Bioaccumulation and Toxicology of Chromium: Implications for Wildlife

Conference paper
Part of the Reviews of Environmental Contamination and Toxicology book series (RECT, volume 130)


Ore deposits containing chromium are heavily exploited for use in a variety of industrial processes. South Africa, the USSR, the Philippines, and Zimbabwe are the main producers of chromite ore (Ellis 1986). Annual world production of chromite is approximately 7 × 106 tons, roughly three orders of magnitude greater than natural rates of environmental mobilization (Eisler 1986). The largest users of Cr are the metallurgical and chemical industries (Langard and Norseth 1979). Most Cr for metallurgical purposes is used in stainless steel production and electroplating, whereas the chemical industry produces Cr compounds for incorporation into a diverse array of products including paint pigments, catalysts, wood preservatives, and tanning agents.


Sewage Sludge Hexavalent Chromium Salt Gland Chromium Trioxide Sodium Chromate 
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  1. Al-Shamma KJ, Hewitt PJ, Hicks R (1979) The elimination and distribution of components of welding fumes from lung deposits in the guinea pig. Ann Occup Hyg 22:33–41.PubMedCrossRefGoogle Scholar
  2. Anderlini VC, Connors PG, Riseborough RW, Martin JH (1971) Concentrations of heavy metals in some Antarctic and North American sea birds. In: Parker BC (ed) Proceedings of colloquium on conservation problems in Antarctica. Allen Press, Blacksburg, Va., pp 49–61.Google Scholar
  3. Anderson RA, Polansky MM, Bryden NA, Patterson KY, Veillon C, Glinsmann WH (1983) Effects of chromium supplementation on urinary Cr excretion of human subjects and correlation of Cr excretion with selected clinical parameters. J Nutr 113:276–281.PubMedGoogle Scholar
  4. Anderson RA, Kozlovsky AS (1985) Chromium intake, absorption and excretion of subjects consuming self-selected diets. Am J Clin Nutr 41:1177–1182.PubMedGoogle Scholar
  5. Anderson RA, Bryden NA, Polansky MM, Richards MP (1989) Chromium supplementation of turkeys: Effects on tissue chromium. J Agrie Food Chem 37:131–134.CrossRefGoogle Scholar
  6. Andren AW, Fortescue JAC, Henderson GS, Reichle DE, Van Hook RI (1973) Environmental monitoring of toxic materials in ecosysems. In: Ecology and analysis of trace contaminants. Oak Ridge Natl Lab prog rept, June 1972-Jan 1973, pp 61–120.Google Scholar
  7. Anthony RG, Kozlowski R (1982) Heavy metals in tissues of small mammals inhabiting waste-water-irrigated habitats. J Environ Qual 11:20–22.CrossRefGoogle Scholar
  8. Anwar RA, Langham CF, Hoppert CA, Alfredson BV, Byerrum RO (1961) Chronic toxicity studies. III. Chronic toxicity of cadmium and chromium in dogs. Arch Environ Hlth 3:456–467.Google Scholar
  9. Baetjer AM (1956) Relation of chromium to health. In: Udy M J (ed) Chromium. ACS Monograph Series, No. 132, Washington, D.C., pp 76–104.Google Scholar
  10. Baetjer AM, Damron C, Budacz V (1959) The distribution and retention of chromium in men and animals. Arch Ind Hlth 20:136–150.Google Scholar
  11. Bartlett R, James B (1979) Behaviour of chromium in soils: III. Oxidation. J Environ Qual 8:31–35.CrossRefGoogle Scholar
  12. Beardsley A, Vagg MJ, Beckett PH, Sansom BF (1978) Use of the field vole (M. agrestis) for monitoring potentially harmful elements in the environment. Environ Pollut 16:65–71.CrossRefGoogle Scholar
  13. Berggren P, Flatt PR (1985) Effects of trivalent chromium administration on endogenous chromium stores in lean and obese hyperglycaemic (ob/ob) mice. Nutr Rep Int 31:213–218.Google Scholar
  14. Bergkvist B, Folkeson L, Berggren D (1989) Fluxes of Cu, Zn, Cd, Cr, and Ni in temperate forest ecosystems. Water Air Soil Pollut 47:217–286.CrossRefGoogle Scholar
  15. Beyer WN, Miller G, Simmers JW (1990) Trace elements in soil and biota in confined disposal facilities for dredged material. Environ Pollut 65:19–32.PubMedCrossRefGoogle Scholar
  16. Blus LJ, Neely BS Jr, Lamont TG, Mulhern BM (1977) Residues of organochlorines and heavy metals in tissues and eggs of brown pelicans, 1969–1973. Pestic Monit J 11:40–53.PubMedGoogle Scholar
  17. Bowen HJM (1979) Environmental chemistry of the elements. Academic Press, London.Google Scholar
  18. Boyle E Jr, Mondschein B, Dash HH (1977) Chromium depletion in the pathogenesis of diabetes and atherosclerosis. South Med J 70:1449–1453.PubMedCrossRefGoogle Scholar
  19. Brard D (1935) Actualites scientifiques et industrielles; exposes de toxicologie et hygiene industrielle. In: Farbe R (ed) Toxicologie du chrome. Hermann and Cie, Paris, (as cited in NRCC 1976).Google Scholar
  20. Brooks RR (1987) Serpentine and its vegetation. Croom Helm, London.Google Scholar
  21. Burger J, Gochfeld M (1985) Comparisons of nine heavy metals in salt gland and liver of greater scaup (Aythya marila), black duck (Anas rubripes), and mallard (A. platyrhynchos). Comp Biochem Physiol 81C:287–292.Google Scholar
  22. Campa H III, Woodyard DK, Haufler JB (1986) Deer and elk use of forages treated with municipal sewage sludge. In: Cole DW, Henry CL, Nutter L (eds) The forest alternative for treatment and utilization of municipal and industrial wastes. Univ of Washington Press, Seattle, Wash., pp 188–198.Google Scholar
  23. Campbell PGC, Lewis AG, Chapman PM, Crowder AA, Fletcher WK, Imber B, Luoma SN, Stokes PM, Winfrey M (1988) Biologically available metals in sediments. Natl Res Council Can Publ No 27694, Ottawa, Canada. 298 pp.Google Scholar
  24. Cary EE, Allaway WH, Olson OE (1977) Control of chromium concentrations in fpod plants. I. Absorption and translocation of chromium by plants. J Agrie Food Chem 25:300–304.CrossRefGoogle Scholar
  25. Cary EE (1982) Chromium in air, soil and natural waters. In: Langard S (ed) Biological and environmental aspects of chromium. Elsevier Biomedical, Amsterdam, The Netherlands, pp 49–64.Google Scholar
  26. Casey CE, Hambridge KM (1980) Trace element deficiencies in man. Adv Nutr Res 3:23–63.Google Scholar
  27. CAST (Council for Agricultural Science and Technology) (1976) Application of sewage sludge to cropland: Appraisal of potential hazards of the heavy metals to plants and animals. EPA-430/9–76–013, Gen Serv Admin, Denver, Colo., 63 pp.Google Scholar
  28. Celotti L, Furlan D, Seccati L, Levis AG (1988) Interactions of nitrilotriacetic acid (NTA) with Cr (VI) compounds in the induction of gene mutations in cultured mammalian cells. Sci Total Environ 71:567.CrossRefGoogle Scholar
  29. Chen NSC, Tsai A, Dyer LA (1973) Effect of chelating agents on chromium absorption in rats. J Nutr 103:1182–1186.PubMedGoogle Scholar
  30. Chen Y, Stoddard-Gilbert K, Blincoe C (1989) Chromium in the gastrointestinal tract of the rat. J Sci Food Agrie 47:33–41.CrossRefGoogle Scholar
  31. Clark EGC, Clark ML (1975) Veterinary toxicology. Williams and Wilkins, Baltimore, Md., pp 55–56.Google Scholar
  32. Connors PG, Anderlini VC, Risebrough RW, Gilbertson M, Hays H (1975) Investigation of heavy metals in common tern populations. Can Fid Nat 89:157–162.Google Scholar
  33. Custer TW, Mulhern BL (1983) Heavy metal residues in prefledgling black-crowned night-herons from three Atlantic coast colonies. Bull Environ Contam Toxicol 30:178–185.PubMedCrossRefGoogle Scholar
  34. Custer TW, Franson JC, Moore JF, Myers JE (1986) Reproductive success and heavy metal contamination in Rhode Island common terns. Environ Pollut A41: 33–52.Google Scholar
  35. Danielsson BRG, Hassoun E, Dencker L (1982) Embryotoxicity of chromium: Distribution in pregnant mice and effects on embryonic cells in vitro. Arch Toxicol 51:233–245.Google Scholar
  36. De Flora S, Serra D, Camoirano A, Zanacchi P (1989) Metabolic reduction of chromium, as related to its carcinogenic properties. Biol Trace Elem Res 21: 179–187.PubMedCrossRefGoogle Scholar
  37. De Flora S, Bagnasco M, Serra D, Zanacchi P (1990) Genotoxicity of chromium compounds. A review. Mutat Res 238:99–172.PubMedGoogle Scholar
  38. Diaz-Mayans J, Laborda R, Nunez A (1986) Hexavalent chromium effects on motor activity and some metabolic aspects of Wistar albino rats. Comp Biochem Bio-phys 83:191–195.CrossRefGoogle Scholar
  39. Di Paulo JA, Casto BC (1979) Quantitative studies of in vitro morphological transformation of Syrian hamster cells by inorganic metal salts. Cancer Res 39:1008–1013.Google Scholar
  40. Donaldson RM, Barreras RF (1966) Intestinal absorption of trace quantities of chromium. J Lab Clin Med 68:484–493.PubMedGoogle Scholar
  41. Duinker JC, Hillebrand MTJ, Nolting RF (1979) Organochlorines and metals in harbour seals (Dutch Wadden Sea). Mar Pollut Bull 10:360–364.CrossRefGoogle Scholar
  42. Eastin WC Jr, Haseltine SD, Murray HC (1980) Intestinal absorption of 5 chromium compounds in young black ducks (Anas rubripes). Toxicol Lett 6:193–197.PubMedCrossRefGoogle Scholar
  43. EIFAC (European Inland Fisheries Advisory Committee) (1983) Water quality criteria for European freshwater fish: Report on chromium and freshwater fish. Tech Paper No 43, FAO, Rome.Google Scholar
  44. Eisler R (1986) Chromium hazards to fish, wildlife, and invertebrates: A synoptic review. U.S. Fish Wildlife Serv Biol Rept 85 (1.6), 60 pp.Google Scholar
  45. Elias Z, Poirot O, Pezerat H, Suquet H, Schneider O, Daniere MC, Terzetti F, Baruthio F, Fournier M, Cavelier C (1989) Cytotoxic and neoplastic transforming effects of industrial hexavalent chromium pigments in Syrian hamster embryo cells. Carcinogenesis 10:2043–2052.PubMedCrossRefGoogle Scholar
  46. Elliott JE, Scheuhammer AM, Leighton FA, Pearce PA (1992) Heavy metal and metallothionein concentrations in Atlantic Canadian seabirds. Arch Environ Contam Toxicol 22:63–73.PubMedCrossRefGoogle Scholar
  47. Ellis BG (1986) Chromium. In: Adriano DC (ed) Trace elements in the terrestrial environment. Springer-Verlag, New York, pp 155–180.Google Scholar
  48. Fishbein L (1981) Sources, transport and alterations of metal compounds: An overview. I. Arsenic, beryllium, cadmium, chromium, and nickel. Environ Hlth Perspect 40:43–64.CrossRefGoogle Scholar
  49. Fitzgerald PR, Peterson J, Lue-Hing C (1985a) Heavy metals in tissue of cattle exposed to sludge-treated pastures for eight years. Am J Vet Res 46:703–707.PubMedGoogle Scholar
  50. Fitzgerald PR, Peterson J, Lue-Hing C (1985b) Heavy metals in fluids and tissues of fetal calves and in young calves of nursing cows exposed or not exposed to anaerobically digested wastewater sludge. Am J Vet Res 46:165–168.PubMedGoogle Scholar
  51. Frobish LT (1980) Effect of protein source and chromium on turkey reproduction. Poult Sci 59:1610–1611.Google Scholar
  52. Gad SC, Powers WJ, Dunn BJ, Hoffman GM, et al. (1986) Acute toxicity of four Chromate salts. In: Serrone DM (ed) Chromium symposium 1986: An update. Industrial Hlth Foundation, Pittsburgh, Pa., pp 43–58.Google Scholar
  53. Gad SC (1989) Acute and chronic systemic chromium toxicity. Sci Total Environ 86:149–157.PubMedCrossRefGoogle Scholar
  54. Gale TF (1978) Embryotoxic effects of chromium trioxide in hamster. Environ Res 16:101–109.PubMedCrossRefGoogle Scholar
  55. Gale TF, Bunch JD (1979) The effect of the time of administration of chromium trioxide on the embryo toxic response in hamster. Teratology 19:81–86.PubMedCrossRefGoogle Scholar
  56. Gale TF (1982) The embryotoxic response to maternal chromium trioxide exposure in different strains of hamsters. Environ Res 29:196–203.PubMedCrossRefGoogle Scholar
  57. Gibb H, Chen C (1989) Evaluation of issues relating to the carcinogen risk assessment of chromium. Sci Total Environ 86:181–186.PubMedCrossRefGoogle Scholar
  58. Glaser U, Hochrainer D, Klöppel H, Kühnen H (1985) Low level chromium(VI) inhalation effects on alveolar macrophages and immune functions in Wistar rats. Arch Toxicol 57:250–256.PubMedCrossRefGoogle Scholar
  59. Gochfield M, Burger J (1987) Heavy metal concentrations in the liver of three duck species: Influence of species and sex. Environ Pollut 45:1–14.CrossRefGoogle Scholar
  60. Gregus Z, Klaassen CD (1986) Disposition of metals in rats: A comparative study of fecal, urinary and biliary excretion and tissue distribution of eighteen metals. Toxicol Appl Pharmacol 85:24–38.PubMedCrossRefGoogle Scholar
  61. Gross PR, Heller UG (1946) Chromium in animal nutrition. J Ind Hyg Toxicol 28: 52, (as cited in USPHS 1989).Google Scholar
  62. Gumbleton M, Nicholls PJ (1988) Dose-response and time-response biochemical and histological study of potassium dichromate-induced nephrotoxicity in the rat. Food Chem Toxicol 26:37–44.PubMedCrossRefGoogle Scholar
  63. Gurson CT (1977) The metabolic significance of dietary chromium. Adv Nutr Res 1:23–53.Google Scholar
  64. Haiford DK, Markham OD, White GC (1983) Biological elimination rates of radioisotopes by mallards contamined at a liquid radioactive waste disposal area. Hlth Phys 45:745–756.CrossRefGoogle Scholar
  65. Hansen PW (1987) Acid rain and waterfowl: The case for concern in North America. Izaak Walton League of America, Minneapolis, Minn., 39 pp.Google Scholar
  66. Haseltine SD, Mulhern BM, Stafford C (1980) Organochlorine and heavy metal residues in black duck eggs from Atlantic Flyway, 1978. Pestic Monit J 14:53–57.PubMedGoogle Scholar
  67. Heinz GH, Haseltine SD (1981) Avoidance behaviour of young black ducks treated with chromium. Toxicol Lett 8:307–310.PubMedCrossRefGoogle Scholar
  68. Hertel RF (1986) Sources of exposure and biological effects of chromium. In: O’Neill IK, Schuller P, Fishbein L (eds) Environmental carcinogens: Selected methods of analysis. Vol 8. IARC Sci Publ No 71, WHO, Lyons, France, pp 63–77.Google Scholar
  69. Howarth DM, Grant TR, Hulbert AJ (1982) A comparative study of heavy metal accumulation in tissues of the crested tern, Sterna bergii, breeding near an industrial port before and after harbour dredging and ocean dumping. Aust Wildlife Res 9:571–577.CrossRefGoogle Scholar
  70. Huckabee JW, Cartan FO, Kennington GS (1972) Environmental influence on trace elements in hair of 15 species of mammals. Oak Ridge Natl Lab, Environ Sci Div Rept ORNL-TM-3747 Oak Ridge Natl Lab, Tennessee, 36 pp.Google Scholar
  71. Huffman EWD, Allaway WH (1973) Chromium in plants: Distribution in tissues, organelles and extracts and availability of bean leaf chromium to animals. J Agrie Food Chem 21:982–986.CrossRefGoogle Scholar
  72. IARC (International Agency for Research on Cancer) (1982) IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. WHO, Lyon, Supplement 4, pp. 133–135.Google Scholar
  73. Iijima S, Matsumoto N, Lu CC, Katsunuma H (1975) Placental transfer of CrCl3 and its effects on fetal growth and development in mice. Teratology 12:198–205.Google Scholar
  74. Ivankovic S, Preussmann R (1975) Absence of toxic and carcinogenic effects after administrations of high doses of chromic oxide pigment in subacute and long term feeding experiments in rats. Food Cosmet Toxicol 13:347–351.PubMedCrossRefGoogle Scholar
  75. James BR, Bartlett RJ (1983) Behaviour of chromium in soils. VII. Adsorption and reduction of hexavalent forms. J Environ Qual 12:177–181.CrossRefGoogle Scholar
  76. Jaworski JF (1984) Chromium update 1984: Environmental and nutritional effects of chromium. Natl Res Council Can, Ottawa, 56 pp.Google Scholar
  77. Jenkins DW (1980) Biological monitoring of toxic trace metals. Vol 2. Toxic trace metals in plants and animals of the world. Part 1. USEPA Rept No 600/3–80–090, pp 364–443.Google Scholar
  78. Jennette KE (1982) Microsomal reduction of the carcinogen Chromate produces chromium(V). J Am Chem Soc 104:874.CrossRefGoogle Scholar
  79. Johansson A, Robertson B, Curstedt T, Camner P (1986) Rabbit lung after inhalation of hexa- and trivalent chromium. Environ Res 41:110–119.PubMedCrossRefGoogle Scholar
  80. Johansson A, Crustedt T, Jarstrand C, Robertson B, Camner P (1988) Effects on the rabbit lung of combined exposure to nickel and trivalent chromium. J Aerosol Sci 19:1075–1078.CrossRefGoogle Scholar
  81. Johansson A, Curstedt T, Robertson B, Camner P (1989) Lung lesions after experimental combined exposure to nickel and trivalent chromium. Environ Res 50: 103–119.PubMedCrossRefGoogle Scholar
  82. Kamiya N, Sakamoto Y, Nakao T, Hiraga K (1981) Inhalation experiment of chromite ore residue dust to rats for 7 days. (II) Analysis of chromium in rat tissues. Ann Rept Tokyo Metr Res Lab PH 32:85–88 (in Japanese, as cited in USPHS 1989).Google Scholar
  83. Kawanishi S, Inoue S, Sano S (1986) Mechanisms of DNA cleavage induced by sodium chromate(VI) in the presence of hydrogen peroxide. J Biol Chem 261: 5952–5958.PubMedGoogle Scholar
  84. Kayne FJ, Vanderlinde RE, Laboda HM (1982) Purification of a naturally-occurring chromium peptide from human urine. Clin Chem 28:1591.Google Scholar
  85. Kelsall JP (1970) Chemical elements in waterfowl flight feathers. Prog Notes Can Wildlife Serv 17:1–11.Google Scholar
  86. Kerndorff H, Schnitzer M (1980) Sorption of metals on humic acid. Geochim Cos-mochim Acta 44:1701–1708.CrossRefGoogle Scholar
  87. Kerr LA, Edwards WC (1981) Chromate poisoning in livestock from oil field wastes. Vet Hum Toxicol 23:401–402.PubMedGoogle Scholar
  88. Kobayashi H (1976) Toxicological studies on chromium. Acute toxicities of chromium trioxide. Tokyo Toritsu Eisei Kenkyusho Kenkyu Nempo 27:119–123 (as cited in USPHS 1989).Google Scholar
  89. Kovacikova Z (1990) Effect of environmental pollution from nickel smelter waste dump on the lung of rabbits. Two-generation study. Biologia 45:477–482.Google Scholar
  90. Kraintz L, Talmage RV (1952) Distribution of radioactivity following intravenous administration of trivalent chromium-51 in the rat and rabbit. Proc Soc Exp Biol Med 81:490–492.PubMedGoogle Scholar
  91. Kraus ML (1989) Bioaccumulation of heavy metals in pre-fledgling tree swallows, Tachycineta bicolor. Bull Environ Contam Toxicol 43:407–414.PubMedCrossRefGoogle Scholar
  92. Kreuzer W, Rosopulo A, Petry P, Schunemann D (1985) Chromium content of various edible tissues (muscle and organs) of slaughtered cows. Fleischwirt 65: 1255–1261.Google Scholar
  93. Laborda R, Diaz-Mayans J, Nunez A (1986) Nephrotoxic and hepatotoxic effects of chromium compounds in rats. Bull Environ Contamin Toxicol 36:332–336.CrossRefGoogle Scholar
  94. Lahouti M, Peterson PJ (1979) Chromium accumulation and distribution in crop plants. J Sci Food Agrie 30:136–142.CrossRefGoogle Scholar
  95. Lande E (1977) Heavy metal pollution in Trondheimsfjorden, Norway, and the recorded effects on the fauna and flora. Environ Pollut 12:187–198.CrossRefGoogle Scholar
  96. Langard S, Norseth T (1979) Chromium. In: Friberg L, Nordberg GF, Vouk VB (eds) Handbook on the toxicology of metals. Elsevier/North Holland Biomedical Press, Amsterdam, The Netherlands, pp 383–397.Google Scholar
  97. Langard S, Nordhagen A-L (1980) Small animal inhalation chambers and the significance of dust ingestion from the contaminated coat when exposing rats to zinc Chromate. Acta Pharmacol Toxicol 46:43–46.CrossRefGoogle Scholar
  98. Langard S (1982) Absorption, transport and excretion of chromium in man and animals. In: Langard S (ed) Biological and environmental aspects of chromium. Elsevier Biomedical, Amsterdam, The Netherlands, pp 149–170.Google Scholar
  99. Lehmann B (1914) Die Bedentung der Chromate fur die Gesundheit der Arbeiter, Schriften aus dem Gesamtgebeit der Gewerbehygiene, Vol 2, Part 1. Springer-Verlag, Berlin (as cited in NRCC 1976).Google Scholar
  100. Levis AG, Bianchi V (1982) Mutagenic and cytogenic effects of chromium compounds. In: Langard S (ed) Biological and environmental aspects of chromium. Elsevier Biomedical, Amsterdam, The Netherlands, pp 171–201.Google Scholar
  101. Levy L, Martin P (1986) An experimental investigation into the carcinogenicity of a range of chromium-containing materials. In: Serrone DM (ed) Chromium update 1986—an update. Industrial Hlth Foundation, Arlington, Va.Google Scholar
  102. Levy LS, Martin PA, Bidstrup PL (1986) Investigation of the potential carcinogenicity of a range of chromium containing materials on rat lung. Brit J Ind Med 43:243–256.Google Scholar
  103. Lewin L (1907) On poisoning by Cr compounds in industry. Chem Ztg 31:1706 (as cited in NRCC 1976).Google Scholar
  104. Liebross RH, Wetterhahn KE (1990) In vivo formation of chromium(V) in chick embryo red blood cells. Chem Res Toxicol 3:401–403.PubMedCrossRefGoogle Scholar
  105. Lim TH, Sargent T, Kusubov N (1983) Kinetics of trace element chromium(III) in the human body. Am J Physiol 244:R445-R454.PubMedGoogle Scholar
  106. Lyon GL, Peterson PJ, Brooks RR (1969) Chromium-51 distribution in tissues and extracts of Leptospermum scoparium. Planta 88:282–287.CrossRefGoogle Scholar
  107. MacKenzie RD, Byerrum RU, Decker CF, Hoppert CA, Langham RF (1958) Chronic toxicity studies. II. Hexavalent and trivalent chromium administered in drinking water to rats. Arch Ind Hlth 18:232–234.Google Scholar
  108. MacNaughton MG (1977) Adsorption of Cr(VI) at the oxide-water interface. In: Drucker H, Wildung RE (eds) Biological implications of metals in the environment. Proc 15th Hanford Life Sciences Symp, U.S. Energy Res Develop Admin, Washington, D.C., pp 240–253.Google Scholar
  109. Mankovska B, Arbetova D (1985) The accumulation of heavy metal in the tissues of birds—Larus ridibundus and Sterna hirundo. Biologia 40:557–561.Google Scholar
  110. Maruyama YU (1982) The effect on mice of long-term oral administration of trivalent and hexavalent chromium. Acta Scholae Medicinalis Universitatis in Gifu 31:24–46 (as cited in USPHS 1989).Google Scholar
  111. Mathur AK, Chandra SV, Tandon SK (1977) Comparative toxicity of trivalent and hexavalent chromium to rabbits. III. Morphological changes in some organs. Toxicology 8:53–61.PubMedCrossRefGoogle Scholar
  112. Matsumoto N, Iijima S, Katsunuma H (1976) Placental transfer of chromic chloride and its teratogenic potential in embryonic mice. J Toxicol Sci 2:1–13.CrossRefGoogle Scholar
  113. Merritt K, Crowe TD, Brown SA (1989) Elimination of nickel, cobalt, and chromium following repeated injections of high dose metal salts. J Biomed Mat Res 23:845–862.CrossRefGoogle Scholar
  114. Mertz W, Roginski EE, Reba RC (1965) Biological activity and fate of trace quantities of intravenous chromium(III) in the rat. Am J Physiol 209:489–494.PubMedGoogle Scholar
  115. Mertz W (1969) Chromium occurrence and function in biological systems. Physiol Rev 49:165–239.Google Scholar
  116. Mertz W (1979) Chromium—an overview. In: Shapcott D, Hubert J (eds) Chromium in nutrition and metabolism. Elsevier/North Holland Biomedical, Amsterdam, The Netherlands, pp 1–14.Google Scholar
  117. Mertz W (1982) Clinical and public health significance of chromium. In: Clinical, biochemical and nutritional aspects of trace elements. Alan R Liss, New York, pp 315–323.Google Scholar
  118. Mertz W (1983) Chromium: An ultra-trace element. Chem Sci 21:145–150.Google Scholar
  119. Mirsky N, Weiss A, Dori Z (1980) Chromium in biological systems. I. Some observations on glucose tolerance factor in yeast. J Inorg Biochem 13:11–21.PubMedCrossRefGoogle Scholar
  120. Morris RJ, Law RJ, Allchin CR, Kelly CA, Fileman CF (1989) Metals and organo-chlorines in dolphins and porpoises of Cardigan Bay, West Wales. Mar Pollut Bull 20:512–523.CrossRefGoogle Scholar
  121. Nakamuro K, Yoshikawa K, Saygato Y, Kurata H (1978) Comparative studies of chromosomal aberration and mutagenicity of trivalent and hexavalent chromium. Mutat Res 58:175–179.PubMedCrossRefGoogle Scholar
  122. NAS (National Academy of Sciences) (1974) Chromium. Washington, D.C., 155 pp.Google Scholar
  123. Nettesheim P, Hanna MG Jr, Doherty DG, Newell RF, Hellman A (1971) Effect of calcium Chromate dust, influenza virus, and 100 R whole-body X-radiation on lung tumour incidence in mice. J Natl Cancer Inst 47:1129–1144.PubMedGoogle Scholar
  124. Newbold RF, Amos J, Connell JR (1979) The cytotoxic, mutagenic and clastogenic effects of chromium-containing compounds on mammalian cells in culture. Mutât Res 67:55–63.PubMedGoogle Scholar
  125. NIOSH (National Institute for Occupational Health Safety) (1983) Registry of toxic effects of chemical substances, Vol 2. Washington, D.C., 72 pp.Google Scholar
  126. Norseth T, Alexander J, Aaseth J, Langard S (1982) Biliary excretion of chromium in the rat: A role of glutathione. Acta Pharmacol Toxicol 51:450–455.CrossRefGoogle Scholar
  127. NRCC (National Research Council of Canada) (1976) Effects of chromium in the Canadian environment. Rept No 15017, Ottawa, 139 pp.Google Scholar
  128. O’Brien P, Barrett J, Swanson F (1985) Chromium(V) can be generated in the reduction of chromium(VI) by glutathione. Inorg Chim Acta 135:115–118.Google Scholar
  129. Ogawa E (1976) Experimental study on absorption, distribution and excretion of trivalent and hexavalent chromium. Jap J Pharmacol 26:92 (summary only).CrossRefGoogle Scholar
  130. Onkelinx C (1977) Compartment analysis of metabolism of chromium(III) in rats of various ages. Am J Physiol 232:E478–E484.PubMedGoogle Scholar
  131. Outridge PM, Noller BN (1991) Accumulation of toxic trace elements by freshwater vascular plants. Rev Environ Contam Toxicol 121:1–63.CrossRefGoogle Scholar
  132. Parr RD, Taylor FG Jr (1980) Incorporation of chromium in vegetation through root uptake and foliar absorption pathways. Environ Exp Bot 20:157–160.CrossRefGoogle Scholar
  133. Polansky MM, Bryden NA, Anderson RA (1989) Chromium, copper, iron, manganese and zinc concentrations of tissues from turkey hens: Effects of egg production and supplemental chromium. Fed Am Soc Exp Biol J 3:A1072 (summary only).Google Scholar
  134. Powers WJ, Gad SC, Siino KM, Peckman JC (1986) Effects of therapeutic agents on chromium-induced acute nephrotoxicity. In: Serrone DM (ed) Chromium symposium 1986: An update. Industrial Hlth Foundation, Pittsburgh, Pa., pp. 79–86.Google Scholar
  135. Rai D, Eary LE, Zachara JM (1989) Enviromental chemistry of chromium. Sci Total Environ 86:15–23.PubMedCrossRefGoogle Scholar
  136. Reagor JC, McDonald D (1980) Chromate poisoning in cattle—a case report. Southwest Vet 33:10–11.Google Scholar
  137. Reichrtova E, Takac L, Kovacikova Z, Foltinova J, Bencko V, Kranerova J (1989) Bioaccumulation of metals from nickel smelter waste in P and Fl generations of exposed animals. I. Dynamics of metals distribution in the organs and AM activity. J Hyg Epidemiol Microbiol Immunol 33:1–10.PubMedGoogle Scholar
  138. Ridgway LP, Karnofsky DA (1952) The effects of metals on the chick embryo: Toxicity and production of abnormalities in development. Ann NY Acad Sci 55: 203–215.PubMedCrossRefGoogle Scholar
  139. Romoser GL, Dudley WA, Machlin LJ, Loveless L (1961) Toxicity of vanadium and chromium for the growing chick. Poult Sci 40:1171–1173.Google Scholar
  140. Rossi SC, Gorman N, Wetterhahn KE (1988) Mitochondrial reduction of the carcinogen Chromate: Formation of chromate(V). Chem Res Toxicol 1:101–107.PubMedCrossRefGoogle Scholar
  141. Saleh FY, Parkerton TF, Lewis RV, Huang JH, Dickson KL (1989) Kinetics of chromium transformations in the environment. Sci Total Environ 86:25–41.PubMedCrossRefGoogle Scholar
  142. Saner G (1980) Chromium in nutrition and disease. Current topics in nutrition and disease, Vol 2. Alan R Liss, New York, 129 pp.Google Scholar
  143. Saxena DK, Murthy RC, Jain VK, Chandra SV (1990) Fetoplacental-maternal uptake of hexavalent chromium administered orally in rats and mice. Bull Environ Contain Toxicol 45:430–435.CrossRefGoogle Scholar
  144. Sayato Y, Nakamuro K, Matoni S, Ando M (1980) Metabolic fate of chromium compounds. I. Comparative behavior of chromium in rat administered with Na2Cr04 and Cr03. J Pharmacol Dyn 3:17–23 (as cited in USPHS 1989).CrossRefGoogle Scholar
  145. Schroeder HA, Balassa JJ, Vinton WH Jr (1964) Chromium, lead, cadmium, nickel and titanium in mice: Effect on mortality, tumors and tissue levels. J Nutr 83: 239–250.PubMedGoogle Scholar
  146. Schroeder HA, Balassa JJ, Vinton WH Jr (1965) Chromium, cadmium, lead in rats: Effects on lifespan, tumors, and tissue levels. J Nutr 86:51–66.PubMedGoogle Scholar
  147. Seaborn CD, Stoecker BJ (1989) Effects of starch, sucrose, fructose and glucose on chromium absorptionand tissue concentrations in obese and lean mice. J Nutr 119:1444–1451.PubMedGoogle Scholar
  148. Shakhnazarov, AM (1973) Experimental histological investigation of pathomorphology of the myocardium in chronic chromium intoxication. Arch Pathol 35:67–73.Google Scholar
  149. Shi X, Dalai NS (1989) Chromium (V) and hydroxyl radical formation during the glutathione reductase-catalyzed reduction of chromium (VI). Biochem Biophys Res Comm 163:627–634.PubMedCrossRefGoogle Scholar
  150. Shiraishi Y, Ichikawa R (1972) Absorption and retention of chromium-51, nobium-95, cadmium-109 and tantalum-182 in newborn, juvenile and adult rats. J Rad Res 13:14 (abstract only).Google Scholar
  151. Skeffington RA, Shewry Pr, Peterson PJ (1976) Chromium uptake and transport in barley seedlings (Hordeum vulgare L.). Planta 132:209–214.CrossRefGoogle Scholar
  152. Smith S, Peterson PJ, Kwan KHM (1989) Chromium accumulation, transport and toxicity in plants. Toxicol Environ Chem 24:241–251.CrossRefGoogle Scholar
  153. Smyth HF, Carpenter CP, Weil CS, Pozzanni VC, et al. (1969) Range finding toxicity data: List VII. J Am Ind Hyg Assoc 30:470–498.Google Scholar
  154. Srivastava L, Jain VK, Kachru DN, Tandon SK (1985) Comparative toxicity of trivalent and hexavalent chromium. V: Enzymic alterations in rat liver and kidneys. Ind Hlth 23:89–94.CrossRefGoogle Scholar
  155. Starich GH, Blincoe C (1983) Dietary chromium—forms and availabilities. Sci Tot Environ 28:443–454.CrossRefGoogle Scholar
  156. Steffee CH, Baetjer AM (1965) Histopathologic effects of Chromate chemicals. Report of studies in rabbits, guinea pigs and mice. Arch Environ Hlth 11:66–76.Google Scholar
  157. Steinhoff D, Gad SC, Hatfield GK, Mohr U (1986) Carcinogenicity studies with sodium dichromate in animals. In: Serrone DM (ed) Chromium Symposium 1986: An update. Industrial Hlth Foundation, Pittsburgh, Pa., pp 131–155.Google Scholar
  158. Sutton JR, Farrell PA, Harber VJ (1990) Hormonal adaptation to physical activity. In: Bouchard C, Sheppard RJ, Stephens T, Sutton JR, McPherson BD (eds) Fitness, excercise, and health. Human Kinetics Books, Ill., pp 217–234.Google Scholar
  159. Taylor FG Jr, Parr PD (1978) Distribution of chromium in vegetation and small mammals adjacent to cooling towers. J Tenn Acad Sci 53:87–91.Google Scholar
  160. Toepfer EW, Mertz W, Roginski EE, Polansky MM (1973) Chromium in foods in relation to biological activity. J Agrie Food Chem 21:69–73.CrossRefGoogle Scholar
  161. USEPA (U.S. Environmental Protection Agency) (1988) Chromium. Rev Environ Contam Toxicol 107:39–52.Google Scholar
  162. USPHS (U.S. Public Health Service) (1989) Toxicological profile for chromium. Agency for Toxic Substances and Disease Registry, ATSDR/TP-88/10, Atlanta, Ga., 135 pp.Google Scholar
  163. Wahlberg JE, Skog E (1965) Percutaneous absorption of trivalent and hexavalent chromium. Arch Dermatol Res 92:315–318.CrossRefGoogle Scholar
  164. Warren G, Schultz P, Bancroft D, Bennett K, Abbott EH, Rogers S (1981) Mutagenicity of a series of hexacoordinate chromium(III) compounds. Mutat Res 90: 111–118.PubMedCrossRefGoogle Scholar
  165. Wetterhahn KE, Cupo DY, Connett PH (1984) Metal carcinogens: Metabolism and interaction with proteins and DNA In: Hemphill DD (ed) Trace substances in environmental health XVIII Univ of Missouri, Columbia, pp 154–162.Google Scholar
  166. White DH, King KA, Prouty RM (1980) Significance of organochlorine and heavy metal residues in wintering shorebirds at Corpus Christi, Texas, 1976–77. Pestic Monit J 14:58–63.PubMedGoogle Scholar
  167. Wiegand HJ, Ottenwaelder H, Bolt HM (1984) The reduction of chromium(VI) to chromium(III) by glutathione: An intracellular redox pathway in the metabolism of the carcinogen Chromate. Toxicology 33:341–348.PubMedCrossRefGoogle Scholar
  168. Wiegand HJ, Ottenwaelder H, Bolt HM (1987) Bioavailability and metabolism of hexavalent chromium compounds. Toxicol Environ Chem 14:163–275.CrossRefGoogle Scholar
  169. Wiemeyer SN, Lamont TG, Locke LN (1980) Residues of environmental pollutants and necroscopy data for eastern United States ospreys, 1964–1973. Estuaries 3: 155–167.CrossRefGoogle Scholar
  170. Wiemeyer SN, Schmeling SK, Anderson A (1987) Environmental pollutant and necroscopy data for ospreys from the eastern United States, 1975–1982. J Wildlife Dis 23:279–291.Google Scholar
  171. Witmer CM, Park H-S, Shupack SI (1989) Mutagenicity and disposition of chromium. Sci Total Environ 86:131–148.PubMedCrossRefGoogle Scholar
  172. Woodyard DK, Campa H III, Haufler JB (1986) The influence of forest application of sewage sludge on the concentrations of metals in vegetation and small mammals. In: Cole DW, Henry CL, Nutter WL (eds) The forest alternative for treatment and utilization of municipal and industrial wastes. Univ Wash Press, Seattle, pp 213–218.Google Scholar
  173. Yamaguchi S, Sano K, Shimojo N (1983) On the biological half-time of hexavalent chromium in rats. Ind Hlth 21:25–34.CrossRefGoogle Scholar
  174. Yoshikawa H (1970) Preventive effect of pretreatment with low dose of metals on the acute toxicity of metals in mice. Ind Hlth 8:184–191.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1993

Authors and Affiliations

  1. 1.Department of ZoologyUniversity of TorontoTorontoCanada
  2. 2.Canadian Wildlife ServiceEnvironment CanadaHullCanada

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