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Leukocyte Interactions Mediated by P-Selection

  • Rodger P. McEver

Abstract

Endothelial cells, platelets, and leukocytes all play key roles in hemostatic and inflammatory responses to tissue injury. Many of these responses require cellular activation as well as cell-cell contact. This chapter will focus on the properties of P-selectin (CD62, formerly GMP-140 or PADGEM), a receptor that supports binding of leukocytes to activated platelets and endothelium. P-selectin-mediated adhesive interactions operate in conjunction with cell-cell interactions directed by related molecules and are likely to be important in both hemostatic and inflammatory processes.

Keywords

Sialic Acid Newcastle Disease Virus Leukocyte Adhesion Neutrophil Adhesion Lectin Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag New York Inc. 1993

Authors and Affiliations

  • Rodger P. McEver

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