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Prognostic and Pathogenetic Implications of Immune Complexes in Human Cancer

  • F. A. Salinas
  • K. H. Wee
Part of the Advances in Immunity and Cancer Therapy book series (IMMUNITY, volume 2)

Abstract

Serum markers for the diagnosis and monitoring of cancer have been demonstrated to be generally nonspecific (1). The evaluation of circulating immune complexes (CIC) has proven useful for following the clinical course of disease in cancer patients (2–8). High levels of CIC have been indicative of increased tumor burden and poor prognosis in malignant melanoma (9,10), breast carcinoma (11,12), ovarian carcinoma (13), neuroblastoma (14), gastrointestinal carcinoma (15), lung carcinoma (16), sarcoma (105), bone tumors (17), and leukemias (18). Initially, only tumor-associated antibodies were considered responsible for the immunomodulation observed in cancer patients, but currently tumor-associated immune complexes and their antigens have been demonstrated to have a major “blocking factors” role (19,20,54). Also, CIC have been shown to modulate tumoricidal activity of macrophages (21), natural killer (NK) cells (22), and antibody-dependent cytotoxicity (16,23).

Keywords

Immune Complex Tumor Burden Circulate Immune Complex Fetal Liver Cell Oncofetal Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used in text

BCG

Bacillus Calmette Guerin

CIC

circulating immune complexes

FLC

fetal liver cell

HOFA

human oncofetal antigen

MAA

melanoma associated antigens

NK

natural killer cells

NCS

normal control sera

PEG

polyethylene glycol

RIA

radioimmunoassay

SDS-PAGE

sodium dodecyl sulfate-polyacrylamide gel electrophoresis

SGF

sucrose gradient fractionation

XOFA

xenogeneic oncofetal antigens

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© Springer-Verlag New York Inc. 1986

Authors and Affiliations

  • F. A. Salinas
  • K. H. Wee

There are no affiliations available

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