Abstract
Shortly after the initiation of meiosis in oocytes during fetal life, this process becomes arrested at the diplotene stage. This arrest is sustained by the presence of meiosis-arresting substances within the oocyte (1) and by the absence of factors essential for the progression of meiosis (2). As the oocytes near completion of their growth phase, about the time of follicular antrum formation, they become competent to resume meiosis but remain arrested within the follicle because of the meiosis-arresting action of the somatic cells comprising the follicle wall (3–5). Meiosis normally resumes in response to the preovulatory surge of luteinizing hormone (LH) (6) but also resumes spontaneously, in the absence of gonadotropins, when the oocyte is removed from the follicle and cultured in a supportive medium (7, 8). Some oocytes in early antral follicles are competent to resume meiosis but are unable to progress to metaphase II (9). Therefore, germinal vesicle breakdown (GVBD) and subsequent completion of meiosis I are distinctly separable in oocytes and are sequentially acquired. Furthermore, oocytes must become capable of producing additional factors to progress beyond the initial stages of oocyte maturation.
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Eppig, J.J. (1993). Establishment of Competence for Preimplantation Embryogenesis during Oogenesis in Mice. In: Bavister, B.D. (eds) Preimplantation Embryo Development. Serono Symposia, USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9317-7_4
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DOI: https://doi.org/10.1007/978-1-4613-9317-7_4
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