Skip to main content

Parental Imprinting in Mammalian Development

  • Conference paper
Preimplantation Embryo Development

Part of the book series: Serono Symposia, USA Norwell, Massachusetts ((SERONOSYMP))

  • 101 Accesses

Abstract

The basic laws of Mendelian genetics tell us that an equal genetic contribution is inherited from each parent and that these inherited genes function equally in the offspring. Studies in the mouse, however, have shown that for some genes this is not the case, and the finding that parental genomes were not functionally equivalent has established the study of parental imprinting as one of the most exciting areas of genetic regulation at this time.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Surani MAH, Barton SC, Norris ML. Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis. Nature (London) 1984;308:548–50.

    Article  PubMed  CAS  Google Scholar 

  2. Solter D. Differential imprinting and expression of maternal and paternal genomes. Annu Rev Genet 1988;22:127–46.

    Article  PubMed  CAS  Google Scholar 

  3. Cattanach BM. Parental origin effects in mice. J Embryol Exp Morphol 1986;97:137–50.

    PubMed  Google Scholar 

  4. Searle AG, Beechey CV. Noncomplementation phenomena and their bearing on nondisjunctional events. In: Dellarco VL, et al., eds. Aneuploidy. New York: Plenum Press, 1985:363–76.

    Google Scholar 

  5. Johnston DR. Further observations on the hairpin-tail (Thp) mutation in the mouse. Genet Res 1974;24:207–13.

    Article  Google Scholar 

  6. Winking H, Silver L. Characterisation of a recombinant mouse t-haplotype that expresses a dominant lethal maternal effect. Genetics 1984;108:1013–20.

    PubMed  CAS  Google Scholar 

  7. Barlow DP, Stoger R, Herrman BG, Saito K, Schweifer N. The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus. Nature (London) 1991;349:84–7.

    Article  PubMed  CAS  Google Scholar 

  8. Searle AG, Beechey CV. Genome imprinting phenomena on mouse chromosome 7. Genet Res 1990;56:237–44.

    Article  PubMed  CAS  Google Scholar 

  9. Ferguson-Smith AC, Cattanach BM, Barton SC, Beechey CV, Surani MA. Embryological and molecular investigations of parental imprinting on mouse chromosome 7. Nature (London) 1991;351:667–70.

    Article  PubMed  CAS  Google Scholar 

  10. DeChiara TM, Efstratiadis A, Robertson EJ. A growth deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targetting. Nature (London) 1990;345:78–80.

    Article  PubMed  CAS  Google Scholar 

  11. DeChiara TM, Robertson EJ, Efstratiadis A. Parental imprinting of the mouse, insulin-like growth factor II gene. Cell 1991;64:849–59.

    Article  PubMed  CAS  Google Scholar 

  12. Mansour SL, Thomas KP, Deng CX, Cappecchi MR. Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination. Proc Natl Acad Sci USA 1990;87:7688–92.

    Article  PubMed  CAS  Google Scholar 

  13. Bartolemei MS, Zemel S, Tilghman SM. Parental imprinting of the mouse H19 gene. Nature (London) 1991;351:153–5.

    Article  Google Scholar 

  14. Brannan CI, Dees EC, Ingram RS, Tilghman S. The product of the H19 gene may function as an RNA. Mol Cell Biol 1990;10:28–36.

    PubMed  CAS  Google Scholar 

  15. Fundele RH, Norris ML, Barton SC, Reik W, Surani MA. Systematic elimination of parthenogenetic cells in mouse chimaeras. Development 1989; 106:28–35.

    Google Scholar 

  16. Fundele RH, Norris ML, Barton SC, et al. Temporal and spatial selection against parthenogenetic cells during development of fetal chimaeras. Development 1990;108:203–11.

    PubMed  CAS  Google Scholar 

  17. Fundele R, Howlett SK, Kothary R, Norris ML, Mills WE, Surani MA. Developmental potential of parthenogenetic cells: role of genotype-specific modifiers. Development 1991;113:941–6.

    PubMed  CAS  Google Scholar 

  18. Barton SC, Ferguson-Smith AC, Fundele RH, Surani MA. Influence of paternally imprinted genes on development. Development 1991;113:679–88.

    PubMed  CAS  Google Scholar 

  19. Heyner S, Smith R, Schultz GA. Temporally regulated expression of insulin and insulin-like growth factors and their receptors in early mammalian development. Bioessays 1989;11:171–6.

    Article  PubMed  CAS  Google Scholar 

  20. Morgan DO, Edman JC, Standring DN, et al. Insulin-like growth factor II receptor as a multifunctional binding protein. Nature (London) 1987;329: 301–7.

    Article  PubMed  CAS  Google Scholar 

  21. Haig D, Graham C. Genomic imprinting and the strange case of the insulinlike growth factor II receptor. Cell 1991;64:1045–6.

    Article  PubMed  CAS  Google Scholar 

  22. Moore T, Haig D. Genomic imprinting in mammalian development: a parental tug-of-war. Trends Genet 1991;7:45–9.

    PubMed  CAS  Google Scholar 

  23. Ferguson-Smith AC, Reik W, Surani MA. Genomic imprinting and cancer. Cancer Surveys 1990;9:487–503.

    PubMed  CAS  Google Scholar 

  24. Reik W. Genomic imprinting and genetic disorders in man. Trends Genet 1989;5:331–6.

    Article  PubMed  CAS  Google Scholar 

  25. Kajii T, Ohama K. Androgenetic origin of hydatidiform moles. Nature (London) 1977;268:633–4.

    Article  PubMed  CAS  Google Scholar 

  26. Bagshawe KD, Lawler SD. Unmasking moles. Br J Obstet Gynaecol 1982; 89:255–9.

    Article  PubMed  CAS  Google Scholar 

  27. Hall J. Genomic imprinting: review and relevance to human diseases. Am J Hum Genet 1990;46:857–73.

    PubMed  CAS  Google Scholar 

  28. Henry I, Bonaiti-Pellie C, Chehensse V, et al. Uniparental paternal disomy in a genetic cancer-predisposing syndrome. Nature (London) 1991;351:665–7.

    Article  PubMed  CAS  Google Scholar 

  29. Little M, Van Heyningen V, Hastie N. Dads and disomy and disease. Nature (London) 1991;351:609–10.

    Article  PubMed  CAS  Google Scholar 

  30. Reeve AE, Eccles MR, Wilkins RJ, Bell GI, Millow LJ. Expression of insulin-like growth factor II transcripts in Wilms’ tumour. Nature (London) 1985;317:258–60.

    Article  PubMed  CAS  Google Scholar 

  31. Scott J, Cowell J, Robertson ME, Priestley LM, et al. Insulin-like growth factor II gene expression in Wilms’ tumour and embryonic tissues. Nature (London) 1985;317:260–2.

    Article  PubMed  CAS  Google Scholar 

  32. Knoll JHM, Nicholls RD, Magenis RE, Graham JM, Lalande M, Latt SA. Angelman and Prader-Willi syndrome share a common chromosome 15 deletion but differ in parental origin of the deletion. Am J Med Genet 1989; 32:285–90.

    Article  PubMed  CAS  Google Scholar 

  33. Malcolm S, Nichols M, Clayton-Smith J, et al. Angelman syndrome can result from uniparental disomy. Am J Hum Genet 1990;47:A227.

    Google Scholar 

  34. Nicholls RD, Knoll JHM, Butler MG, Karam S, Lalande M. Genetic imprinting suggested by maternal disomy heterodisomy in non-deletion Prader-Willi syndrome. Nature (London) 1989;342:281–5.

    Article  PubMed  CAS  Google Scholar 

  35. Reik W, Collick A, Norris ML, Barton SC, Surani MAH. Genomic imprinting determines methylation of parental alleles in transgenic mice. Nature (London) 1987;238:248–51.

    Article  Google Scholar 

  36. Yen PH, Patel P, Chinault AC, Mohandas T, Shapiro LJ. Differential methylation of hypoxanthine phosphoribosyltransferase genes on active and inactive X-chromosome. Proc Natl Acad Sci USA 1984;81:1759–63.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag New York, Inc.

About this paper

Cite this paper

Ferguson-Smith, A.C., Surani, M.A. (1993). Parental Imprinting in Mammalian Development. In: Bavister, B.D. (eds) Preimplantation Embryo Development. Serono Symposia, USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9317-7_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-9317-7_11

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-9319-1

  • Online ISBN: 978-1-4613-9317-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics