Drusen have been described as autosomal dominant lesions. Excrescences or nodules seen on the surface of Bruch’s membrane, they may be dystrophic and familial. Characteristically, drusen located throughout the posterior pole as well as nasal to the disc for which a familial pattern can be demonstrated are commonly called dominant drusen or familial drusen. Ophthalmoscopically, they are yellow to yellow-white and are located in deep retina. They appear during the first three decades of life and are usually round. As the individual ages, the drusen may coalesce. During the fifth or sixth decade of life, a pigment epithelial detachment may occur that signals the presence of a subretinal neovascular membrane. Patients do not notice a loss of acuity until after age 40. Clinically, the number and size of the drusen increase over time.
KeywordsRetinal Pigment Epithelium Color Vision Sixth Decade Pigment Epithelial Detachment Normal Color Vision
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