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Mutations Affecting Early Development in the Mouse

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Preimplantation Embryo Development

Part of the book series: Serono Symposia, USA Norwell, Massachusetts ((SERONOSYMP))

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Abstract

Mutations are important for defining and dissecting complex pathways of normal development and for relating biological function to protein structure. Most of the known mutations in mouse have occurred spontaneously and were identified because of visible phenotypic effects associated with the mutated gene in the heterozygous state. More recently, an intense effort has been under way to induce random or site-directed germ-line mutations. For example, the specific-locus method has been used to generate mutations in localized regions of the genome (1). Irradiated animals are mated to a test stock homozygous for a number of visible markers. The resulting array of mutations, many of which are deletions, are detected because of visible phenotypes produced in F1 offspring. The deletions are useful for studying the marker locus as well as the surrounding chromosomal region. The dilute-short ear-deletion complex of chromosome 9 (2, 3) and the albino-deletion complex of chromosome 7 (4–7) represent two examples of this approach.

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Authors
  1. Terry Magnuson
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  2. Shyam K. Sharan
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  3. Bernadette Holdener-Kenny
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Editor information

Editors and Affiliations

  1. Department of Animal Health and Biomedical Sciences, University of Wisconsin-Madison, 53706, Madison, WI, USA

    Barry D. Bavister Ph.D.

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© 1993 Springer-Verlag New York, Inc.

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Magnuson, T., Sharan, S.K., Holdener-Kenny, B. (1993). Mutations Affecting Early Development in the Mouse. In: Bavister, B.D. (eds) Preimplantation Embryo Development. Serono Symposia, USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9317-7_10

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  • DOI: https://doi.org/10.1007/978-1-4613-9317-7_10

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-9319-1

  • Online ISBN: 978-1-4613-9317-7

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