Ovarian cancer often resembles an autoimmune disorder. These patients may be difficult to cross-match, and it has been observed that they have an antibody that interferes with cross-matching. Such an antibody, which may occur in patients who have not been transfused, reacts against normal tissue but does not recognize the ovarian cancer antigen. It can be suppressed after cortisone treatment. For 2 to 3 days following this therapy it is possible to cross-match the patient. In addition, the use of anticancer drug treatment gives the patient a sense of well-being long before there is any effect on tumor volume. These observations are suggestive but not conclusive that an autoimmune disorder results from the ovarian cancer.
KeywordsOvarian Cancer Immune Complex Recurrent Ovarian Cancer Primary Immunodeficiency Disease DiGeorge Syndrome
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