Complications of Bacterial Meningitis
Acute bacterial meningitis remains an important problem in contemporary medical practice, marked by continued significant mortality and morbidity in spite of antibiotics that are very active against the common pathogens. The age of the patient, infecting organism, and time to diagnosis are the most important determinants of outcome, with death occurring in 3–70% of patients and neurologic residua affecting 10–50% of survivors.1 While survival and level of neurologic function remain the primary considerations when one deals with the complications of meningitis, it is important to recognize that the disease process is a dynamic one, and that different phases present the clinician with varying problems that commonly occur at those times. In order to optimize care, the clinician must manage the patient in an anticipatory fashion, with a thorough understanding of the evolving illness.
KeywordsIntracranial Pressure Bacterial Meningitis Brain Edema Intracranial Hypertension Brain Abscess
Unable to display preview. Download preview PDF.
- 1.Klein JO, Feigin RD, McCarcken GH Jr: Report of the Task Force on Diagnosis and Management of Meningitis. Pediatrics 1986; 78: 959–982. 16.Google Scholar
- 5.Täuber MG, Shibl AM, Hackbarth CJ, et al: Antibi- 19. otic therapy, endotoxin concentration in cerebrospinal fluid, and brain edema in experimental Escherechia coli meningitis in rabbits. J Infect Dis 1987; 156: 456–462. 20.Google Scholar
- 7.Täuber MG, Borschberg U, Sande MA: Influence of 21. granulocytes on brain edema, intracranial pressure, and cerebrospinal fluid concentration of lactate and protein in experimental meningitis. J. Infect Dis 22. 1988; 157: 456.Google Scholar
- 13.Tureen JH, Stella FB, Clyman RI, et al: Effect of indomethacin on brain water content, cerebrospinal fluid white blood cell response and prostaglandin E2 levels in cerebrospinal fluid in experimental pneumococcal meningitis in rabbits. Ped Infect Dis J 1987; 6: 1151–1153.Google Scholar
- 15.Smith AL. Pathogenesis of Haemophilus influenzae, type b meningitis, in Deusch G, Wadstrom T (eds.): Experimental Bacterial and Parasitic Infections. New York, Elsevier Science Publishing, 1983, p 295.Google Scholar
- 19.Tureen JH, Sande MA: Acute bacterial infections of the central nervous system, in Aminoff MJ (ed): Neurology and General Medicine. New York: Churchill Livingstone, 1989; pp 559–575.Google Scholar