Cytokines and the Control of Endothelial Cell Adhesiveness for Leukocytes in Inflammation
Over the last few years there has been considerable attention paid to understanding the mechanisms by which circulating leukocytes gain access to the tissues during inflammatory responses (1–3). Direct inspection of the microvasculature in inflammatory tissues has shown that leukocytes “roll” along the vessel wall before becoming flattened on the endothelial surface. Adherent leukocytes then put out pseudopodia and migrate between endothelial cells (EC) into the tissues (4–6). These events appear to be very similar at the cellular level for all types of leukocyte and depend both upon chemoattractive factors that directly activate leukocyte function and upon factors which alter the adhesive state of the endothelium. Important differences, however, may exist in the nature and regulation of endothelial ligands for leukocytes of different lineage.
KeywordsMigration Interferon Histamine Thrombin
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