Abstract
In earlier chapters, we discussed the structures of biological membranes and the relationship of structure to basic membrane functions, such as compartmentation, transport, and molecular reception. We saw that, by and large, membranes in unicellular organisms perform the same functions as those in more complex biologic systems. In this chapter, regulatory interactions in multicellular organisms will be discussed, interactions that may prove to be far more complex than those occurring in unicellular organisms. We shall consider the role of the cytoplasmic membrane in mammalian cell growth regulation and carcinogenesis. In spite of the complexity of the problems at hand and the paucity of concrete information on this subject, the possible relevance of microbial studies to cell surface-mediated growth regulation will be discussed.
The cell is a wonderfully complex and precise little mechanism; disease is but disorder of this mechanism.
The aim of medicine is to prevent or repair such disorders.
The aim of biology is to understand the cellular machinery.
A. Szent-Györgyi
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Selected References
Brink, R. A. “Paramutation,” in Annual Review of Genetics, Vol. 7. Annual Reviews, Inc., Palo Alto, Calif., 1974, p. 129.
Brooke, R. F. “Growth regulationin vitro and the role of serum,” in Structure and Function of Plasma Proteins (A. C. Allison, ed.). Plenum Press, New York, 1975.
Clarkson, B. and R. Baserga (eds.). Control of Proliferation in Animal Cells. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1974.
Lino, T. Genetics and chemistry of bacterial flagella. Bacteriol. Rev., 33: 454 (1969).
Pollack, R. (ed.). Readings in Mammalian Cell Culture. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1974.
Wright, A. and S. Kanegasaki. Molecular aspects of lipopolysaccharides. Physiol. Rev., 51: 748 (1971).
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© 1975 Springer-Verlag New York Inc.
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Saier, M.H., Stiles, C.D. (1975). Role of the Plasma Membrane In Growth Regulation and Neoplasia. In: Molecular Dynamics in Biological Membranes. Heidelberg Science Library. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9399-3_10
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DOI: https://doi.org/10.1007/978-1-4613-9399-3_10
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-90142-8
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