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Optic Nerve Hypoplasia and Megalopapilla

  • Juan Orellana
  • Alan H. Friedman

Abstract

Children with optic nerve hypoplasia may have multiple endocrine and central nervous system problems. The discs in these patients have fewer nerve fibers than normal, and there is a deficiency of the retinal ganglion cells. There have been reports of anencephaly and hydranencephaly. De Morsier syndrome has also been described in patients with optic nerve hypoplasia. De Morsier syndrome patients have an absence of the septum pellucidum, partial or complete agenesis of the corpus callosum, pituitary dysfunction, and dysplasia of the third ventricle. Apert syndrome and Meckel syndrome are two other conditions in which optic nerve hypoplasia may coexist. There may be an association with maternal ingestion of quinine, phenytoin, lysergic acid diethylamide (LSD), meperidine, and diuretics as well. It can also be seen in children of diabetic mothers.

Keywords

Optic Nerve Optic Disc Retinal Ganglion Cell Diabetic Mother Optic Canal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Selected Reading

  1. Acers TE (1981). Optic nerve hypoplasia: septo-optic-pituitary dysplasia syndrome. Trans Am Ophthalmol Soc 79: 425–457PubMedGoogle Scholar
  2. Franeschetti A, Bock RH (1950). Megalopapilla: a new congenital anomaly. Am J Ophthalmol 33: 227–235Google Scholar
  3. Petersen RA, Walton DS (1977). Optic nerve hypoplasia with good visual acuity and visual field defects: a study of children of diabetic mothers. Arch Ophthalmol 95: 254–258PubMedCrossRefGoogle Scholar
  4. Skarf B, Hoyt CS (1984). Optic nerve hypoplasia in children: association with anomalies of the endocrine and CNS. Arch Ophthalmol 102: 62–67PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Juan Orellana
    • 1
  • Alan H. Friedman
    • 1
  1. 1.Mount Sinai School of MedicineNew YorkUSA

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