Cytokines and the Control of Endothelial Cell Adhesiveness for Leukocytes in Inflammation

  • Dorian O. Haskard
  • Martin H. Thornhill
Conference paper

Abstract

Over the last few years there has been considerable attention paid to understanding the mechanisms by which circulating leukocytes gain access to the tissues during inflammatory responses (1–3). Direct inspection of the microvasculature in inflammatory tissues has shown that leukocytes “roll” along the vessel wall before becoming flattened on the endothelial surface. Adherent leukocytes then put out pseudopodia and migrate between endothelial cells (EC) into the tissues (4–6). These events appear to be very similar at the cellular level for all types of leukocyte and depend both upon chemoattractive factors that directly activate leukocyte function and upon factors which alter the adhesive state of the endothelium. Important differences, however, may exist in the nature and regulation of endothelial ligands for leukocytes of different lineage.

Keywords

Migration Interferon Histamine Thrombin 

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References

  1. 1.
    Carlos, T.M. and J.M. Harlan. 1990. Membrane proteins involved in phagocyte adherence to endothelium. Immunol. Rev. 114:5.PubMedCrossRefGoogle Scholar
  2. 2.
    Osborn, L. 1990. Leukocyte adhesion to endothelium in inflammation. Cell 62:3PubMedCrossRefGoogle Scholar
  3. 3.
    Thornhill, M.H. and D.O. Haskard. 1991. Lymphocyte adhesion in inflammation. In Vascular Endothelium: Interactions With Circulating Cells. J.L. Gordon, ed. Elsevier, Amsterdam, pp. 93–112.Google Scholar
  4. 4.
    Cohnheim, J. 1989. Lectures on General Pathology: A Handbook for Practitioners and Students. The New Sydenham Society, London.Google Scholar
  5. 5.
    Florey, H.W. and L.H. Grant. 1961. Leucocyte migration from small blood vessels stimulated with ultra-violet light: an electron microscope study. J. Path. Bact. 82:13.PubMedCrossRefGoogle Scholar
  6. 6.
    Atherton, A. and G.V.R. Born. 1972. Quantitative investigations of the adhesiveness of circulating polymorphonuclear leukocytes to blood vessel walls. J. Physiol. 222:447.PubMedGoogle Scholar
  7. 7.
    Geng, J.-G., M.P. Bevilacqua, K.L. Moore, T.M. McIntyre, S.M. Prescott, J.M. Kim, G.A. Bliss, G.A. Zimmerman, and R.P. McEver. 1990. Rapid neutrophil adhesion to activated endothelium mediated by GMP-140. Nature 343:757.PubMedCrossRefGoogle Scholar
  8. 8.
    Pober, J.S. and R.S. Cotran. 1990. Cytokines and endothelial cell biology. Physiol. Rev. 70:427.PubMedGoogle Scholar
  9. 9.
    Dixit, V.M., S. Green, V. Sarma, L.B. Holzman, F.W. Wolf, K. O’Rourke, P.A. Ward, E.V. Prochownik, and R.M. Marks. 1990. Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin. J. Biol. Chem. 265:2973.PubMedGoogle Scholar
  10. 10.
    Thornhill, M., U. Kyan-Aung, T.L. Lee, and D.O. Haskard. 1990. T cells and neutrophils exhibit differential adhesion to cytokine stimulated endothelial cells. Immunology 69:287.PubMedGoogle Scholar
  11. 11.
    Bevilacqua, M.P., S. Stengelin, M.A. Gimbrone, and B. Seed. 1989. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science 243:1160.PubMedCrossRefGoogle Scholar
  12. 12.
    Picker, L.J., T.K. Kishimoto, C.W. Smith, R.A. Warnock, and E.C. Butcher. 1991. ELAM-1 is an adhesion molecule for skin-homing T cells. Nature 349:796.PubMedCrossRefGoogle Scholar
  13. 13.
    Shimizu, Y., S. Shaw, N. Graber, T.V. Gopal, K.J. Horgan, G.A. Van Seventer, and W. Newman. 1991. Activation-independent binding of human memory T cells to adhesion molecule ELAM-1. Nature 349:799.PubMedCrossRefGoogle Scholar
  14. 14.
    Osborn, L., C. Hession, R. Tizard, C. Vassallo, S. Luhowskyj, G. Chi-Rosso, and R. Lobb. 1989. Direct expression cloning of vascular cell adhesion molecule 1 (VCAM1), a cytokine-induced endothelial protein that binds to lymphocytes. Cell 59:1203.PubMedCrossRefGoogle Scholar
  15. 15.
    Yu, C.-L., D.O. Haskard, D.E. Cavender, A.R. Johnson, and M. Ziff. 1985. Human gamma inteferon increases the binding of T lymphocytes to endothelial cells. Clin. Exper. Immunol. 62:554.Google Scholar
  16. 16.
    Thornhill, M., U. Kyan-Aung, and D.O. Haskard. 1990. Interleukin-4 increases human endothelial cell adhesiveness for T cells but not for neutrophils. J. Immunol. 144:3060.PubMedGoogle Scholar
  17. 17.
    Thornhill, M.H. and D.O. Haskard. 1990. IL-4 regulates endothelial activation by IL-1, tumor necrosis factor or IFNy. J. Immunol. 145:865.PubMedGoogle Scholar
  18. 18.
    Thornhill, M., S.M. Wellicome, D.L. Mahiouz, J.S.S. Lanchbury, U. Kyan-Aung, and D.O. Haskard. 1991. Tumor necrosis factor combines with IL-4 or IFN-y to selectively enhance endothelial cell adhesiveness for T cells: the contribution of VCAM-1 dependent and independent binding mechanisms. J. Immunol. 146:592.PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1993

Authors and Affiliations

  • Dorian O. Haskard
  • Martin H. Thornhill

There are no affiliations available

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