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Metal-Complex-Catalyzed Cleavage of Biopolymers

  • Chapter
Active Oxygen in Biochemistry

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Abstract

Oxygen radical species such as the superoxide (O -2 ), hydroxyl (· OH), and hydroperoxyl (· OOH) radicals are well known for their deleterious effects in living systems. Their buildup leads to oxidative stress, initiating lipid peroxidation, protein oxidation, DNA damage, and other cellular disorders (Fontecave and Pierre, 1991; Halliwell and Aruoma, 1991; Stadtman and Oliver, 1991) (see also Chapter 7) . For example, site-specific generation of radicals plays a major role in carcinogenesis. The highly reactive · OH radicals act on DNA by abstracting H atoms from the deoxyribose sugar-phosphate backbone, causing strand scission and the release of bases and producing “alkali-labile” sites (strand breakage occurs on addition of base). Hydroxyl radicals can also add to DNA bases, forming radical adducts, which can undergo further chemical reactions. These changes to the DNA can lead to harmful mutations.

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Authors
  1. Rosemary A. Marusak
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  2. Claude F. Meares
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Editors and Affiliations

  1. University of California, Los Angeles, USA

    Joan Selverstone Valentine  & Christopher S. Foote  & 

  2. University of North Carolina at Charlotte, USA

    Arthur Greenberg

  3. University of Maryland Baltimore County, USA

    Joel F. Liebman

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© 1995 Springer Science+Business Media New York

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Marusak, R.A., Meares, C.F. (1995). Metal-Complex-Catalyzed Cleavage of Biopolymers. In: Valentine, J.S., Foote, C.S., Greenberg, A., Liebman, J.F. (eds) Active Oxygen in Biochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-9783-0_8

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  • DOI: https://doi.org/10.1007/978-1-4613-9783-0_8

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  • Online ISBN: 978-1-4613-9783-0

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