The Influence of Dietary Fatty Acid Composition on Lipogenesis

  • Gene R. Herzberg
Part of the Advances in Nutritional Research book series (ANUR)


The steps involved in the conversion of nonlipid precursors into lipid are illustrated in Fig. 1 a. These steps may be conveniently divided into four parts:
  1. 1.

    Generation of cytoplasmic acetyl-CoA.

  2. 2.

    Conversion of acetyl-CoA to fatty acyl-CoA, predominantly palmitoylCoA.

  3. 3.

    Incorporation of fatty acyl-CoA into triglyceride.

  4. 4.

    Generation of NADPH for fatty acid synthesis by fatty acid synthetase.

Lipid synthesis and its regulation have been the subject of a number of recent reviews (Geelen et al.,1980; Freedland and Szepesi, 1971; Numa, 1974; Numa and Yamashita, 1974; Romsos and Leveille, 1974; Volpe and Vagelos, 1976). Readers who desire a more detailed treatment than presented below are advised to consult one or more of these reviews.


Fatty Acid Synthesis Malic Enzyme Lipogenic Enzyme Fatty Acid Synthetase Hepatic Lipogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Gene R. Herzberg
    • 1
  1. 1.Department of BiochemistryMemorial University of NewfoundlandSt. John’sCanada

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