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The Influence of Dietary Fatty Acid Composition on Lipogenesis

  • Gene R. Herzberg
Part of the Advances in Nutritional Research book series (ANUR)

Abstract

The steps involved in the conversion of nonlipid precursors into lipid are illustrated in Fig. 1 a. These steps may be conveniently divided into four parts:
  1. 1.

    Generation of cytoplasmic acetyl-CoA.

     
  2. 2.

    Conversion of acetyl-CoA to fatty acyl-CoA, predominantly palmitoylCoA.

     
  3. 3.

    Incorporation of fatty acyl-CoA into triglyceride.

     
  4. 4.

    Generation of NADPH for fatty acid synthesis by fatty acid synthetase.

     
Lipid synthesis and its regulation have been the subject of a number of recent reviews (Geelen et al.,1980; Freedland and Szepesi, 1971; Numa, 1974; Numa and Yamashita, 1974; Romsos and Leveille, 1974; Volpe and Vagelos, 1976). Readers who desire a more detailed treatment than presented below are advised to consult one or more of these reviews.

Keywords

Fatty Acid Synthesis Malic Enzyme Lipogenic Enzyme Fatty Acid Synthetase Hepatic Lipogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aas, M., and Daae, L. N. W., 1971, Fatty acid activation and acyltransfer in organs from rats in different nutritional states, Biochim. Biophys. Acta 239: 208.CrossRefGoogle Scholar
  2. Abraham, S., McGrath, H., and Rao, G. A., 1977, Stimulation of hepatic lipogenesis by eicosa-5,8,11,14-tetraynoic acid in mice fed a high linoleate diet, Lipids 12: 446.CrossRefGoogle Scholar
  3. Allee, G. L., O’Hea, E. K. Leveille, G. A., and Baker, D. H., 1971, Influence of dietary protein and fat on lipogenesis and enzymatic activity in pig adipose tissue, J. Nutr. 101: 1971.Google Scholar
  4. Allman, D. W., and Gibson, D. M., 1965, Fatty acid synthesis during early linoleic acid deficiency in the mouse, J. Lipid Res. 6: 51.Google Scholar
  5. Ashcraft, B. A., Fillers, W. S., Augistine, S. L., and Clarke, S. D., 1980, Polymer—protomer transition of acetyl—CoA carboxylase occurs in vivo and varies with nutritional conditions. J. Biol. Chem. 255: 10033.Google Scholar
  6. Balnave, D., and Pearce, J., 1969, Adaptation of laying hen (Gallus domesticus) to dietary fat with special reference to changes in liver and ovarian lipid content and liver enzyme activity, Comp. Biochem. Physiol. 29: 529.Google Scholar
  7. Bartley, J. C., and Abraham, S., 1972a, Dietary regulation of fatty acid synthesis in rat liver and hapatic autotransplants, Biochim. Biophys. Acta 260: 169.CrossRefGoogle Scholar
  8. Bartley, J. C., and Abraham, S., 1972b, Hepatic lipogenesis in fasted, re-fed rats and mice: Response to dietary fats of differing fatty acid composition, Biochim. Biophys. Acta 280: 258.CrossRefGoogle Scholar
  9. Bell, R. M., and Colemen, R. A., 1980, Enzymes of glycerolipid synthesis in eucaryotes, Annu. Rev. Biochem. 49: 459.CrossRefGoogle Scholar
  10. Bortz, W., Abraham, S., and Charkoff, I. L., 1963, Localization of the block in lipogenesis resulting from feeding fat, J. Biol. Chem. 238: 1266.Google Scholar
  11. Bottino, N. R., Anderson, R. E., and Raser, R., 1965, Dietary fatty acids: Their metabolic fate and influence on fatty acid biosynthesis, J. Am. Oil Chem. Soc. 42: 1124.CrossRefGoogle Scholar
  12. Brandes, R., Zohar, Y., Arad, R., and Shapiro, B., 1973, Two forms of microsomal palmitoyl-CoA synthetase, Eur. J. Biochem. 34: 329.CrossRefGoogle Scholar
  13. Brindley, D. N., 1978, Regulation of fatty acid esterification in tissues, in: Regulation of Fatty Acid and Glycerolipid Metabolism ( R. Dils and O. Knudsen, eds.), pp. 31–40, Pergamon, Oxford.Google Scholar
  14. Carlson, C. A., and Kim, K. H., 1974, Differential effects of metabolites on the active and inactive forms of hepatic acetyl CoA carboxylase, Arch. Biochem. Biophys. 164: 490.CrossRefGoogle Scholar
  15. Carrozza, G., Livrea, G., Caponetti, R., and Manasseri, L., 1979, Response of rat hepatic fatty acid synthesis and activities of related enzymes to changes in level of dietary fat, J. Nutr. 109: 162.Google Scholar
  16. Carroll, K. K., 1958, Digestibility of individual fatty acids in the rat, J. Nutr. 64: 399.Google Scholar
  17. Carroll, K. K., and Richards, J. F., 1958, Factors affecting digestibility of fatty acids in the rat, J. Nutr. 64: 411.Google Scholar
  18. Century, B., 1972, Effect of dietary lipid on various liver enzymes and on in vivo removal of 3,4dimethoxyphenylethylamine, 3,4 dihydroxyphenylalanine and 5-hydroxytryptophan in rats, J. Nutr. 102: 1067.Google Scholar
  19. Chu, L-C. McIntosh, D. J., Hincenbergs, I., and Williams, M. A., 1969, Dietary unsaturated fatty acids and liver fatty acid synthetase in rats, Biochim. Biophys. Acta 187: 573.Google Scholar
  20. Clarke, S. D., and Hillard, B. L., 1981, Suppression of hepatocyte fatty acid synthesis by albumin—bound linoleate involves depolymerization of acetyl—CoA carboxylase filaments. Lipids 16: 207.CrossRefGoogle Scholar
  21. Clarke, S. D., Romsos, D. R., and Leveille, G. A., 1976, Specific inhibition of hepatic fatty acid synthesis exerted by dietary linoleate and linolenate in essential fatty acid adequate rats, Lipids 11: 485.CrossRefGoogle Scholar
  22. Clarke, S. D., Romsos, D. R., and Leveille, G. A., 1977a, Differential effects of dietary methyl esters of long-chain saturated and polyunsaturated fatty acids on rat liver and adipose tissue lipogenesis, J. Nutr. 107: 1170.Google Scholar
  23. Clarke, S. D., Romsos, D. R., and Leveille, G. A., 1977b, Influence of dietary fatty acids on liver and adipose tissue lipogenesis and on liver metabolites in meal-fed rats, J. Nutr. 107: 1277.Google Scholar
  24. Clarke, S. D., Romsos, D. R., and Leveille, G. A., 1977c, Time sequence of changes in hepatic fatty acid synthesis in rats meal-fed polyunsaturated fatty acids, J. Nutr. 107: 1468.Google Scholar
  25. Coniglio, J. G., and Bridges, R., 1966, The effect of dietary fat on fatty acid synthesis in cell-free preparations of lactating mammary gland, Lipids 1: 76.CrossRefGoogle Scholar
  26. Demeyer, D. I., Tan, W. C., and Privett, O. S., 1974, Effect of essential fatty acid deficiency on lipid metabolism in isolated cells of epididymal fat pads of rats, Lipids 9: 1.CrossRefGoogle Scholar
  27. DiGiorgio, J., Bonanno, R. A., and Hegsted, D. M., 1962, Effect of diet upon the in vitro metabolism of rat epididymal adipose tissue, J. Nutr. 78: 384.Google Scholar
  28. Donaldson, W. E., 1968, Influence of dietary fatty acid composition on in vitro acetate incorporation into saturated vs. unsaturated and C16 vs. C18 fatty acids by coturnix quail, Comp. Biochem. Physiol. 27: 419.CrossRefGoogle Scholar
  29. Du, J. T., and Kruger, F. A., 1972, Effect of essential fatty acids on the fatty acid synthesis in epididymal fat cells of the rat, J. Nutr. 102: 1033.Google Scholar
  30. Dupont, J., 1970, Dietary lipid, fatty acid oxidation and incorporation of carbon into cholesterol, Lipids 5: 908.CrossRefGoogle Scholar
  31. Dupont, J., Spindler, A. A., and Mathias, M. M., 1978, Dietary fat saturation and cholesterol and fatty acid synthesis in aging rats, Age 1: 93.CrossRefGoogle Scholar
  32. Fallon, H. J., and Kemp, E. L., 1968, Effects of diet on hepatic triglyceride synthesis, J. Clin. Invest. 47: 712.Google Scholar
  33. Farid, M., Baldwin, R. L., Yang, Y. T., Osborne, E., and Grichting, G., 1978, Effects of age, diet and lactation of lipogenesis in rat adipose, liver and mammary tissues, J. Nutr. 108: 514.Google Scholar
  34. Farkas, T., Csengeri, I., Majoros, F., and Olah, J., 1978, Metabolism of fatty acids in fish. II Biosynthesis of fatty acids in relation to diet in the carp, Cyprinus carpis, tenaaeus 1758, Aquaculture 14: 57.CrossRefGoogle Scholar
  35. Flick, P. K., Chen, J., and Vagelos, P. R., 1977, Effect of dietary linoleate on synthesis and degradation of fatty acid synthetase from rat liver, J. Biol. Chem. 252: 4242.Google Scholar
  36. Freedland, R. A., and Szepesi, B., 1971, Control of enzyme activity: Nutritional factors, in: Enzyme Synthesis and Degradation in Mammalian Systems ( M. Rechcigl, ed.), pp. 103–140, Karger, Basel.Google Scholar
  37. Frenkel, R., 1975, Regulation and phyorological functions of malic enzymes, Curr. Top. Cell Regul. 9: 157.Google Scholar
  38. Geelen, M. J. H., Harris, R. A., Beynen, A. C., and McCund, S. A., 1980, Short-term hormonal control of hepatic lipogenesis, Diabetes 29: 1006.CrossRefGoogle Scholar
  39. Gibson, D. M., Lyons, R. T. Scott, D. F., and Muto, Y., 1972, Synthesis and degradation of the lipogenic enzymes of rat liver, Adv. Enzyme Regul. 10: 187.Google Scholar
  40. Glenny, H. P., Bowley, M., Burdett, S. L., Cooling, J., Pritchard, P. H., Sturton, R. G., and Brindley, D. N., 1978, The effect of dietary carbohydrate and fat on the activities of some enzymes responsible for glycerolysid synthesis in rat liver, Biochem. J. 174: 535.Google Scholar
  41. Goodridge, A. G., 1969, The effects of dietary fat on fatty acid synthesis and malic enzyme activity in liver from growing chicks, Can. J. Biochem. 47: 743.CrossRefGoogle Scholar
  42. Goodridge, A. G., and Ball, E. G., 1967, Lipogenesis in the pigeon, in vivo studies, Am. J. Physiol. 213: 245.Google Scholar
  43. Gozukara, E. M., Frolich, M., and Holten, D., 1972, The effect of unsaturated fatty acids on the rate of synthesis of rat liver glucose-6-phosphate dehydrogenase, Biochim. Biophys. Acta 286: 155.CrossRefGoogle Scholar
  44. Grigor, M. R., and Warren, S. M., 1980, Dietary regulation of mammary lipogenesis in lactating rats, Biochem. J. 188: 61.Google Scholar
  45. Guo, L. S. S., and Alexander, J. C., 1974, Effect of geometric isomers of A9-octadecenoic acid on liver lipid brosynthesis by essential fatty acid deficient rats, Biochim. Biophys. Acta 369: 411.CrossRefGoogle Scholar
  46. Guynn, R. W., Veloso, D., and Veech, R. L., 1972, The concentration of malonyl-coenzyme A and the control of fatty acid synthesis in vivo, J. Biol. Chem. 247: 7325.Google Scholar
  47. Hajra, A. K., 1968a, Biosynthesis of phosphatidic acid from dihydroxy-acetone phosphate, Biochem. Biophys. Res. Commun. 33: 929.CrossRefGoogle Scholar
  48. Hajra, A. K., 1968b, Biosynthesis of acyldihydroxyacetone phosphate in guinea pig liver mitochondria, J. Biol. Chem. 243: 3458.Google Scholar
  49. Hajra, A. K., and Agranoff, B. W., 1968a, Acyl dihydroxyacetone phosphate. Characterization of a 32P-labelled lipid from guinea pig liver mitochondria, J. Biol. Chem. 243: 1617.Google Scholar
  50. Hajra, A. K., and Agranoff, B. W., 1968b, Reduction of palmitoyl dihydroxyacetone phosphate by mitochondria, J. Biol. Chem. 243: 3542.Google Scholar
  51. Hajra, A. K., Seguin, E. B., and Agranoff, B. W., 1968, Rapid labelling of mitochondrial lipids by labelled orthophosphate and adenosine triphosphate, J. Biol. Chem. 243: 1609.Google Scholar
  52. Halperin, M. L., Cheema-Dhaldi, S., Taylor, W. M., and Fritz, I. B., 1974, Role of the citrate transporter in the control of fatty acid synthesis, Adv. Enzyme Regul. 13: 435.CrossRefGoogle Scholar
  53. Hausberger, F. X., and Milstein, S. W., 1955, Dietary effects on lipogenesis in adipose tissue, J. Biol. Chem. 214: 483.Google Scholar
  54. Henderson, R. J., Christie, W. W., and Moore, J. H., 1979, Esterification of exogenous and endogenous fatty acids by cat adipocytes in vitro, Biochim. Biophys. Acta 573: 12.CrossRefGoogle Scholar
  55. Herzberg, G. R., and Janmohamed, N., 1980, Regulation of hepatic lipogenesis by dietary marge-oil or tripalmitin in the meal-fed mouse, Br. J. Nutr. 43: 571.CrossRefGoogle Scholar
  56. Herzberg, G. R., and Rogerson, M., 1981a, The role of dietary protein in hepatic lipogenesis in the young rat, Br. J. Nutr. 45: 259.CrossRefGoogle Scholar
  57. Herzberg, G. R., and Rogerson, M., 1981b, Dietary corn oil does not suppress the frustose induced increase in hepatic fatty acid synthesis, Nutr. Res. 1: 73.CrossRefGoogle Scholar
  58. Herzberg, G. R. and Rogerson, M., 1981c, Role for fatty acid binding protein in the regulation of hepatic lipogenesis by dietary linoleic acid, Nutr. Res. 1: 601.CrossRefGoogle Scholar
  59. Hill, R., Linazasoro, J. M., Chevallier, F., and Charkoff, I. L., 1958, Regulation of hepatic lipogenesis: The influence of dietary fats, J. Biol. Chem. 233: 305.Google Scholar
  60. Hill, R., Webster, W. W., Linazosoro, J. M., and Charkoff, I. L., 1960, Time occurrence of changes in liver’s capacity to utilize acetate for fatty acid and cholesterol synthesis after fat feeding, J. Lipid Res. 1: 150.Google Scholar
  61. Hillard, B. I., Lundin, P., and Clarke, S. D., 1980, Essentiality of dietary carbohydrate for maintenance of liver lipogenesis in the chick, J. Nutr. 110: 1533.Google Scholar
  62. Iritani, N., Fukuda, E., and Inoguchi, K., 1980, A possible role for Z protein in dietary control of hepatic triacylglycerol synthesis. J. Nutr. Sci. Vitaminol. 26: 271.CrossRefGoogle Scholar
  63. Iritani, N., Fukuda, E., Inoguchi, K., Tsubosaka, M., and Tashiro, S., 1980a, Reduction of lipogenic enzymes by shellfish triglycerides in rat liver, J. Nutr. 110: 1664.Google Scholar
  64. Iritani, N., Inoguchi, K., Endo, M., Fukuda, E., and Morita, M., 1980b, Identification of shellfish fatty acids and their effects on lipogenic enzymes, Biochim. Biophys. Acta 618: 378.CrossRefGoogle Scholar
  65. Jansen, G. R., Hutchison, C. F., and Zanetti, M. E., 1966, Studies on lipogenesis in vivo: Effect of dietary fat or starvation on conversion of [14C]glucose into fat and turnover of newly synthesized fat, Biochem. J. 99: 323.Google Scholar
  66. Jansen, G. R., Zanetti, M. E., and Hutchison, C. F., 1968, Studies on lipogenesis in vivo: Lipogenesis during extended periods of refeeding after starvation, Biochem. J. 106: 345.Google Scholar
  67. Jeffcoat, R., 1979, The biosynthesis of unsaturated fatty acids and its control in mammalian liver, Essays Biochem. 15: 1.Google Scholar
  68. Jeffcoat, R., and James, A. T., 1977, Interrelationship between the dietary regulation of fatty acid synthesis and the fatty acyl-CoA desaturases, Lipids 12: 469.CrossRefGoogle Scholar
  69. Jeffcoat, R., and James, A. T., 1978, The control of stearage-CoA desaturase by dietary linoleic acid, FEBS Lett. 85: 114.CrossRefGoogle Scholar
  70. Jeffcoat, R., Roberts, P. A., and James, A. T., 1979, The control of lipogenesis by dietary linoleic acid and its influence on the deposition of fat, Eur. J. Biochem. 101: 447.CrossRefGoogle Scholar
  71. Joly, J. G., Frennan, L., Ishir, H., and Lieber, C. S., 1973, Effect of chronic ethanol feeding on hepatic microsomal glycerophosphate acyltransferase activity, J. Lipid Res. 14: 337.Google Scholar
  72. Kamiryo, T., Nishikaura, Y., Mishina, M., Terao, M., and Numg, S., 1979, Involvement of long-chain acyl coenzyme A for lipid synthesis in repression of acetyl-CoA carboxylase in Candida lipolytica, Proc. Natl. Acad. Sci. USA 76: 4390.CrossRefGoogle Scholar
  73. Kitajima, K., Tashiro, S., and Numa, S., 1975, Acetyl-coenzyme-A carboxylase in cultured hepatocytes: Effects of exogenous fatty acids on the content, synthesis and degradation of the enzyme, Eur. J. Biochem. 54: 373.CrossRefGoogle Scholar
  74. Kobayashi, K., and Kanoh, H., 1979, Effect of even-and odd-numbered saturated fatty acids on glycerolipid synthesis in rat liver slices, Biochim. Biophys. Acta 575: 350.CrossRefGoogle Scholar
  75. Leveille, G. A., 1967a, Influence of dietary fat and protein on metabolic and enzymatic activities in adipose tissue of meal-fed rats, J. Nutr. 91: 25.Google Scholar
  76. Leveille, G. A., 1967b, Influence of dietary fat level on the enzymatic and lipogenic adaptations in adipose tissue of meal-fed rats, J. Nutr. 91: 267.Google Scholar
  77. Leveille, G. A., O’Hea, E. K., and Chakrabarty, K., 1968, In vivo lipogenesis in the domestic chicken, Proc. Soc. Exp. Biol. Med. 128: 298.Google Scholar
  78. Linn, T. C., and Srere, P. A., 1980, Coenzyme A requirement for the termination reaction of rat liver fatty acid synthetase, J. Biol. Chem. 255: 10676.Google Scholar
  79. Linn, T. C., Petit, F. H., and Reed, L. J., 1969, a-Keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation, Proc. Natl. Acad. Sci. USA 62: 234.Google Scholar
  80. Lin, H., Romsos, D. R., Tack, P. 1., and Leveille, G. A., 1977a, Influence of dietary lipid on lipogenic enzyme activities in Coho salmon, Oncorhynchus kisutch (Walbaum), J. Nutr. 107: 846.Google Scholar
  81. Lin, H., Romsos, D. R., Tack, P. I., and Leveille, G. A., 1977b, Effects of fasting and feeding various diets on hepatic lipogenic enzyme activities in Coho salmon (Oncorhynchus kisutch (Walbaum), J. Nutr. 107: 1477.Google Scholar
  82. Linn, T. C., Stark, M. J., and Srere, P. A., 1980, Coenzyme A is required for rat liver fatty acid synthetase, J. Biol. Chem. 255: 1388.Google Scholar
  83. Liou, G. I., and Donaldson, W. E., 1973, Relative activities of acetyl-CoA carboxylase and fatty acid synthetase in chick liver: Effects of dietary fat, Can. J. Biochem. 51: 1029.CrossRefGoogle Scholar
  84. Lippel, K., 1971, Regulation of acyl-CoA synthetase, Biochim. Biophys. Acta 239: 384.CrossRefGoogle Scholar
  85. Lizarbe, M. A., Megras, A., Municio, A. M., and Olleros, T., 1980, Regulation of lipogenic enzymes by dietary unsaturated fatty acids in Ceratitis capitata larvae, Comp. Biochem. Physiol. 658: 687.Google Scholar
  86. Lloyd-Davies, K. A., and Brindley, D. N., 1975, Palmitate activation and esterification in the microsomal fractions of rat liver, Biochem. J. 152: 39.Google Scholar
  87. Lunzer, M. A., Manning, J. A., and Ockner, R. K., 1977, Inhibition of rat liver acetyl CoA carboxylase by long chain acyl coenzyme A and fatty acid, J. Biol. Chem. 252: 5483.Google Scholar
  88. Masoro, E. J., Charkoff, I. L., Chernick, S. S., and Felts, J. M., 1950, Previous nutritional state and glucose conversion to fatty acids in liver slices, J. Biol. Chem. 185: 845.Google Scholar
  89. McGarry, J. D., and Foster, D. W., 1980, Regulation of hepatic fatty acid oxidation and ketone body production, Annu. Rev. Biochem. 49: 395.CrossRefGoogle Scholar
  90. Musch, K., Ojakian, M., and Williams, M. A., 1974, Comparison of a-linolenate and oleate in lowering activity of lipogenic enzymes in rat liver: Evidence for a greater effect of dietary linolenate independent of food and carbohydrate intake, Biochim. Biophys. Acta 337: 343.CrossRefGoogle Scholar
  91. Muto, Y., and Gibson, D. M., 1970, Selective dampening of lipogenic enzymes of liver by exogenous polyunsaturated fatty acids, Biochem. Biophys. Res. Commun. 38: 9.CrossRefGoogle Scholar
  92. Muto, Y., Shenohara, N., Banphotkasem, S., Iitoyo, N., and Hosoya, N., 1975, Effect of exogenous polyunsaturated fatty acids on lipogenic enzyme activity in rat liver under fixed carbohydrate consumption, J. Nutr. Sci. Vitaminol. 21: 39.CrossRefGoogle Scholar
  93. Nace, C. S., and Szepesi, B., 1976, Dietary fatty acids and the control of glucose-6-phosphate dehydrogenase and malic enzyme in the starved-refed rat, J. Nutr. 106: 1976.Google Scholar
  94. Nace, C. S., and Szepesi, B., 1977, Response of glucose-6-phosphate dehydrogenase and malic enzyme in rat liver and adipose tissue to dietary medium and long-chain triglycerides, J. Nutr. 107: 934.Google Scholar
  95. Nace, C. S., Szepesi, B., and Michaelis, O. E., 1979, Regulation of glucose-6-phosphate dehydrogenase and malic enzyme in liver and adipose tissue: Effect of dietary linolein level in starved-refed and ad libitum-fed rats, J. Nutr. 109: 1094.Google Scholar
  96. Nilsson, A., Sundler, R., and Akesson, B., 1974, Effect of different albumin-bound fatty acids on fatty acid and cholesterol biosynthesis in rat hepatocytes, FEBS Lett. 45: 282.CrossRefGoogle Scholar
  97. Nishikori, K., Iritani, N., and Numa, S., 1973, Levels of acetyl coenzyme A carboxylase and its effectors in rat liver after short-term fat-free refeeding, FEBS Lett. 32: 19.CrossRefGoogle Scholar
  98. Numa, S., 1974, Regulation of fatty-acid synthesis in higher animals, Ergeb. Physiol. 69:53. Numa, S., and Yamashita, S., 1974, Regulation of lipogenesis in animal tissues, Curr. Top. Cell Regul. 8: 197.Google Scholar
  99. O’Hea, E. K., and Leveille, G. A., 1968, Lipogenesis in isolated adipose tissue of the domestic chick (Gallus domesticus), Comp. Biochem. Physiol. 26: 111.CrossRefGoogle Scholar
  100. O’Hea, E. K., and Leveille, G. A., 1969, Lipid biosynthesis and transport in the domestic chick (Gallus domesticus), Comp. Biochem. Physiol. 30: 149.CrossRefGoogle Scholar
  101. Pande, S. V., and Parvin, R., 1978, Pyruvate and aceto acetate transport in mitochondria, J. Biol. Chem. 253: 1565.Google Scholar
  102. Pande, S. V., Khan, R. P., and Nenkitasubramanian, T. A., 1964, Nicotinamide adenine dinneleotide phosphate-specific dehydrogenases in relation to lipogenesis, Biochim. Biophys. Acta 84: 239.Google Scholar
  103. Pearce, J., 1968, The effect of dietary fat on lipogenic enzymes in the liver of the domestic fowl, Biochem. J. 109: 702.Google Scholar
  104. Rao, G. A., Sorrels, M. F., and Reiser, R., 1971, Dietary regulation of phosphatidate synthesis from dihydroxyacetone phosphate and fatty acid by rat liver microsomes, Lipids 6: 88.CrossRefGoogle Scholar
  105. Reiser, R., Williams, M. C., Sorrels, M. F., and Murty, N. L., 1963, Biosynthesis of fatty acids and cholesterol as related to diet fat, Arch. Biochem. Biophys. 102: 276.CrossRefGoogle Scholar
  106. Romsos, D. R., and Leveille, G. A., 1974, Effect of diet on activity of enzymes involved in fatty acid and cholesterol synthesis, Adv. Lipid Res. 12: 97.Google Scholar
  107. Romsos, D. R., Ruy, S. M., and Leveille, G. A., 1976, Influence of dietary fat source on hepatic lipogenesis in the fasted-refed chick (Gallus domesticus), Comp. Biochem. Physiol. B 53: 19.Google Scholar
  108. Romsos, D. R., Muiruri, K. L., Lin, P-Y., and Leveille, G. A., 1978, Influence of dietary fat, fasting and acute premature weaning on in vivo rates of fatty acid synthesis in lactating mice, Proc. Soc. Exp. Biol. Med. 159: 308.CrossRefGoogle Scholar
  109. Rudack, D., Chisolm, E. M., and Holten, D., 1971, Rat liver glucose-6-phosphate dehydrogenase. Regulation by carbohydrate diet and insulin, J. Biol. Chem. 246: 1249.Google Scholar
  110. Sabine, J. R., McGrath, H., and Abraham, S., 1969, Dietary fat and inhibition of hepatic lipogenesis in the mouse, J. Nutr. 98: 312.Google Scholar
  111. Smith, S., and Abraham, S., 1970, Fatty acid synthesis in developing mouse liver, Arch. Biochem. Biophys. 136: 112.CrossRefGoogle Scholar
  112. Smith, S., Gagne, H. T., Pitelka, D. R., and Abraham, S., 1969, The effect of dietary fat on lipogenesis in mammary gland and liver from lactating and virgin mice, Biochem. J. 115: 807.Google Scholar
  113. Soler-Argelaga, C., Infante, R., and Polonouski, J., 1973, Influence of chain length and degree of unsaturation on plasma free fatty acid uptake by the perfused rat liver, Biochim. Biophys. Acta 326: 167.CrossRefGoogle Scholar
  114. Sullivan, A. C., Hamilton, J. G., Miller, O. N., and Wheatley, V. R., 1972, Inhibition of lipogenesis in rat liver by (-)-hydroxycitrate, Arch. Biochem. Biophys. 150: 183.CrossRefGoogle Scholar
  115. Tanabe, T., Wada, K., Oguwara, H., and Numa, S., 1977, Effects of allosteric effectors on proteolysis of rat liver acetyl-CoA carboxylase by lysosomal extracts, FEBS Lea. 82: 85.CrossRefGoogle Scholar
  116. Tepperman, H. M., and Tepperman, J., 1965, Effect of saturated fat diets on rat liver NADP-linked enzymes, Am. J. Physiol. 209: 773.Google Scholar
  117. Toorop, A., Romsos, D. R., and Leveille, G. A., 1979, The metabolic fate of dietary 1–14C-linoleate and 1–14C-palmitate in meat fed rats, Proc. Soc. Exp. Biol. Med. 160: 312.CrossRefGoogle Scholar
  118. Toussant, M. J., Hillard, B., and Clarke, S. D., 1979, Inhibition of lipogenesis by polyunsaturated fatty acids, Fed. Proc. 38: 705.Google Scholar
  119. Toussant, M. J., Wilson, M. D., and Clarke, S. D., 1981, Coordinate suppression of liver acetylCoA carboxylase and fatty acid synthetase by polyunsaturated fat, J. Nutr. 111: 146.Google Scholar
  120. Triscari, J., Hamilton, J. G., and Sullivan, A. C., 1978, Comparative effects of saturated and unsaturated lipids on hepatic lipogenesis and cholesterogenesis in vivo in the meal-fed rat, J. Nutr. 108: 815.Google Scholar
  121. Triscari, J., Ontko, J. A., and Sullivan, A. C., 1980, Comparison of nutritional influences on rat hepatic lipid synthesis in isolated cells and in vivo, Nut. Rep. Int. 21: 269.Google Scholar
  122. Tsai, C. S., Burgett, M. W., and Reed, L., 1973, a-Keto acid dehydrogenase complexes. XX. A kinetic study of the pyruvate dehydrogenase complex from bovine kidney, J. Biol. Chem. 248: 8348.Google Scholar
  123. Veech, R. L., and Guynn, R. W., 1974, The control of hepatic fatty acid synthesis in vivo, in: Regulation of Hepatic Metabolism ( F. Lundquist and N. Tygstrup, eds.), pp. 17–42, Pergamon, Oxford.Google Scholar
  124. Vernon, R. G., 1975, Effect of dietary safflower oil upon lipogenesis in neonatal lamb, Lipids 10: 284.CrossRefGoogle Scholar
  125. Vernon, R. G., 1977, Effect of different fatty acids on lipogenesis in rat and sheep adipose tissue in vitro, Int. J. Biochem. 8: 517.CrossRefGoogle Scholar
  126. Volpe, J. J.,and Vagelos, P. R., 1976, Mechanisms and regulation of biosynthesis of saturated fatty acids, Physiol. Rev. 56:339.Google Scholar
  127. Waterman, R. A., Romsos, D. R., Tsai, A. C., Miller, E. R., and Leveille, G. A., 1975, Influence of dietary safflower oil and tallow on growth, plasma lipids and lipogenesis in rats, pigs and chicks, Proc. Soc. Exp. Biol. Med. 150: 347.CrossRefGoogle Scholar
  128. Weiss, J. F., Naber, E. C., and Johnson, R. M., 1967, Effect of dietary fat and cholesterol on the in vitro incorporation of acetate-14C into hen liver and ovarian lipids, J. Nutr. 93: 142.Google Scholar
  129. Whitney, J. E., and Roberts, S., 1955, Influence of previous diet on hepatic glycogenesis and lipogenesis, Am. J. Physiol. 180: 446.Google Scholar
  130. Wiegand, R. D., Rao, G. A., and Reiser, R., 1973, Dietary regulation of fatty acid synthetase and microsomal glycerophosphate acyl-transferase activities in the rat, J. Nutr. 103: 1414.Google Scholar
  131. Weiland, O., and Siess, E., 1970, Intercoversion of phospho-and dephospho-forms of pig heart pyruvate dehydrogenase, Proc. Natl. Acad. Sci. USA 65: 947.CrossRefGoogle Scholar
  132. Winegrad, A. I., and Renold, A. E., 1958, Studies on rat adipose tissue in vitro. II. Effects of insulin on the metabolism of specifically labelled glucose, J. Biol. Chem. 233: 273.Google Scholar
  133. Wolfe, R. G., and Holten, D., 1978, The effect of dietary fat or cholesterol and cholic acid on the rate of synthesis of rat liver glucose-6-phosphate dehydrogenase, J. Nutr. 108: 1708.Google Scholar
  134. Yamashita, S., and Numa, S., 1972, Partial purification and properties of glycerophosphate acyl transferase from rat liver, Eur. J. Biochem. 31: 565.CrossRefGoogle Scholar
  135. Yamashita, S., Hosaka, K., and Numa, S., 1972, Resolution and reconstitution of the phosphatidate synthesizing system of rat liver microsomes, Proc. Natl. Acad. Sci. USA 69: 3490.CrossRefGoogle Scholar
  136. Yang, Y.-T., and Williams, M. A., 1978a, Comparison of C18- and C20-unsaturated fatty acids in reducing fatty acid synthesis in isolated rat hepatocytes, Fed. Proc. 37: 446.Google Scholar
  137. Yang, Y.-T., and Williams, M. A., 1978b, Comparison of C78-, C20- and C22-unsaturated fatty acids in reducing fatty acid synthesis in isolated rat hepatocytes, Biochim. Biophys. Acta 531: 133.CrossRefGoogle Scholar
  138. Yeh, Y.-Y., Leveille, G. A., and Wiley, J. H., 1970, Influence of dietary lipid on lipogenesis and on the activity of malic enzyme and citrate cleavage enzyme in liver of the growing chick, J. Nutr. 100: 917.Google Scholar
  139. Yugari, Y., and Matsuda, T., 1967, Glucose-6-phosphate dehydrogenase from rat liver. II. Effect of diet on enzyme activity in vivo and inhibition by long chain fatty acids in vitro, J. Biochem. 61: 541.Google Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Gene R. Herzberg
    • 1
  1. 1.Department of BiochemistryMemorial University of NewfoundlandSt. John’sCanada

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