According to Decker and coworkers, within a given stage of ovarian epithelial carcinoma, regardless of the histologic cell type, the increasingly higher grades have an increasingly poorer prognosis. This finding suggests that more intensive therapy be considered for all patients with ovarian epithelial carcinomas than is currently undertaken. Decker also restated that epithelial ovarian cancer has always been difficult to treat successfully. The concept of a “scale of malignancy” was suggested by Virchow as long ago as 1858, but its application to ovarian carcinoma classification systems has not been implemented. Reports by Decker have demonstrated the value of grading tumors for prognostic significance, and the International Federation of Gynecology and Obstetrics (FIGO) has now recognized that grading has value in the classification of carcinoma of the endometrium. It is anticipated that increased attention will be directed to the grading of ovarian cancers. Barber and associates reported on histologic and nuclear grading and stromal reactions as indices for prognosis in ovarian cancer. That report provides the basis for this chapter.
KeywordsOvarian Cancer Plasma Cell Histologic Grade Ovarian Carcinoma Epithelial Ovarian Cancer
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