Leukocyte Interactions Mediated by P-Selection

  • Rodger P. McEver


Endothelial cells, platelets, and leukocytes all play key roles in hemostatic and inflammatory responses to tissue injury. Many of these responses require cellular activation as well as cell-cell contact. This chapter will focus on the properties of P-selectin (CD62, formerly GMP-140 or PADGEM), a receptor that supports binding of leukocytes to activated platelets and endothelium. P-selectin-mediated adhesive interactions operate in conjunction with cell-cell interactions directed by related molecules and are likely to be important in both hemostatic and inflammatory processes.


Sialic Acid Newcastle Disease Virus Leukocyte Adhesion Neutrophil Adhesion Lectin Domain 
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  • Rodger P. McEver

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