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Cellular Retinol- and Retinoic Acid-Binding Proteins

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Advances in Nutritional Research

Part of the book series: Advances in Nutritional Research ((ANUR))

Abstract

In recent years considerable effort has been directed toward the detection, isolation, and characterization of intracellular proteins which specifically bind compounds with vitamin A activity. This interest was triggered by the discovery of a protein that specifically binds retinol (vitamin A alcohol). This protein was detected in soluble protein extracts of some vitamin A-sensitive organs (Bashor et al., 1973). Subsequently, a different protein, which specifically bound retinoic acid (vitamin A acid), was also discovered in extracts of various animal tissues (Ong and Chytil, 1975a; Sani and Hill, 1976). Interest in this field intensified as evidence for a role of these proteins in normal as well as malignant growth accumulated (Ong and Chytil 1975b; Chytil and Ong, 1976).

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Authors and Affiliations

  1. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232, USA

    Frank Chytil & David E. Ong

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  1. Frank Chytil
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  2. David E. Ong
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  1. University of Guelph, Guelph, Ontario, Canada

    Harold H. Draper

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© 1983 Springer Science+Business Media New York

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Chytil, F., Ong, D.E. (1983). Cellular Retinol- and Retinoic Acid-Binding Proteins. In: Draper, H.H. (eds) Advances in Nutritional Research. Advances in Nutritional Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-9937-7_2

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  • DOI: https://doi.org/10.1007/978-1-4613-9937-7_2

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  • Print ISBN: 978-1-4613-9939-1

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