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Role of Inhibins and Activins in Reproduction

  • Masao Igarashi
  • Kaoru Miyamoto
  • Yoshihisa Hasegawa
  • Masaki Fukuda
  • Tsutomu Suzuki
  • Yumiko Abe
  • Masaaki Yamaguchi
  • Masaki Doi
  • Shin-Ichi Rokukawa
  • Klyoshi Tsuchiya
Part of the Serono Symposia USA Norwell, Massachusetts book series (SERONOSYMP)

Abstract

It is well established that mammalian reproduction is controlled by hypothalamic, pituitary, and gonadal hormones. Until recent years, steroid hormones had been considered the only known gonadal hormones. However, recent progress in endocrinology has begun to clarify the fact that nonsteroidal gonadal factors play an important role in reproduction. Among these nonsteroidal gonadal factors, inhibin and activin are the most important.

Keywords

Granulosa Cell Corpus Luteum Follicular Fluid Activin Receptor Serum Inhibin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Mottram JC, Cramer W. On the general effects of exposure to radium on metabolism and tumour growth in the rat and the special effects on testis and pituitary. Q J Exp Physiol 1923;13:209–29.Google Scholar
  2. 2.
    McCullagh DR. Dual endocrine activity of the testis. Science 1932;76:19–20.PubMedCrossRefGoogle Scholar
  3. 3.
    Miyamoto K, Fukuda M, Nomura M, et al. Isolation of porcine follicular inhibin of 32K daltons. Biochem Biophys Res Commun 1985;129:396–403.PubMedCrossRefGoogle Scholar
  4. 4.
    Robertson DM, Foulds LM, Levershall L, et al. Isolation of inhibin from bovine follicular fluid. Biochem Biophys Res Commun 1985;126:220–6.PubMedCrossRefGoogle Scholar
  5. 5.
    Ling N, Ying SY, Ueno N, Esch F, Denoroy L, Guillemin R. Isolation and partial characterization of a Mr 32,000 protein with inhibin activity from porcine follicular fluid. Proc Natl Acad Sci USA 1985;82:7217–21.PubMedCrossRefGoogle Scholar
  6. 6.
    de Jong FH, Sharpe RM, Evidence for inhibin-like activity in bovine follicular fluid. Nature 1976;263:71–2.PubMedCrossRefGoogle Scholar
  7. 7.
    Fukuda M, Miyamoto K, Hasegawa Y, et al. Isolation of bovine follicular fluid inhibin of about 32KDa. Mol Cell Endocrinol 1986;44:55–60.PubMedCrossRefGoogle Scholar
  8. 8.
    Suzuki T, Miyamoto K, Hasegawa Y, et al. Regulation of inhibin production by rat granulosa cells. Mol Cell Endocrinol 1987;54:185–95.PubMedCrossRefGoogle Scholar
  9. 9.
    Fukuda M, Miyamoto K, Hasegawa Y, Ibuki Y, Igarashi M. Action mechanism of inhibin in vitro-cycloheximide mimics inhibin actions on pituitary cells. Mol Cell Endocrinol 1987;51:41–50.PubMedCrossRefGoogle Scholar
  10. 10.
    Hasegawa Y, Miyamoto K, Fukuda M, Takahashi Y, Igarashi M. Immunological studies of ovarian inhibin. Endocrinol Jpn 1986;33:645–54.PubMedCrossRefGoogle Scholar
  11. 11.
    Hasegawa Y, Miyamoto K, Igarashi M, Yanaka T, Sasaki K, Iwamura S. Changes in serum concentrations of inhibin during the estrous cycle of the rat, pig and cow. In: Burger HG, deKretser DM, Findlay JK, Igarashi M, eds. Inhibin-non-steroidal regulation of follicle stimulating hormone secretion. Serono Symposia Publications. New York: Raven Press, 1988;42:119–33.Google Scholar
  12. 12.
    Hasegawa Y. Changes in the serum concentrations of inhibin in mammals. In: Hodgen GD, Rosenwaks Z, Spieler JM, eds. Nonsteroidal gonadal factors; physiological roles and possibilities in contraceptive development. Proc Conrad Int Workshop, Jan 6–8, 1988. Norfolk: Jones Institute Press, 1988: 91–109.Google Scholar
  13. 13.
    Hamada T, Watanabe A, Kokuho T, et al. Radioimmunoassay of inhibin in various mammals. J Endocrinol 1989;122:697–704.PubMedCrossRefGoogle Scholar
  14. 14.
    Hasegawa Y, Miyamoto K, Iwamura S, Igarashi M. Changes in serum concentrations of inhibin in cycle pigs. J Endocrinol 1988;118:211–9.PubMedCrossRefGoogle Scholar
  15. 15.
    Hasegawa Y, Miyamoto K, Igarashi M. Changes in serum concentrations of immunoreactive inhibin during the oestrous cycle of the rat. J Endocrinol 1989;121:91–100.PubMedCrossRefGoogle Scholar
  16. 16.
    Hasegawa Y, Miyamoto K, Kudoh T, et al. Changes in serum concentrations of inhibin during the menstrual cycles of women [Abstract]. Proc 8th Int Cong Endocrinol 1988:138.Google Scholar
  17. 17.
    Tsuchiya K, Hasegawa Y, Seki M, Miyamoto K, Ito M, Igarashi M. Correlation of serum inhibin concentrations with results in an ovarian hyper-stimulation program. Fertil Steril 1989;52:1–7.Google Scholar
  18. 18.
    Yamaguchi M, Mizunuma H, Miyamoto K, Hasegawa Y, Ibuki Y, Igarashi M. Immunoreactive inhibin concentration in adult men: presence of a circadian rhythm. J Clin Endocrinol Metab 1991;72:554–9.PubMedCrossRefGoogle Scholar
  19. 19.
    Abe Y, Hasegawa Y, Miyamoto K, et al. High concentrations of plasma immunoreactive inhibin during normal pregnancy in women. J Clin Endocrinol Metab 1990;71:133–7.PubMedCrossRefGoogle Scholar
  20. 20.
    Vale W, Rivier J, Vaughan J, et al. Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid. Nature 1986; 321:776–9.PubMedCrossRefGoogle Scholar
  21. 21.
    Ling N, Ying SY, Ueno N, et al. Pituitary FSH is released by a heterodimer of the ² subunits from the two forms of inhibin. Nature 1986;321:779–82.PubMedCrossRefGoogle Scholar
  22. 22.
    Burger HG, deKretser DM, Findlay JK, Igarashi M. Inhibin-non-steroidal regulation of follicle stimulating hormone seeretion. Serono Symposia Publications. New York: Raven Press, 1982:42.Google Scholar
  23. 23.
    Eto Y, Tsuji T, Takezawa M, Takano S, Yakagawa Y, Shibai H. Purification and characterization of erythroid differentiation factor (EDF) isolated from human leukemia cell THP-1. Biochem Biophys Res Commun 1987;142:1095–103.PubMedCrossRefGoogle Scholar
  24. 24.
    Kitaoka M, Yamashita N, Eto Y, Shibai H, Ogata E. Stimulation of FSH release by erythroid differentiation factor (EDF). Biochem Biophys Res Commun 1987;146:1382–5.PubMedCrossRefGoogle Scholar
  25. 25.
    Miyamoto K, Hasegawa Y, Fukuda M, Igarashi M. Structure and function of inhibin and its related peptides. In: Hodgen DG, Rosenwaks Z, Spieler JM, eds. Nonsteroidal gonadal factors; physiological roles and possibilities in contraceptive development. Proc Conrad Int Workshop, Jan 6–8, 1988. Norfolk: Jones Institute Press, 1988:56–73.Google Scholar
  26. 26.
    Hasegawa Y. Production and function of inhibin and its related peptides. Jpn J Anim Reprod 1988;34:1–7.Google Scholar
  27. 27.
    Sugino T, Nakamura T, Hasegawa Y, et al. Identification of a specific receptor for erythroid differentiation factor on follicular granulosa cell. J Biol Chem 1988;26330:15249–52.Google Scholar
  28. 28.
    Hasegawa Y, Miyamoto K, Abe Y, et al. Induction of follicle stimulating hormone receptor by erythroid differentiation factor on rat granulosa cell. Biochem Biophys Res Commun 1988;156:668–74.PubMedCrossRefGoogle Scholar
  29. 29.
    Sugino H, Nakamura T, Hasegawa Y, et al. Erythroid differentiation factor can modulate follicular granulosa cell functions. Biochem Biophys Res Commun 1988;153:281–8.PubMedCrossRefGoogle Scholar
  30. 30.
    Itoh M, Igarashi M, Yamada K, et al. Activin A stimulates meiotic maturation of rat oocyte in vitro. Biochem Biophys Res Commun 1990;166:1479–84.PubMedCrossRefGoogle Scholar
  31. 31.
    Woodruff TK, Lyon RJ, Hasen SE, Rice GC, Mather JP. Inhibin and activin locally regulate rat ovarian folliculogenesis. Endocrinology 1990;127:3196–205.PubMedCrossRefGoogle Scholar
  32. 32.
    Rokukawa S, Inoue K, Miyamoto K, Kurosumi K, Igarashi M. Immuno-histochemical localization of inhibin in porcine and bovine ovaries. Arch Histol Jpn 1986;49:603–11.PubMedCrossRefGoogle Scholar
  33. 33.
    Vale W, Rivier C, Hsueh A, et al. Chemical and biological characterization of the inhibin family of protein hormones. Recent Prog Horm Res 1988;44:1–34.PubMedGoogle Scholar
  34. 34.
    Kitaoka M, Kojima I, Ogata E. A stimulatory effect of somatostatin: enhancement of activin A-mediated FSH secretion in rat pituitary cell. Biochem Biophys Res Commun 1989;162:958–62.PubMedCrossRefGoogle Scholar
  35. 35.
    Kitaoka M, Kojima I, Ogata E. Activin-A: a modulator of multiple types of anterior pituitary cells. Biochem Biophys Res Commun 1988;157:48–54.PubMedCrossRefGoogle Scholar
  36. 36.
    Billestrup N, Gouzalez-Manchon C, Potter E, Vale W. Inhibition of somatotroph growth and growth hormone biosynthesis by activin in vitro. Mol Endocrinol 1990;4:356–62.PubMedCrossRefGoogle Scholar
  37. 37.
    Bileszikjian LM, Corrigan AZ, Vale W. Activin A modulates growth hormone secretion from cultures of rat anterior pituitary cells. Endocrinology 1990;126:2369–76.CrossRefGoogle Scholar
  38. 38.
    Mine T, Kojima I, Ogata E. Stimulation of glucose production by activin-A in isolated rat hepatocytes. Endocrinology 1989;125:586–91.PubMedCrossRefGoogle Scholar
  39. 39.
    Totsuka Y, Tabuchi M, Kojima I, Shibai H, Ogata E. A novel action of activin A: stimulation of insulin secretion in rat pancreatic islets. Biochem Biophys Res Commun 1988;156:335–9.PubMedCrossRefGoogle Scholar
  40. 40.
    Schwall R, Schmelzer CH, Matsuyama E, Mason AJ. Multiple actions of recombinant activin-A in vivo. Endocrinology 1989;125:1420–3.PubMedCrossRefGoogle Scholar
  41. 41.
    Schubert D, Kimura H, La Corbiere M, Vaughan J, Karr D, Fisher WH. Activin is a nerve cell survival molecule. Nature 1990;344:868–70.PubMedCrossRefGoogle Scholar
  42. 42.
    Hashimoto M, Kondo S, Sakurai T, Eto Y, Shibai H, Muramatsu M. Activin/EDF as an inhibitor of neural differentiation. Biochem Biophys Res Commun 1990;173:193–200.PubMedCrossRefGoogle Scholar
  43. 43.
    Sawchenko PE, Plotsky PM, Pfeiffer SW, et al. Inhibin β in central neural pathways involved in the control of oxytocin secretion. Nature 1988;334: 615–7.PubMedCrossRefGoogle Scholar
  44. 44.
    Spencer SJ, Rabinovici J, Jaffe RB. Human recombinant activin A inhibits proliferation of human fetal adrenal cells in vitro. J Clin Endocrinol Metab 1990;71:1678–80.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1993

Authors and Affiliations

  • Masao Igarashi
  • Kaoru Miyamoto
  • Yoshihisa Hasegawa
  • Masaki Fukuda
  • Tsutomu Suzuki
  • Yumiko Abe
  • Masaaki Yamaguchi
  • Masaki Doi
  • Shin-Ichi Rokukawa
  • Klyoshi Tsuchiya

There are no affiliations available

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