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Leukocyte Interactions Mediated by P-Selection

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Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion

Abstract

Endothelial cells, platelets, and leukocytes all play key roles in hemostatic and inflammatory responses to tissue injury. Many of these responses require cellular activation as well as cell-cell contact. This chapter will focus on the properties of P-selectin (CD62, formerly GMP-140 or PADGEM), a receptor that supports binding of leukocytes to activated platelets and endothelium. P-selectin-mediated adhesive interactions operate in conjunction with cell-cell interactions directed by related molecules and are likely to be important in both hemostatic and inflammatory processes.

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Authors
  1. Rodger P. McEver
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Editors and Affiliations

  1. Internal Medicine and Microbiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX, 75235-8884, USA

    Peter E. Lipsky M.D. (Professor) (Professor)

  2. Cellular Adhesion/Immunology, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Box 368, Ridgefield, CT, 06877-0368, USA

    Robert Rothlein Ph.D. (Distinguished Scientist) & Takashi Kei Kishimoto Ph.D. (Senior Scientist) (Distinguished Scientist) &  (Senior Scientist)

  3. R&D Scientific and Technical Operations, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Box 368, Ridgefield, CT, 06877-0368, USA

    Ronald B. Faanes Ph.D. (Director) (Director)

  4. Department of Pediatrics Leukocyte Biology Section, Texas Children’s Hospital Clinical Care Center, Suite 1130 6621 Fannin, MC 3-3272, Houston, TX, 77030-2399, USA

    C. Wayne Smith Ph.D. (Professor) (Professor)

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McEver, R.P. (1993). Leukocyte Interactions Mediated by P-Selection. In: Lipsky, P.E., Rothlein, R., Kishimoto, T.K., Faanes, R.B., Smith, C.W. (eds) Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9266-8_11

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  • DOI: https://doi.org/10.1007/978-1-4613-9266-8_11

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