Detection and Characterization of Circulating ICAM-1
Over the past several years, the expression of intercellular adhesion molecule-1 (ICAM-1) on cells from normal and diseased tissue has been extensively studied. Almost as soon as ICAM-1 was identified, it was found to be a cell-surface adhesion molecule that was inducible in vitro with inflammatory cytokines such as IL-1, TNFα, and IFNγ on a multitude of cell types. Furthermore, ICAM-1’s expression on cells from normal and diseased tissue has been and continues to be a focus of much research from many laboratories. To date, it has been reported that there is a low constitutive expression of ICAM-1 on venule endothelial cells; however, its expression is markedly increased at inflammatory sites (1). Furthermore, there is an increased ICAM-1 expression on multiple cell types including keratinocytes in inflammatory skin lesions (2,3), transplanted liver bile duct and perivenular hepatocytes during rejection (4), and in cases of primary biliary cirrhosis (5), endothelium in the brain surrounding MS plaques and EAE lesions in man and rodent, respectively (6–12), transplanted kidney glomeruli and tubules during rejection (13), as well as lung epithelial cells following antigen provocation (14). Increased ICAM-1 is also found on melanoma cells following metastasis (15,16) and recently ICAM-1 expression has been shown to be expressed on placental macrophages and decidua during pregnancy.
KeywordsLymphoma Adenocarcinoma Interferon Integrin Dermatitis
Dustin, M.L., R. Rothlein, A.K. Bhan, C.A. Dinarello, and T.A. Springer. 1986. Induction by IL-1 and interferon, tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol.
Vejlsgaard, G.L., E. Ralfkiaer, C. Avnstorp, M. Czajkowski, S.D. Marlin, and R. Rothlein. 1989. Kinetics and characterization of intercellular adhesion molecule-1 (ICAM-1) expression on keratinocytes in various inflammatory skin lesions and malignant cutaneous lymphomas. J. Amer. Acad. Dermtol.
Griffiths, C.E.M. and B.J. Nickoloff. 1989. Keratinocyte intercellular adhesion molecule-1 (ICAM-1) expression precedes dermal T lymphocytic infiltration in allergic contact dermatitis (Rhus dermatitis). Am. J. Pathol.
Adams, D.H., S.G. Hubscher, J. Shaw, R. Rothlein, and J.M. Neuberger. 1989. Intercellular adhesion molecule 1 on liver allografts during rejection. Lancet
Adams, D.H., S.G. Hubscher, J. Shaw, G.D. Johnson, C. Babbs, R. Rothlein, and J.M. Neuberger. 1991. Increased expression of intercellular adhesion molecule 1 on bile ducts in primary biliary cirrhosis and primary sclerosing cholangitis. Hepatology
Sobel, R.A., M.E. Mitchell, and G. Fondren. 1990. Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system. Am. J. Pathol.
Frohman, E.M., T.C. Frohman, M.L. Dustin, B. Vayuvegula, B. Choi, A. Gupta, S. van den Noort, and S. Gupta. 1989. Induction of ICAM-1 expression on human fetal astrocytes by interferon-gamma, tumor necrosis factor-alpha and interleukin-1: relevance to intracerebral antigen presentation. J. Neuroimmunol.
Raine, C.S., S.C. Lee, L.C. Scheinberg, A.M. Duijvestijn, and A.H. Cross. 1990. Adhesion molecules on endothelial cells in the central nervous system: An emerging area in the neuroimmunology of multiple sclerosis. Clin. Immunol. Immunopathol.
Cannella, B., A.H. Cross, and C.S. Raine. 1990. Upregulation and coexpres-sion of adhesion molecules correlate with relapsing autoimmune demyelina-tion in the central nervous system. J. Exp. Med.
Cannella, B., A.H. Cross, and C.S. Raine. 1991. Adhesion-related molecules in the central nervous system: Upregulation correlates with inflammatory cell influx during relapsing experimental autoimmune encephalomyelitis. Lab. Invest.
Raine, C.S. 1991. Multiple sclerosis: A pivotal role for the T cell in lesion development. Neuropathol. Appl. Neurobiol.
Wilcox, C.E., A.M.V. Ward, A. Evans, D. Baker, R. Rothlein, and J.L. Turk. 1990. Endothelial cell expression of the intercellular adhesion molecule-1 (ICAM-1) in the central nervous system of guinea pigs during acute and chronic relapsing experimental allergic encephalomyelitis. J.
Cosimi, A.B., D. Conti, F.L. Delmonico, F.I. Preffer, S.-L. Wee, R. Rothlein, R. Faanes, and R.B. Colvin. 1990. In vivo effects of monoclonal antibody to ICAM-1 (CD54) in nonhuman primates with renal allografts. J.
Wegner, CD., R.H. Gundel, P. Reilly, N. Haynes, L.G. Letts, and R. Rothlein. 1990. Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma. Science
Matsui, M., M. Temponi, and S. Ferrone. 1987. Characterization of a monoclonal antibody-defined human melanoma-associated antigen susceptible to induction by immune interferon. J.
Natali, P., M.R. Nicotra, R. Cavaliere, A. Bigotti, G. Romano, M. Temponi, and S. Ferrone. 1990. Differential expression of intercellular adhesion molecule 1 in primary and metastatic melanoma lesions. Cancer Res.
Staunton, D.E., S.D. Marlin, C. Stratowa, M.L. Dustin, and T.A. Springer. 1988. Primary structure of intercellular adhesion molecule 1 (ICAM-1) demonstrates interaction between members of the immunoglobulin and integrin supergene families. Cell
Simmons, D., M.W. Makgoba, and B. Seed. 1988. ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM. Nature
Greve, J.M., G. Davis, A.M. Meyer, C.P. Forte, S.C. Yost, C.W. Marlor, M.E. Kamarck, and A. McClelland. 1989. The major human rhinovirus receptor is ICAM-1. Cell
Staunton, D.E., V.J. Merluzzi, R. Rothlein, R. Barton, S.D. Marlin, and T.A. Springer. 1989. A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses. Cell
Marlin, S.D., D.E. Staunton, T.A. Springer, C. Stratowa, W. Sommergruber, and V.J. Merluzzi. 1990. A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection. Nature
Rubin, L.A., C.C. Kurman, M.E. Fritz, W.E. Biddison, B. Boutin, R. Yarchoan, and D.L. Nelson. 1985. Soluble interleukin receptors are released from activated human lymphoid cells in vitro. J.
Gordon, J., J.A. Cairns, M.J. Millsum, G.R. Guy, and S. Gillis. 1988. Interleukin and soluble CD23 as progression factors for human B-lymphocytes. Eur. J. Immunol.
Rothlein, R., E.A. Mainolfi, M. Czajkowski, and S.D. Marlin. 1991. A form of circulating ICAM-1 in human serum. J. Immunol.
Kishimoto, T.K. and T.A. Springer. 1989. Human leukocyte adhesion deficiency: Molecular basis for a defective immune response to infections of the skin. In Current Problems in Dermatology. 18:106.Google Scholar
Ballantyne, C., E.A. Mainolfi, J.B. Young, N.T. Windsor, B. Cocanougher, E.C. Lawrence, D.C. Anderson, and R. Rothlein. 1991. Prognostic value of increased levels of circulating intercellular adhesion adhesion molecule-1 after heart transplant. Clin. Res.
Adams, D.H., E.A. Mainolfi, J. Neuberger, E. Elias, and R. Rothlein. 1991. Secretion of circulating ICAM-1 into bile during liver allograft rejection. Gut
Adams, D.H., P. Burra, E.A. Mainolfi, J. Nueberger, E. Elias, and R. Rothlein. 1991. Circulating ICAM-1 in chronic liver disease: evidence for lymphocyte activation in PBC and PSC. J. Hepatol.
Johnson, J.P., B.G. Stade, B. Holzmann, W. Schwable, and G. Riethmuller. 1989. De novo expression of intercellular-adhesion molecule 1 in melanoma correlates with increased risk of metastasis. Proc. Natl. Acad. Sci. U. S. A.
Harning, R., E.A. Mainolfi, J.C. Bystryn, M. Henn, V.J. Merluzzi, and R. Rothlein. 1991. Serum levels of circulating intercellular adhesion molecule 1 in human malignant melanoma. Cancer Res.
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