. H., 1971, Carbohydrate metabolism in subjects with cancer, Cancer Res. 31: 1273.Google Scholar
  100. Watkin, D. M., 1957, Depression of total body respiratory quotient in human malignant disease (Abstract), J. Clin. Invest. 36: 934.Google Scholar
  101. White, F. R., 1945, Source of tumor proteins. II. Nitrogen balance studies of tumor-bearing mice fed a low nitrogen diet, J. Natl. Cancer Inst. 5: 265.Google Scholar
  102. Wilkinson, A. W., and Cuthbertson, D. (eds.), 1976, Metabolism and the Response to Injury, Pitman Medical, Tonbridge Wells.Google Scholar
  103. Wilkoff, L. J., Peckham, J. C., Dulmadge, E. A., Mowry, R. W., and Chopra, D. P., 1976, Evaluation of vitamin A analog in medulating epithelial differentiation of 13 day chick embryo metatarsal skin explants, Cancer Res. 36: 964.Google Scholar
  104. Williams, L. R., Cohen, M. H., and Sewell, M. B., 1978, Altered taste thresholds in lung cancer, Am. J. Clin. Nutr. 31: 122.Google Scholar
  105. Wright, H. K., and Tilson, M. D., 1971, The short gut syndrome: Pathophysiology and treatment, in: Current Problems in Surgery ( M. M. Ravitch, ed.), Year Book Med. Publ., Chicago.Google Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • J. W. T. Dickerson
    • 1
  1. 1.Department of BiochemistryUniversity of SurreySurreyUK

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