Liposomes as Carriers of Drugs Observations on Vesicle Fate after Injection and Its Control
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Detailed knowledge of the behavior of liposomes (phospholipid vesicles) after injection is a prerequisite for their successful application as drug carriers in the therapy, prevention, or detection of disease (Gregoriadis, 1980). This discussion deals with two aspects: (1) the extent to which vesicles retain entrapped agents in the presence of biological fluids, namely, blood and (2) the rate by which vesicles are cleared from the circulation and their distribution in tissues. Evaluation of the first is likely to lead to methods of preventing or reducing agent leakage from the carrier en route to its target site. Study of the second aspect will contribute to the elucidation of the mechanism(s) through which vesicles leave the circulation to end up in tissues and also allow manipulations controlling vesicle clearance or uptake by tissues in need of pharmacological intervention. Both aspects have been discussed in detail elsewhere (Gregoriadis, 1983; Gregoriadis et al, 1983; Senior, 1987).
KeywordsCholesterol Content Vesicle Size Plasma High Density Lipoprotein Unilamellar Liposome Multilamellar Liposome
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