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Artificial and Reconstituted Membrane Systems pp 229–278Cite as

Lectin-Carbohydrate Interactions in Model and Biological Membrane Systems

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Part of the book series: Subcellular Biochemistry ((SCBI,volume 14))

Abstract

Many of the diverse activities of cells are manifested at the cell surface; that is, the start of many intracellular events find their origin in a signal triggered at the cell surface. Such a response may arise from the specific attachment of macromolecules to carbohydrate-bearing molecules (glycolipids and glycoproteins), which are abundantly present at the outer surface of the plasma membrane. Typical examples include the operation of hormones and toxins (Kelly et al., 1979; Neville and Hudson, 1986; Ross and Gilman, 1980). Glycoconjugates, covalently linked to either lipids or proteins, also mediate the attachment of certain viruses, representing the initial event in the viral entry mechanism that eventually may lead to infection (Bächi et al., 1977; Hoekstra et al., 1988; White et al, 1983). Secretory processes (Ling et al., 1985), mitogenic effects (Rosoff et al., 1987), myotube production from myoblasts (Cates et al., 1984; Knudsen, 1985), and the formation of multinucleate macrophages during the inflammatory response (Papadimitriou, 1978) further illustrate the variety of cell surface mediated responses. The origin of these events can be traced back to a specific association between external macromolecules and cell surface glycolipids and/or glycoproteins that act as a specific receptor and transmitting unit for these responses. The diversity, specificity, and frequency by which these responses occur throughout the biological life of the cell also dictate that the macromolecule itself, which recognizes the specific code provided by the carbohydrate part of the receptor, displays a high degree of specificity.

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Abbreviations

CL:

cardiolipin

ConA:

concanavalin A

CTL:

Croton tiglium lectin

DPPC:

dipalmitoylphosphatidylcholine

DSC:

differential scanning calorimetry

EDTA:

ethylenediaminetetraacetic acid

Fuc:

fucose

Gal:

galactose

GalCer:

galactosylceramide, Galβ1-lCer

GalNAc:

N-acetylgalactosamine

Gb3 :

trihexosylceramide, Galα1-4Galβ1-4G1cβ1-1 Cer

Gb4 :

globoside, GalNAcβ1-3Galα1-4Galβ1-4Glcβ1-1Cer

GDla :

NeuAcα2-3Galβ1-3GalNAcβ1-4[NeuAcα2-3]Galβ1-4Glcβ1-1Cer

GD3 :

Neu Acα2-8NeuAcα2-3Galβ1-4Glcβ1-1Cer

Glc:

Glucose

GlcNAc:

N-acetylglucosamine

GluCer:

glucosylceramide, Gluβ1-lCer

GM1 :

Galβ1-3GalNAcβ1-4[NeuAcα2-3]Galβ1-4Glcβ1-1Cer

GTlb :

NeuAcα2-3Galβ1-3GalNAcβ1-4[NeuAcα2-3]Galβ1-4Glcβ1-lCer

LacCer:

lactosylceramide, Galβ1-4Gluβ1-1Cer

Man:

mannose

Man-6-P:

mannose-6-phosphate

NANA or NeuAc:

N-acetylneuraminic acid

PA:

phosphatidic acid

PC:

phosphatidylcholine

PHA:

phytohemagglutinin

PS:

phosphatidylserine

RCA:

Ricinus communis agglutinin

SBA:

soy bean agglutinin

WGA:

wheat germ agglutinin

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Author information

Authors and Affiliations

  1. Laboratory of Physiological Chemistry, University of Groningen, 9712 KZ, Groningen, The Netherlands

    Dick Hoekstra

  2. Cancer Research Institute and Department of Pharmaceutical Chemistry, University of California, 94143-0128, San Francisco, California, USA

    Nejat Düzgüneş

Authors
  1. Dick Hoekstra
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  2. Nejat Düzgüneş
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Editor information

Editors and Affiliations

  1. North East Thames Regional Transfusion Centre, Brentwood, Essex, England

    J. R. Harris

  2. University of Paris VI, Paris, France

    A.-H. Etémadi

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© 1989 Plenum Press, New York

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Hoekstra, D., Düzgüneş, N. (1989). Lectin-Carbohydrate Interactions in Model and Biological Membrane Systems. In: Harris, J.R., Etémadi, AH. (eds) Artificial and Reconstituted Membrane Systems. Subcellular Biochemistry, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-9362-7_6

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  • DOI: https://doi.org/10.1007/978-1-4613-9362-7_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-9364-1

  • Online ISBN: 978-1-4613-9362-7

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