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Aflatoxins in Animal and Human Health

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Reviews of Environmental Contamination and Toxicology

Part of the book series: Reviews of Environmental Contamination and Toxicology ((RECT,volume 127))

Abstract

Although aflatoxins have been the cause of numerous deaths in livestock and suspected in some deaths of humans, the impact of aflatoxin consumption by a wide variety of animal species, including humans, extends much further than such a focal point. The economic significance of this group of toxins occurring in feeds and foods is through lowered productivity including meat and eggs, reduced weight gain, reduced feed efficiency, increased incidence of disease because of immunosuppression, and subtle damage to vital organs. Several human diseases have been recognized as being caused by aflatoxins, especially acute aflatoxicosis associated with highly contaminated foodstuffs (Shank 1977; Krishnamachari et al. 1975a, 1975b; Ngindu et al. 1982).

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References

  • Adamson RH, Correa P, Dalgaard DW (1973) Brief communication: Occurrence of a primary liver carcinoma in a Rhesus monkey fed aflatoxin Bj. J Natl Cancer Inst 50: 549–553

    PubMed  CAS  Google Scholar 

  • Adinarayanaiah GL, Nanjiah RD, Keshavamurthy BS (1973) Effect of aflatoxin on antibody production to Salmonella pullorum antigen in chicks. Indian Vet J 2: 297.

    Google Scholar 

  • Allcroft R (1965) Aspects of aflatoxicosis in farm animals. In: Wogan GN (ed) Mycotoxins in Foodstuffs: Proceedings of MIT Symposium, March 18–19, 1964. Cambridge, MA, pp 153–162.

    Google Scholar 

  • Alpert ME, Hütt MSR, Davidson CS (1969) Primary hepatoma in Uganda, a prospective clinical and epidemiological study in 46 patients. Am J Med 46:794– 802.

    Article  PubMed  CAS  Google Scholar 

  • Applebaum RS, Brackett RE, Wiseman DW, Marth EH (1982) Responses of dairy cows to dietary aflatoxin: Feed intake and yield, toxin content, and quality of milk of cows treated with pure and impure aflatoxin. J Dairy Sci 65: 1503–1508.

    Article  PubMed  CAS  Google Scholar 

  • Armbrecht BH, Wiseman HG, Shalkop WT (1972) Swine aflatoxicosis II. The chronic response in brood saws fed sublethal amounts of aflatoxin and the reaction in their piglets. Environ Phys Biochem 2: 77–85.

    CAS  Google Scholar 

  • Asao T, Buche G, Abdel Kader MM, Chang SB, Wick EL, Wogan GN (1965) The structures of Aflatoxin B1 and G1. In: Wogan GH (ed) Mycotoxins in Foodstuffs: Proceedings of MIT Symposium, March 18–19, 1964. MIT Press, Cambridge, MA, pp 265–273.

    Google Scholar 

  • Autrup H, Bradley KA, Shamsuddin AKM, Wakhisi J, Wasunna A (1983) Detection of putative adduct with fluorescence characteristics identical to 2,3-dihydro-2(7- N-guany1)-3-hydroxy-aflatoxin B1 in human urine in Murang’s District, Kenya. Carcinogenesis 9: 1193–1195.

    Article  Google Scholar 

  • Autrup H, Seremet T, Wakhisi J, Wasunna A (1987) Aflatoxin exposure measured by urinary excretion of aflatoxin B j guanine adduct and hepatitis B virus infection in areas with different liver cancer incidence in Kenya. Cancer Res 47: 3420.

    Google Scholar 

  • Baertschi SW, Raney KD, Stone MP, Harris TM (1988) Preparation of 8,9 epoxide of the mycotoxin aflatoxin, Bls the ultimate carcinogenic species. J Am Chem Soc 110: 7929–7931.

    Article  CAS  Google Scholar 

  • Bassendine MF (1987) Aetiological factors in heptocellular cancer. Bailliere’s Clin Gastroenterol 1 (1): 1–16.

    Article  PubMed  CAS  Google Scholar 

  • Blount WP (1960) A new turkey disease problem in England. Brit Oil and Cake Mills, Ltd. Quar Poult Bull 27: 1–3.

    Google Scholar 

  • Blount WP (1961) Turkey “X” disease. Turkeys 9:2:52, 55, 58, 61, 77.

    Google Scholar 

  • Bodine AB, Mertens DR (1983) Toxicology, metabolism, and physiological effects of aflatoxins in the bovine. In: Diener UL, Asquith RL, Dickens JW (eds) Aflatoxin and Aspergillus flavus in corn. Alabama Agric Exp Sta, Auburn Univ, AL, pp 46–50.

    Google Scholar 

  • Boonchuvit B, Hamilton PB, Burneister HR (1975) Interaction of Tz toxin w/salmonella infections in chickens. Poult Sci 54: 1693–1696.

    PubMed  CAS  Google Scholar 

  • Bressac B, Kew M, Wands J, Ozturk M (April 1991) Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature 350:429– 430.

    Article  PubMed  CAS  Google Scholar 

  • Brown RW, Pier AC, Richard JL, Krogstad RE (1981) Effects of dietary aflatoxin on existing bacterial intramammary infections in dairy cattle. Am J Vet Res 42:927– 933

    PubMed  CAS  Google Scholar 

  • Burg WR, Shotwell OL, Saltzman BE (1981) Measurements of airborne aflatoxins during the handling of contaminated corn. Am Ind Hyg Assoc J 42: 1–11.

    Article  PubMed  CAS  Google Scholar 

  • Burg WR, Shotwell OL, Saltzman BE (1982) Measurements of airborne aflatoxins during the handling of 1979 contaminated corn. Am Ind Hyg Assoc J 43:580– 586.

    Article  CAS  Google Scholar 

  • Burg WR, Shotwell OL (1984) Aflatoxin levels in airborne dust generated from contaminated corn during harvest and at an elevator in 1980. J Assoc Offic Anal Chem 67: 2: 309–312.

    CAS  Google Scholar 

  • Busby WF Jr, Wogan GN (1981) Aflatoxins. In: Shank RC (ed) Mycotoxins and N-Nitroso Compounds. CRC Press, Boca Raton, FL, pp 3–27.

    Google Scholar 

  • Butler WH, (1965) Liver Injury and Aflatoxin. In: Wogan GH (ed) Mycotoxins in Foodstuffs, Proceedings of MIT Symposium, March 18–19, 1964, MIT Press, Cambridge, MA, pp 175–186.

    Google Scholar 

  • Byong IY, Rothenbacker H (1982) Immunopathologic effects of aflatoxin on lymphoid tissues and on the pathogenesis of Newcastle disease. J Am Vet Med Assoc 181: 286 (abstract)

    Google Scholar 

  • Campbell ML Jr, May JD, Huff WE, Doerr JA (1983) Evaluation of immunity of young broiler chickens during simultaneous aflatoxicosis and orhratoxicosis. Poult Sci 62: 2138–2144.

    PubMed  CAS  Google Scholar 

  • Campbell TC, Caedo JP, Bullatto JJ, Salamet L, Engel RW (1970) Aflatoxin Ml in human urine. Nature (London) 227: 403–404.

    Article  CAS  Google Scholar 

  • Campbell TC, Stoloff L (1974) Implication of mycotoxins for human health. J Agr Food Chem 22 (6): 1006–1015.

    Article  CAS  Google Scholar 

  • Campbell TC, Chen J, Liu C, Li J, Parpia B (1990) Nonassociation of aflatoxin with primary liver cancer in a cross-sectional ecological survey in the People’s Republic of China, Cancer Res 50: 6882–6893.

    PubMed  CAS  Google Scholar 

  • Carnaghan RBA (1965) Hepatic tumors in ducks fed a low level of toxic groundnut meal. Nature 203: 308.

    Article  Google Scholar 

  • CAST (1989) Mycotoxin, Economic and Health Risks. Task Force Rept 116.

    Google Scholar 

  • Caster, WO, Burton, TA, Irvin TR, Tanner MA (1986) Dietary aflatoxins, intelligence and school performance in Southern Georgia. Int J Vit Nutr Res 56:291– 295.

    CAS  Google Scholar 

  • Cheng-ya W, Xin-sheng Y, Jin-Xin H, Tao-zhen L, Yao-qin Y (1987) HLA related genetic control of natural killer activity and aflatoxin B1 suppression of lymphocytic blastogenesis. Chin Med J Engl 100: 29–33.

    Google Scholar 

  • Cole RJ (1986) Etiology of turkey “X” disease in retrospect: A case for the involvement of cyclopiazonic acid. Mycotoxin Res 2: 3–7.

    Article  Google Scholar 

  • Cook WO, Richard JL, Osweiler GD, Trampel DW (1986) Clinical and pathologic changes in acute bovine aflatoxicosis: Rumen motility and tissue and fluid concentrations of aflatoxin B1 and M,. Am J Vet Res 47: 1817–1825.

    PubMed  CAS  Google Scholar 

  • Cook WO, Van Alstine WG, Osweiler GD (1989) Aflatoxins in Iowa swine: Eight cases (1983–1985) JAVMA 194: 554–558.

    PubMed  CAS  Google Scholar 

  • Cysewski SJ, Pier AC, Engstrom GW, Richard JL, Dougherty RW, Thurston JR (1968) Chemical pathologic features of acute aflatoxicosis of swine. Am J Vet Res 29: 1577–1590.

    PubMed  CAS  Google Scholar 

  • Cysewski SJ, Wood RL, Pick AC, Baetz AL (1978) Effects of aflatoxin on the development of acquired immunity to swine erysipelas. Am J Vet Res 39:445–448.

    PubMed  CAS  Google Scholar 

  • Dalvi RR (1986) An overview of aflatoxicosis of poultry: Its characteristics, prevention and reduction. Vet Res Comm 10: 429–443.

    Article  CAS  Google Scholar 

  • Deger GE (1976) Aflatoxin—Human colon carcinogenesis? Ann Intern Med 85: 204.

    PubMed  CAS  Google Scholar 

  • Dietert RR, Qureshi MA, Nanna UC, Bloom SE (1985) Embryonic exposure to aflatoxin Bx: Mutagenicity and influence on development and immunity. Environ Mut 7: 715–725.

    Article  CAS  Google Scholar 

  • Doerr JA, Huff WE, Hamilton PB (1987) Increased sensitivity to staphylococcal beta hemolysins of erythrocytes from chickens during aflatoxicosis. Poult Sci 66: 1929–1933.

    PubMed  CAS  Google Scholar 

  • Duthie IF, Lancaster MC, Taylor J, Thomas DC, Shacklady CA, Attfield PH, Fuller- Lewis E (1966) Toxic groundnut meal in feeds for pig. I. A trial made at 2 laboratories with pigs from about 40–200 pounds live weight fed to a restricted scale. Vet Ree 79: 621–625.

    Article  CAS  Google Scholar 

  • Dvorackova I, Stora C, Ayraud N (1981) Evidence for aflatoxin B1 in two cases of lung cancer in man. Cancer Res Clin Oncol 100: 221–224.

    Article  CAS  Google Scholar 

  • Dvorak R, Jagos J, Bouda J, Piskac A, Zapletal O (1977) Changes in the clinico- biochemical indices in the rumen liquor and urine in cases of experimental aflatoxicosis in dairy cows. Vet Med (Prague) 22: 161–169.

    CAS  Google Scholar 

  • Edds GT, Nair KPC, Simpson CF (1973) Effect of aflatoxin B! on resistance in poultry against cecal coccidiosis and Marek’s disease. Am J Vet Res 34:819–826.

    PubMed  CAS  Google Scholar 

  • Essigmann JM, Croy RG, Nadzan AM, Busby WF Jr, Reinhold VN, Biechi G, Wogan GN (1977) Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro. Proc Nat Acad Sei USA 74: 1870–1874.

    Article  CAS  Google Scholar 

  • Fehr PM, Delage J (1970) Effect de l’aflatoxine sur les fermentations du rumen. Can Nutr Diet 5: 59–61.

    Google Scholar 

  • Galikeev KHL, Raipov OR, Manyasheva RA (1968) Effect of aflatoxin on dynamics of antibody formation. Byul Eksper Biol Medoc (USSR) 65: 88 (translation).

    Google Scholar 

  • Garlich JD, Tung HT, Hamilton PB (1973) The effects of short term feeding of aflatoxin on egg production and some plasma constituents of the laying hen. Poult Sci 52: 2206–2211.

    PubMed  CAS  Google Scholar 

  • Garner C, Ryder R, Montesano R (1985) Monitoring of aflatoxins in human body fluids and application to field studies. Cancer Res 45: 922–928.

    Google Scholar 

  • Giambrone JJ, Ewert DL, Wyatt RD, Edison CS (1978) Effect of aflatoxin on the humoral and cell mediated immune systems of the chicken. Am J Vet Res 39:305–308.

    PubMed  CAS  Google Scholar 

  • Goldblatt LA (ed) (1969) Aflatoxin Scientific Background Control and Implications. Academic Press, New York.

    Google Scholar 

  • Gopalakrishnan S, Harris TM, Stone MP (1990) Intercalation of aflatoxin B in two oligudeoxynurleotide adducts: Comparative H NMR analysis of d (ATC AFB GAT), d (ATCGAT) and d (AT AFBGCAT)2. Biochemistry 29: 10438–10448.

    Article  PubMed  CAS  Google Scholar 

  • Groopman JD, Cain LG, Kensler TW (1988) Aflatoxin exposure in human populations: Measurements and relationship to cancer. CRC Crit Rev Toxicol 19: 113–145.

    Article  CAS  Google Scholar 

  • Groopman JD, Donohue K (1988) Aflatoxin, a human carcinogen: Determination in foods and biological samples by monoclonal antibody affinity chromatography. J Assoc Anal Chem 71: 5: 861–867.

    CAS  Google Scholar 

  • Groopman JD, Sabbioni G (1991) Detection of aflatoxin and its metabolites in human biological fluids. In: Bray GA, Ryan DH (eds) Mycotoxins, Cancer, and Health. Louisiana State Univ. Press, Baton Rouge, LA, pp 18–31.

    Google Scholar 

  • Guthrie LD (1979) Effects of aflatoxin in corn on production and reproduction in dairy cattle. J Dairy Sci 62: 134.

    Google Scholar 

  • Halver JE (1969) Aflatoxicans and trout hepatoma. In: Goldblatt LA (ed) Aflatoxin. Academic Press, New York, pp 265–306.

    Google Scholar 

  • Hamilton PB (1971) A natural and extremely severe occurrence of aflatoxicosis in laying hens. Poult Sci 50: 1880–1882.

    PubMed  CAS  Google Scholar 

  • Hamilton PB, Garlich JD (1971) Aflatoxin as a possible cause of fatty liver syndrome in laying hens. Poult Sci 50: 800–804.

    PubMed  CAS  Google Scholar 

  • Hamilton PB, Harris JR (1971) Interaction of aflatoxins with Candida albican infections and other stresses in chicken. Poult Sci 50: 906–912.

    PubMed  CAS  Google Scholar 

  • Harris AL (April 1991) Telling changes of base. Nature 350: 377–378.

    Article  PubMed  CAS  Google Scholar 

  • Hartley RD, Nesbitt BF, O’Kelley J (1963) Toxic metabolites of Aspergillus flavus. Nature 198: 1056–1058.

    Article  CAS  Google Scholar 

  • Hayes RB, Van Nieuwenhuize JP, Raatgever JW, ten Kate FJW (1984) Aflatoxin exposures in the industrial setting: An epidemiological study of mortality. Food Chem Toxicol 22: 1: 39–43.

    Article  PubMed  CAS  Google Scholar 

  • Hendrickse RG, Coulter JBS, Lamplugh SM, MacFarlane SBJ, Williams TE, Omer MIA, Sulimen GI, El-Zorgani GA (1983) Aflatoxins and kwashiorkor: Epidemiology and clinical studies in Sudanese children and findings in autopsy liver samples from Nigeria and South Africa. Bull Soc Pathol Exp 76: 559–566.

    CAS  Google Scholar 

  • Hendrickse RG (1984) Kwashiorkor: 50 years of myth and mystery. Do aflatoxins provide a clue? Acta Leidensia 53: 11–30.

    Google Scholar 

  • Hendrickse RG (1985) The influence of aflatoxins on child health in the tropics with particular reference to kwashiorkor. Trans Royal Soc Trop Med Hyg 78:427–435.

    Article  Google Scholar 

  • Hintz HF, Heitman HJ, Booth AN, Gagne WE (1967) Effects of aflatoxin on reproduction in swine. Proc Soc Exp Biol Med 126: 146–148.

    PubMed  CAS  Google Scholar 

  • Hsu IC, Metealf RA, Sun T, Welsh JA, Wang NJ, Harris CC (April 1991) Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature 350:427–428.

    Article  PubMed  CAS  Google Scholar 

  • Huff WE, Doerr JA (1981) Synergisn between aflatoxin and ochratoxin A in broiler chickens. Poult Sci 60: 550–555.

    PubMed  CAS  Google Scholar 

  • Huff WE, Doerr JA, Wabeck CJ, Chaloupka GW, May JD, Merkley JW (1983) Individual and combined effects of aflatoxin and ochratoxin A on bruising in broiler chickens. Poult Sci 62: 1764–1771.

    PubMed  CAS  Google Scholar 

  • Huff WE, Kubena LF, Harvey RB, Hagler WM, Jr, Swanson SP, Phillips TD, Creger CR (1986) Individual and combined effects of aflatoxin and deoxynivalenol ( DON, vomitoxin) in broiler chickens. Poult Sci 65: 1291–1298.

    PubMed  CAS  Google Scholar 

  • Huff WE, Harvey RB, Kubena LF, Rottinghaus GE (1988) Toxic synergism between aflatoxin and T-2 toxic in broiler chickens. Poult Sci 67: 1418–1423.

    PubMed  CAS  Google Scholar 

  • International Agency for Research in Cancer (IARC) (1976) Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man: Some Naturally Occurring Substances, Vol 10. Lyon, France, pp 51–72.

    Google Scholar 

  • IARC (1987) Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans: Aflatoxins, Suppl 7. Lyon, France, pp 83–87.

    Google Scholar 

  • Joens LA, Pier AC, Cutlip R (1981) Effects of aflatoxin consumption on the clinical course of swine dysentery. Am J Vet Res 42: 1170–1172.

    PubMed  CAS  Google Scholar 

  • Kratzer FH, Bandy D, Wiley M, Booth AN (1968) Aflatoxin effects in poultry. Proc Soc Exp Biol Med 131: 1281–1284.

    Google Scholar 

  • Kraybill HF, Shimkin MB (1964) Carcinogenesis related to foods contaminated by processing and fungal metabolites. Adv Cancer Res 8: 191–248.

    Article  PubMed  CAS  Google Scholar 

  • Krishnamachari, KAVR, Bhat, RV, Nagarajan, V, Tilac, TBG (1975a) Investigations into an outbreak of hepatitis in Western India. Ind J Med Res 63: 1036–1048.

    CAS  Google Scholar 

  • Krishnamachari, KAVR, Bhat, RV, Nagarajan, V, Tilac, TBG (1975b) Hepatitis due to aflatoxicosis. Lancet 1: 1061–1063.

    Article  PubMed  CAS  Google Scholar 

  • Lancaster MC, Jenkins FP, Philp JM (1961) Toxicity associated with certain samples of groundnuts. Nature (London) 192: 1095–1096.

    Article  Google Scholar 

  • Lancaster MC (1968) Comparative aspects of aflatoxin-induced hepatic tumors. Cancer Res 28: 2288–2292.

    PubMed  CAS  Google Scholar 

  • Larsen AB, Cysewski SL, Miller JM (1975) Effects of aflatoxin on susceptibility of hamsters to mycobacterium paratuberculosis. Am J Vet Res 36: 1545–1547.

    PubMed  CAS  Google Scholar 

  • Masri MS, Garcia VC, Page JR (1969) The aflatoxin M1 content of milk from cows fed known amounts of aflatoxin. Vet Ree 84: 146–147.

    Article  CAS  Google Scholar 

  • McLoughlin ME, Pier AC, Thurston JR (1984) Use of bacteria and yeasts to identify T lymphocytes in peripheral blood and lymphoid tissues of healthy guinea pigs fed aflatoxin. Am J Vet Res 45: 1795–1799.

    PubMed  CAS  Google Scholar 

  • Mertens DR (1979) Biological effects of mycotoxins upon rumen function and lactating dairy cows. In: Proceedings of Symposium on Interaction of Mycotoxins in Animal Production, Michigan State Univ, Lansing, July 13, 1978. Natl Acad Sci, Washington, DC, pp 118–136.

    Google Scholar 

  • Michael GY, Thaxton P, Hamilton PB (1973) Impairment of the reticuloendothelial system of chickens during aflatoxicosis. Poult Sci 52: 1206–1207.

    PubMed  CAS  Google Scholar 

  • Miller DM, Stuart BP, Crowell WA (1981) Experimental aflatoxicosis in swine. Morphological and clinical pathological results. Can J Corp Med 45: 343–351.

    CAS  Google Scholar 

  • Miller DM, Crowell WA, Stuart BP (1982) Acute aflatoxicosis in swine: Clinical pathology, histopathology, and electron microscopy. Am J Vet Res 43: 273–277.

    PubMed  CAS  Google Scholar 

  • Ngindu A, Kenya PR, Ocheng DM, Omonde TN, Ngare W, Gatei D, Johnson BK, Ngira, JA, Nandwa, H, Jansen, AJ, Kaviti, JN, Siongok, TA (1982) Outbreak of acute hepatitis caused by aflatoxin poisoning in Kenya. Lancet 1: 1346–1348.

    Article  PubMed  CAS  Google Scholar 

  • Oettle AG (1965) The etiology of primary carcinoma of the liver in Africa: A critical appraisal of previous ideas with an outline of the mycotoxin hypothesis. S. A. Tydskrif Vir Geneeskunde 9 October: 817–825.

    Google Scholar 

  • Panangala VS, Giambrone JJ, Diener UL, Davis ND, Hoerr FJ, Mitra A, Schultz RD, Wilt GR (1986) Effects of aflatoxin on the growth performance and immune responses of weanling swine. Am J Vet Res 47: 2062–2067.

    PubMed  CAS  Google Scholar 

  • Park DL, Pohland AE (1986) A rationale for the control of aflatoxin in animal feeds. In: Steyn PS, Vleggaar R (eds) Mycotoxins and Phycotoxins. Presented at the 6th International IUP AC Symposium on Mycotoxins and Phycotoxins, Pretoria, Republic of South Africa, July 22–25, 1985. Elsevier Scientific Pub, Amsterdam, The Netherlands, pp 473–482.

    Google Scholar 

  • Patterson DSP, Anderson PH (1982) Recent aflatoxin feeding experiments in cattle. Vet Ree 110: 60.

    Article  CAS  Google Scholar 

  • Peers FG, Linsell CA (1973) Dietary aflatoxins and liver cancer—a population study in Kenya. Brit J Cancer 27: 473–484.

    Article  PubMed  CAS  Google Scholar 

  • Peers FG, Gilman CA, Linsell CA (1976) Dietary aflatoxins and human liver cancer— a study in Swaziland. Int J Cancer 17: 167–176.

    Article  PubMed  CAS  Google Scholar 

  • Peers F, Bosch X, Kaldor J, Linsell A, Pluijmen M (1987) Aflatoxin exposure, hepatitis B virus infection and liver cancer in Swaziland. Int J Cancer 39:545– 553.

    Article  PubMed  CAS  Google Scholar 

  • Pier AC, Heddleston KL (1970) The effect of aflatoxin on immunity on turkeys. I. Impairment of actively acquired resistance to bacterial challenge. Avian Dis 14: 797–809.

    Article  PubMed  CAS  Google Scholar 

  • Pier AC, Heddleston KL, Boney WA, Lukert PD (1971) The effect of aflatoxin on immunity. Proc XIX Cong Mundial de Med Vet Zootech 1: 216–219.

    Google Scholar 

  • Pier AC, Cysewski SJ, Richard JL, Baetz AL, Mitchell L (1976) Experimental mycotoxosis in calves with aflatoxin, ochratoxin, rubratoxin, and T-2 toxin. In: Proceedings 80th Annual Meeting of US Animal Health Association, pp 130–148.

    Google Scholar 

  • Pier AC (1981a) Mycotoxins and animal health. Adv Vet Sci Comp Med 25:185– 243.

    PubMed  CAS  Google Scholar 

  • Pier, AC (1981b) Mycotoxins and animal health. Adv Vet Sci Comp Med 25:185– 243.

    PubMed  CAS  Google Scholar 

  • Pier AC, McLoughlin ME, Richard JL, Baetz A, Dahlgren RR (1985) In utero transfer of aflatoxin and selected effects in neonatal pigs. In: Lacey J (ed) Trichothecenes and Other Mycotoxins. Wiley, New York, pp 495–506.

    Google Scholar 

  • Pier AC, McLoughlin ME (1985) Mycotoxic suppression of immunity. In: Lacey J (ed) Trichothecenes and Other Mycotoxins. Wiley, New York, pp 507–519.

    Google Scholar 

  • Pier AC (1986) Immunimodulation in aflatoxicosis. In: Richard JL, Thurston JR (eds) Diagnosis of Mycotoxicoses. Martinus Nijhoff Pub, Dordrecht; pp 143–148.

    Chapter  Google Scholar 

  • Price RL, Paulson JH, Lough OG, Gingg C, Kurtz AG (1984) Aflatoxin conversion by dairy cattle consuming naturally contaminated whole cottonseed. Bull Dept Nutr Food Sei Univ Arizona, Tucson, AZ.

    Google Scholar 

  • Ratanesthankful C (1983) Effect of alflatoxin on immune response to Australian infectious bronchitis virus in chickens. Ph.D. diss, Univ. Sydney, Australia.

    Google Scholar 

  • Reddy RV, Taylor MJ, Sharma RP (1987) Studies of immune function of CD-I mice exposed to aflatoxin Bj. Toxicol 43: 123–132.

    Article  CAS  Google Scholar 

  • Reye RDK, Morgan G, Baral J (1963) Encephalopathy and fatty degeneration of the viscera: A disease entity in childhood. Lancet 2: 749–752.

    Article  PubMed  CAS  Google Scholar 

  • Richard JL, Pier AC, Cysewski SJ, Grehan CK (1973) Effect of aflatoxin and aspergillosis on turkey poults. Avian Dis 17: 111–121.

    Article  PubMed  CAS  Google Scholar 

  • Richard JL, Thurston JR (1975) Effect of aflatoxin on phagocytosis of Aspergillus fumigatus spores by rabbit alveolar macrophages. Appl Mircobiol 30: 44–77.

    CAS  Google Scholar 

  • Richard JL, Thurston JR, Pier AC (1978) Effects of mycotoxins on immunity. In: Rosenberg P (ed) Toxins: Animal, Plant, and Microbial. Pergamon Press, New York, pp 801–817.

    Google Scholar 

  • Richard JL, Pier AC, Stubblefield RD, Shotwell OL, Lyon RL, Cutlip RC (1983) Effect of feeding corn naturally contaminated with aflatoxin on feed efficiency, on physiologic, immunologic, and pathologic changes, and on tissue residue in steers. Am J Vet Res 44: 1294–1299.

    PubMed  CAS  Google Scholar 

  • Richard JL, Stubblefield RD, Lyon RL, Peden WM, Thurston JR, Rimler RB (1986) Distribution and clearance of aflatoxins Bj and Mj in turkeys fed diets containing 50 or 150 ppb aflatoxins from naturally contaminated corn. Avian Dis 30: 788–793.

    Article  PubMed  CAS  Google Scholar 

  • Richard JL (1991) Mycotoxins as immunomodulators in animal systems. In: Bray GA, Ryan DH (eds) Mycotoxins, Cancer, and Health. Pennington Nutrition Series, Louisiana State Univ Press, Baton Rouge, LA, pp 197–220.

    Google Scholar 

  • Rogan WJ, Yang GC, Kimbrough RD (1985) Aflatoxin and Reye’s syndrome: A study of livers from diseases cases. Arch Environ Hlth 40: 2: 91–95.

    CAS  Google Scholar 

  • Ryan NJ, Hogan GR, Hayes AW, Unger PD, Siraj MY (1979) Aflatoxin Bl: Its role in the etiology of Reye’s syndrome. Pediatrics 64 (1): 71–75.

    PubMed  CAS  Google Scholar 

  • Sabbioni G, Skipper PL, Buchi G, Tannenbaum SR (1987) Isolation and characterization of the major serum albumin adduct formed by aflatoxin Bj in vivo in rats. Carcinogenesis 8 (6): 819–824.

    Article  PubMed  CAS  Google Scholar 

  • Sargeant K, Shendan A, O’Kelly J, Carnahan RBA (1961) Toxicity associated with certain samples of groundnuts. Nature 192: 1096–1097.

    Article  Google Scholar 

  • Shalkop WT, Armbrecht BH (1974) Carcinogenic response of brood sows fed aflatoxin for 28 to 30 months. Am J Vet Res 35: 623–627.

    PubMed  CAS  Google Scholar 

  • Shank RC, Gordon JE, Wogan GN (1972) Dietary aflatoxins and human liver cancer. III. Field survey of rural Thai families for ingested aflatoxins. IV. Incidence of primary liver cancer in two municipal populations of Thailand. Food Cosmet Toxicol 10:71–84, 171–179.

    Article  PubMed  CAS  Google Scholar 

  • Shank RC (1977) Epidemiology of aflatoxin carcinogenesis. Adv Mod Toxicol 3:291–318.

    Google Scholar 

  • Sherlock S, Fox RA, Scheuer PJ (1970) Chronic liver disease and primary liver-cell cancer with hepatitis-associated ( Australia) antigen in serum. Lancet 1: 1243–1247.

    Article  PubMed  CAS  Google Scholar 

  • Shimada T, Guengrich FP (1989) Evidence for cytochrome P-450-N-F the nifedipine oxidase being the principal enzyme involved in the bioactivation of aflatoxins in human liver. Proc Natl Acad Sci 86: 462–465.

    Article  PubMed  CAS  Google Scholar 

  • Silas JC, Harrison MA, Carpenter JA, Roth IL (1987) Airborne aflatoxin in corn processing facilities in Georgia. Am Ind Hyg Assoc J 48 (3): 198–201.

    Article  PubMed  CAS  Google Scholar 

  • Sisk DB, Carlton WW (1972) Effect of dietary protein concentration on response. Am J Vet Res 33: 107–114.

    PubMed  CAS  Google Scholar 

  • Smith JW, Prince WR, Hamilton PB (1969) Relationship of aflatoxins to Salmonella gallinorum infections of chickens. Appl Microbiol 18 (5): 946–947.

    PubMed  CAS  Google Scholar 

  • Southern LL, Clawson AJ (1979) Effects of aflatoxins on finishing swine. J An Sci 49: 1006–1011.

    CAS  Google Scholar 

  • Stoloff L (1977) Aflatoxins—An overview. In: Mycotoxins in Human and Animal Health. Rodrick, Hesseltine and Mehlman, Pathotox, pp 7–8.

    Google Scholar 

  • Stoloff L (1983) Aflatoxin as a cause of primary liver-cell cancer in the United States: A probability study. Nutr Cancer 5:3–4, 165–185.

    Article  PubMed  CAS  Google Scholar 

  • Sun T-T, Chu Y-Y (1984) Carcinogenesis and prevention strategy of liver cancer in areas of prevalence. J Cell Physiol 3 (Suppl.): 39–44.

    Google Scholar 

  • Sun TT, Wu SM, Wu YY, Chu YR (1986) Measurement of individual aflatoxin exposure among people having different risk to primary hepatocellular carcinoma. In: Hayashi Y et al. (eds), Diet, Nutrition and Cancer. Japan Sci Soc Press, Tokyo/VNU Sci Press, Utrecht, pp 225–235.

    Google Scholar 

  • Thaxton JP, Tung HT, Hamilton PB (1974) Immunosuppression in chickens by aflatoxin. Poult Sci 53: 721.

    PubMed  CAS  Google Scholar 

  • Thurston JR, Richard JL, Cysewski SJ, Pier AC, Graham CK (1972) Effect of aflatoxin on complement activity in guinea pigs. Proc Soc Exp Biol Med 138: 300–303.

    Google Scholar 

  • Thurston JR, Deyoe BL, Baetz AL, Richard JL, Booth GD (1974) Effect of aflatoxin on serum proteins, complement activity, and the antibody response to Brucella abortus in guinea pigs. Am J Vet Res 35: 1097.

    PubMed  CAS  Google Scholar 

  • Thurston JR, Cook W, Driftmier K, Richard JL (1986). Decreased complement and bacteriostatic activities in the sera of cattle given single or multiple doses of aflatoxin. Am J Vet Res 47: 836–849.

    Google Scholar 

  • Trucksess MW, Richard JL, Stoloff L, McDonald JS, Brumby WC (1983) Absorptions and distribution patterns of aflatoxical and aflatoxins Bj and Mj in blood and milk of cows given aflatoxin B,. Am J Vet Res 44: 1753–1756.

    PubMed  CAS  Google Scholar 

  • Van Dijk HJ, O’Dell GD, Bodine AB (1984) Effects of aflatoxin M! intake, its physiologic levels on newborn dairy calves. Am J Vet Res 45: 1994–1997.

    PubMed  Google Scholar 

  • Van Nieuwenhuize JP, Herber RFM, de Bruin A, Meyer PB, Duba WC (1973) Aflatoxinen: Epidemiologisch onderzoek naar carcinogeniteit bij langdurige “low level” expositie van een fabriekspopulatie. T. Soc Geneesk 51: 754.

    Google Scholar 

  • Van Rensburg SJ, Van Der Watt JJ, Purchase IFH, Pereira Coutinho L, Markham L (1974) Primary liver cancer rate and aflatoxin intake in a high cancer area. S Afr Med J 48: 2508a–2508d.

    PubMed  Google Scholar 

  • Van Rensburg SJ, Cook-Mozaffari P, Van Schalkwyk DJ, Van Der Watt JJ, Vincent TJ, Purchase IF (1985) Hepatocellular carcinoma and dietary aflatoxin in Mozambique and Transkei. Brit J Cancer 51: 713–726.

    Article  PubMed  Google Scholar 

  • Wagstaff DJ (1985) The use of epidemiology, scientific data, and regulatory authority to detemine risk factors in cancers of some organs of the digestive tract. 3. Liver cancer. Reg Toxicol Pharmacol 5: 384–404.

    Article  CAS  Google Scholar 

  • Wagstaff DJ (1990) Epidemiologic studies of the association of aflatoxin exposure and human liver cancer. In: Proceedings of Symposium on Perspective on Aflatoxin in Field Crops and Animal Food Products in the United States, Washington, DC, Jan 23–24, 1990. ARS-83; pp 141–147.

    Google Scholar 

  • Wilson, BJ (1978) Hazards of mycotoxins to public health. J Food Protect 41: 5: 375–384.

    Google Scholar 

  • Wogan GN, Newberne PM (1967) Dose-response characteristics of aflatoxin B1 carcinogenesis in the rat. Cancer Res 27: 2370.

    PubMed  CAS  Google Scholar 

  • Wolzak A, Pearson AM, Coleman TH, Pestka JJ, Gray JI (1985) Aflatoxin deposition and clearance in the eggs of laying hens. Food Chem Toxicol 23: 1057–1061.

    Article  PubMed  CAS  Google Scholar 

  • Wyatt RD, Ruff MD, Page RK (1975) Interaction of aflatoxin with Elmera tenella infection and monensin in young broiler chickens. Avian Dis 19 (4): 730–740.

    Article  PubMed  CAS  Google Scholar 

  • Yang WC (1983) Effects of aflatoxin Bj on the development of porcine cellular and humoral immune responses. Dissertaion Abs Int 44/06–B: 1778.

    Google Scholar 

  • Yeh FS, Yu MC, Mo CC, Luo S, Tong MJ, Henderson BE (1989) Hepatitis B virus, aflatoxins, and hepatocellular carcinoma in southern Guangxi, China. Cancer Res 49: 2506–2509.

    PubMed  CAS  Google Scholar 

  • Zhu JQ, Zhang LS, Hu X, Xiao Y, Chen JS, Xu YC, Fremy J, Chu FS (1987) Correlation of dietary aflatoxin B1 levels with excretion of aflatoxin M1 in human urine. Cancer Res 47: 1848–1852.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. USDA, ARS, NPS, APHS, Building 005, Barc-West, Room 210, Beltsville, MD, 20705, USA

    J. F. Robens

  2. National Center for Agricultural Utilization Research, 1815 North University Street, Peoria, IL, 61604-3999, USA

    J. L. Richard

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  1. J. F. Robens
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  1. College of Agriculture, University of Arizona, 85721, Tucson, Arizona, USA

    George W. Ware

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© 1992 Springer-Verlag New York, Inc.

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Robens, J.F., Richard, J.L. (1992). Aflatoxins in Animal and Human Health. In: Ware, G.W. (eds) Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology, vol 127. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9751-9_3

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  • DOI: https://doi.org/10.1007/978-1-4613-9751-9_3

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