The Role of Copper and Zinc in Cholesterol Metabolism

  • Leslie M. Klevay
Part of the Advances in Nutritional Research book series (volume 1)


Ischemic heart disease is the leading cause of death in the United States (Anonymous, 1974a). Previously termed coronary heart disease (Anonymous, 1969), this disease causes about 35% of deaths, twice as many as are caused by malignant neoplasms or cancer. In the United States, risk of ischemic heart disease is higher among men than among women, among smokers of cigarettes than among nonsmokers, among diabetics and among those with certain abnormalities of the electrocardiogram. Risk also increases with age, with blood pressure, and with the concentration of cholesterol in serum (Insull, 1973). The predictive utility of the concentration of cholesterol in serum or plasma (Fredrickson and Levy, 1972) and the identification of many dietary components that can alter these concentrations have been the sources of most interest among nutritionists in the metabolism of cholesterol.


Coronary Heart Disease Ischemic Heart Disease Serum Cholesterol Phytic Acid Zinc Deficiency 
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© Plenum Press, New York 1977

Authors and Affiliations

  • Leslie M. Klevay
    • 1
  1. 1.Agricultural Research ServiceHuman Nutrition Laboratory, United States Department of AgricultureGrand ForksUSA

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