Abstract
Cancer of the ovary is the leading cause of death from gynecologic cancer. Early diagnosis is a matter of chance rather than a scientific approach. The inability to diagnose ovarian cancer is evident from reports showing that 60 to 70% of these lesions are in stages III and IV at the time of diagnosis. The physician must have a high index of suspicion, use any and all clues, and evaluate an enlarged ovary regardless of the patient’s age. Our chances for improving the low 5-year survival would be immeasurably better if we could find ways to make an early diagnosis or diagnose the borderline or potentially malignant cases. The means for diagnosis are nonspecific but are reviewed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Bibliography
Abelev GI: Alpha fetoprotein in oncogenesis and its association with malignant tumors. Adv Cancer Res 14: 295, 1971.
Alexander P: Fetal “antigens” in cancer. Nature 235: 137, 1972.
Alpert ME, Uriel J, DeNechaud B: Alpha fetoglobulin in the diagnosis of human hepatoma. N Engl J Med 278: 964, 1966.
Bagley CM Jr, Young RC, Schein PS, et al: Ovarian carcinoma metastatic to the diaphragm— frequently undiagnosed at laparotomy: a preliminary report. Am J Obstet Gynecol 116: 397, 1973.
Bagley CM Jr, Young RC, Canelos GP, et al: Treatment of ovarian cancer: possibilities for progress. N Engl J Med 287: 856, 1972.
Baldwin RW: Tumor-specific antigens associated with chemically induced tumors. Rev Eur Etud Clin Biol 25: 593, 1970.
Baldwin RW, Erubleton MJ: Demonstration by colony inhibition methods of cellular and humoral immune reactions to tumor-specific antigens associated with aminoazo-dye-induced rat hepatomas. Int J Cancer 7: 17, 1971.
Barber HRK: A new test for ovarian cancer? Female Patient 15: 11, 1990.
Barber HRK (ed): Immunobiology for the Clinician. Wiley, New York, 1977.
Barber HRK: Surgical management of ovarian cancer. Curr Obstet Gynecol Tech 1: 6, 1975.
Barber HRK, Graber EA: Surgical aspects of ovarian tumors. In: Selected Topics of Cancer Current Concepts. Symposia Specialists, Miami, 1974, p. 161.
Barber HRK, Graber EA, Kwon T: Ovarian Cancer. Professional Education Publication. American Cancer Society, Atlanta, 1974, p. 2.
Coligan JE, Eagan ML, Todd CW: Detection of carcinoembryonic antigen by radioimmune assay. Natl Cancer Inst Monogr 35: 427, 1972.
Collins WP: Transvaginal color flow imaging: a possible new screening technique for ovarian cancer. Br Med J 299: 1367, 1989.
Donald I: Diagnostic uses of sonar in obstetrics and gynecology. J Obstet Gynecol Br Commonw 72: 907, 1965.
Donald I: New problems in sonar diagnosis in obstetrics and gynecology. Am J Obstet Gynecol 118: 299, 1974.
Donald I, MacVicar J, Brown TG: Investigation of abdominal masses by pulsal ultrasound. Lancet 1: 1188, 1958.
Edynak EM, Hirshant Y, Old LJ, Trempe GL: Antigens of human breast cancer. Proc Am Assoc Cancer Res 12: 75, 1971.
Fleischer AC, Zaleski WM, Kepple DM: Abdominal and pelvic applications of color Doppler sonography. Toshiba Med Rev 30: 37, 1989.
Fleischer AC, Rao BK, Kepple DM: Transvaginal color doppler sonography: preliminary experiences. Dynamic Cardiovascular Imaging 3: 52, 1990.
Gaylord GM, Davis LP, Baker SR: Diagnostic and Interventional Radiology: A Clinical Manual. Saunders, Philadelphia, 1989.
Graber EA: Early diagnosis of ovarian malignancy. Clin Obstet Gynecol 12: 958, 1969.
Gusberg SB, Frick HC II: Corscaden’s Gynecologic Cancer. Wilhams & Wilkins, Baltimore, 1970.
Haber E: Radioimmunoassay—Principles and Practical Applications. Little, Brown, Boston, 1974.
Hassani SN (ed): Ultrasound in Gynecology and Obstetrics (in collaboration with Bard RL). Springer-Verlag, New York, 1978, p. 12.
Ioachim HL, Dorsett BH, Sabbath M, et al: Antigenic and morphologic properties of ovarian carcinoma. Gynecol Oncol 1: 130, 1973.
Kobayashi T, Osamutakantani HN: Echographic evaluation of abdominal tumor regressing during antineoplastic treatment. J Clin Ultrasound 2: 131, 1974.
Kremkau FW: Doppler instruments. In: Diagnostic Ultrasound. Saunders, Philadelphia, 1988, pp. 177–197.
Laurence DJR, Munro N: Fetal antigens and their role in diagnosis and clinical management of human neoplasms: a review. Br J Cancer 26: 335, 1972.
Laurora J, Jandora A, Skoda A, et al: Verhalten des Immunoglobulinspiegels in Blutserum ber Patientinsan mit Carcinoma Ovarii. Zentralbl Gynakol 97: 540, 1975.
Leopold GR, Asher WM: Ultrasound in obstetrics and gynecology. Radiol Clin North Am 12: 127, 1974.
LoGerfo P, Krupey J, Hansen HJ: Demonstration of antigen common to several varieties of neoplasia. N Engl J Med 283: 138, 1971.
McGowan L: Peritoneal fluid profiles: symposium on ovarian carcinoma. Natl Cancer Inst Monogr 42: 75, 1975.
McGowan L, Stein DB, Miller W: Cul-de-sac aspiration for diagnostic cytologic study. Am J Obstet Gynecol 96: 413, 1966.
Melnick H, Barber HRK: Cellular immunologic responsiveness to extracts of ovarian epithelial tumors. Gynecol Oncol 3: 77, 1975.
Meyers MA: The spread and localization of acute intraperitoneal effusions. Radiology 95: 547, 1970.
Mitchison NA: Immunologic approaches to cancer. Transplant Proc 2: 92, 1970.
Richart RM, Fenoglio CM: Principles of diagnosis. In Gusberg SB, Frick HC II (eds): Corscaden’s Gynecologic Cancer. 5th Ed. Williams & Wilkins, Baltimore, 1978, p. 24.
Rosenoff SH, DeVita VT Jr, Hubbard S, Young RC: Peritoneoscopy in the staging and followup of ovarian cancer. Semin Oncol 2: 223, 1975.
Rosenoff SH, Young RC, Anderson T, et al: Peritoneoscopy: a valuable tool for the initial staging and “second look” in ovarian carcinoma. Ann Intern Med 83: 37, 1975.
Samuels BI: Usefulness of ultrasound in patients with ovarian cancer. Semin Oncol 2: 229, 1975.
Shuster J: Immunologic diagnosis of human cancers. Am J Clin Pathol 62: 243, 1974.
Stolbach LL, Krant MJ, Fishman WH: Ectopic production of an alkaline phosphatase isoenzyme in patients with cancer. N Engl J Med 281: 757, 1969.
Straub WH (ed): Manual of Diagnostic Surgery. Little, Brown, Boston, 1989.
Thaler I, Brack A, Bar-Yann Y: The vaginal probe—physical considerations. In Timor-Tritsch IE, Rottem S (eds): Transvaginal Sonography. Elsevier, New York, 1988, pp. 1–15.
Updated guide to diagnostic ultrasound. Contemp Obstet Gynecol 3: 105, 1974.
Van Nagell JR, Meeker WR, Parker JC Jr, Harralson JD: Carcinoembryonic antigen in patients with gynecologic malignancy. Cancer 35: 1372, 1975.
Young RC, Hubbard SP, DeVita VT: The chemotherapy of ovarian cancer. Cancer Treat Rev 1: 99, 1974.
Zemlyn S: Comparison of pelvic ultrasonography and pneumography for ovarian size. Clin Ultrasound 2: 331, 1974.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag New York, Inc.
About this chapter
Cite this chapter
Barber, H.R.K. (1993). Diagnostic Evaluation and Preoperative Work-up. In: Ovarian Carcinoma. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9232-3_8
Download citation
DOI: https://doi.org/10.1007/978-1-4613-9232-3_8
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4613-9234-7
Online ISBN: 978-1-4613-9232-3
eBook Packages: Springer Book Archive