Skip to main content

Progress towards Peptide Vaccines for Foot-and-Mouth Disease

  • Chapter

Part of the book series: Progress in Vaccinology ((VACCINOLOGY,volume 4))

Abstract

Despite the impressive advances that have been made in recent years in our understanding of the mechanisms of immune responses to pathogenic organisms and the antigenic and chemical structures of the organisms themselves, these have yet to result in the widescale introduction of novel vaccines. In both veterinary and human fields the vaccines in use today are basically similar to those developed at the dawn of the era of vaccination and fall into two groups: killed vaccines, in which the virulent pathogen is rendered innocuous by chemical or physical inactivation, and attenuated vaccines, in which the virulence of the pathogen is reduced by laboratory culture in a largely empirical fashion. One exception is the surface antigen vaccine against hepatitis B virus, which is expressed in yeast and is the only practical vaccine to have emerged so far from the application of recombinant DNA techniques (57).

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Acharya R, Fry E, Stuart D, et al: The three dimensional structure of foot and mouth disease virus at 2.9 A resolution. Nature (London) 1989; 327: 709–716.

    Article  Google Scholar 

  2. Adams SE, Dawson KM, Gull K, et al: The expression of hybrid HIV: Ty virus like particles in yeast. Nature (London) 1987; 329: 68–70.

    Article  CAS  Google Scholar 

  3. Amit AG, Maruizza RA, Phillips SEV, Poljak RJ: Three dimensional structure of antigen antibody complex at 6 A. Nature (London) 1985; 313: 156–158.

    Article  CAS  Google Scholar 

  4. Argos P, Fuller SD: A model for the hepatitis B core protein: prediction of antigenic sites and relationship to RNA virus capsid proteins. EMBO J 1988; 7: 819.

    PubMed  CAS  Google Scholar 

  5. Bachrach HL, Moore DM, McKercher PD, Polatnick J: Immune and antibody responses to an isolated capsid protein of foot and mouth disease virus. J Immunol 1975; 115: 1636–1641.

    PubMed  CAS  Google Scholar 

  6. Barnett PV, Ouldridge EJ, Rowlands DJ, et al: Neutralizing epitopes of type 0 foot and mouth disease virus. I: Identification and characterization of three functionally independent, conformational sites. J Gen Virol 1989; 70: 1483–1491.

    Article  PubMed  CAS  Google Scholar 

  7. Baxt B, Becker Y: The effect of peptides containing the arginine-glycineaspartic acid sequence on the adsorption of foot and mouth disease virus to tissue culture cells. Virus Genes 1990; 4: 73–83.

    Article  PubMed  CAS  Google Scholar 

  8. Beck E, Strohmaier K: Subtyping of European foot and mouth disease virus strains by nucleotide sequence determination. J Virol 1987; 61: 1621.

    PubMed  CAS  Google Scholar 

  9. Bittle JL, Houghten RA, Alexander H, et al: Protection against foot and mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence. Nature (London) 1982; 298: 30–33.

    Article  CAS  Google Scholar 

  10. Bolwell C, Brown AL, Barnett PV, et al: Host cell selection of antigenic variants of foot and mouth disease virus. J Gen Virol 1989; 70: 45–57.

    Article  PubMed  CAS  Google Scholar 

  11. Bolwell C, Clarke BE, Parry NR, et al: Epitope mapping of foot and mouth disease virus with neutralizing monoclonal antibodies. J Gen Virol 1989; 70: 59–68.

    Article  PubMed  CAS  Google Scholar 

  12. Borras-Cuesta F, Petit-Camurdan A, Fedan Y: Engineering of immunogenic peptides by co-linear synthesis of determinants recognised by B and T cells. Eur J Immunol 1987; 17: 1214–1216.

    Article  Google Scholar 

  13. Broekhuijsen MP, Van Rijn JMM, Blom AJM, et al: Fusion proteins with multiple copies of the major antigenic determinant of foot and mouth disease virus protect both the natural host and laboratory animals. J Gen Virol 1987; 68: 3157–3143.

    Article  Google Scholar 

  14. Brooksby JT: Portraits of viruses: Foot and mouth disease virus. Intervirology 1982; 18: 1–23.

    Article  PubMed  CAS  Google Scholar 

  15. Brown AL, Francis MJ, Hastings GZ, et al: Foreign epitopes in immunodominant regions of hepatitis B core particles are highly immunogenic and conformationally restricted. Vaccine 1991; 9: 595–601.

    Article  PubMed  CAS  Google Scholar 

  16. Brown F: The development of chemically synthesised vaccines. Adv Vet Sci Comp Med 1989; 33: 173–193.

    PubMed  CAS  Google Scholar 

  17. Brown F, Smale CJ: Demonstration of three specific sites on the surface of foot and mouth disease virus. J Gen Virol 1970; 7: 115.

    Article  PubMed  CAS  Google Scholar 

  18. Brown F, Stewart DL: The influence of proflavine on the synthesis of the foot and mouth disease virus. J Gen Microbiol 1960; 23: 369–379.

    CAS  Google Scholar 

  19. Brown F, Wild TF: The effect of heat on the structure of foot and mouth disease virus and the viral ribonucleic acid. Biochim Biophys Acta 1966; 119: 301–308.

    PubMed  CAS  Google Scholar 

  20. Burke KL, Dunn G, Ferguson M, et al: Antigen chimeras of poliovirus as potential new vaccines. Nature (London) 1988; 332: 81–82.

    Article  CAS  Google Scholar 

  21. Burroughs JN, Rowlands DJ, Sangar DV, et al: Further evidence for multiple proteins in the foot and mouth disease virus particle. J Gen Virol 1971; 13: 73–84.

    Article  PubMed  CAS  Google Scholar 

  22. Capstick PB, Telling RC, Chapman RC, Stewart DL: Growth of a cloned strain of hamster kidney cells in suspended culture and their susceptibility to the virus of foot and mouth disease. Nature (London) 1962; 195: 1163.

    Article  CAS  Google Scholar 

  23. Clarke BE, Brown AL, Grace KG, et al: Presentation and Immunogenicity of viral epitopes on the surface of hybrid hepatitis B virus core particles produced in bacteria. J Gen Virol 1990; 71: 1109–1117.

    Article  PubMed  CAS  Google Scholar 

  24. Clarke BE, Carroll AR, Brown AL, et al: Expression and immunological analysis of hepatitis B core fusion particles carrying internal heterologous sequences. In: Chanock RM, Ginsberg HS, Brown F, Lerner RA (eds): Vaccines 91. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1991, pp 313–318.

    Google Scholar 

  25. Clarke BE, Newton SF, Carroll AR, et al: Improved immunogenicity of a peptide epitope after fusion to hepatitis B core protein. Nature (London) 1987; 330: 381–384.

    Article  CAS  Google Scholar 

  26. Collin T, DiMarchi R, Doel TR: A T cell epitope in VP1 of foot and mouth disease virus is immunodominant for vaccinated cattle. J Immunol 1991; 146: 749–755.

    Google Scholar 

  27. Delpeyroux F, Chenciner N, Lim A, et al: A poliovirus neutralization epitope expressed on hybrid hepatitis B surface antigen particles. Science 1986; 233: 472–475.

    Article  PubMed  CAS  Google Scholar 

  28. Denoya CD, Scodeller EA, Vasquez C, La Torre JA: Foot and mouth disease virus: Endoribonuclease activity within purified virions. Virology 1978; 89: 67–74.

    Article  PubMed  CAS  Google Scholar 

  29. Di Marchi R, Brooke G, Gale C, et al: Protection of cattle against foot and mouth disease by a synthetic peptide. Science 1986; 232: 639–641.

    Article  Google Scholar 

  30. Donaldson AI, Gloster J, Harvey LDJ, Deans DH: Use of prediction models to forecast and analyse airborne spread during the foot and mouth disease outbreak in Britany, Jersey and the Isle of Wight in 1981. Vet Rec 1982; 110: 53–57.

    Article  PubMed  CAS  Google Scholar 

  31. Duke GM, Osorio JE, Palmenberg AC: Attenuation of Mengo virus through genetic engineering of the 5’ non coding poly (C) tract. Nature (London) 1990; 343: 474–476.

    Article  CAS  Google Scholar 

  32. Fox G, Parry NR, Barnett PV, et al: The cell attachment site on foot and mouth disease virus includes the amino acid sequence RGD (arginine-glycineaspartic acid). J Gen Virol 1989; 70: 625–637.

    Article  PubMed  CAS  Google Scholar 

  33. Fracastorius H: De Contagione et Contagiosis Morbis et Curatione. Book 1, Chapter 12, L.A. Junta, Venice 1546.

    Google Scholar 

  34. Francis MJ, Clarke BE: Peptide vaccines based on enhanced immunogenicity of peptide epitopes presented with T cell determinants or hepatitis B core protein. Methods Enzymol 1989; 178: 659.

    Article  PubMed  CAS  Google Scholar 

  35. Francis MJ, Fry CM, Rowlands DJ, Brown F: Qualitative and quantitative differences in the immune response to foot and mouth disease virus antigens and synthetic peptides. J Gen Virol 1988; 69: 2483–2491.

    Article  PubMed  CAS  Google Scholar 

  36. Francis MJ, Fry CM, Rowlands DJ, et al: Immunological priming with synthetic peptides of foot and mouth disease virus. J Gen Virol 1985; 66: 2437–2354.

    Article  Google Scholar 

  37. Francis MJ, Fry CM, Rowlands DJ, et al: Immune response to uncoupled peptides of foot and mouth disease virus. Immunology 1987; 61: 1–6.

    PubMed  CAS  Google Scholar 

  38. Francis MJ, Hastings GZ, Brown AL, et al: Immunological properties of hepatitis B core antigen fusion proteins. Proc Nati Acad Sci USA 1990; 87: 2545–2549.

    Article  CAS  Google Scholar 

  39. Francis MJ, Hastings GZ, Clarke BE, et al: Neutralizing antibodies to all seven serotypes of foot and mouth disease virus elicited by synthetic peptides. Immunol 1990; 69: 171–176.

    CAS  Google Scholar 

  40. Francis MJ, Hastings GZ, Sangar, DV, et al: A synthetic peptide which elicits neutralizating antibody against human rhinovirus type 2. J Gen Virol 1987; 68: 2687–2691.

    Article  PubMed  CAS  Google Scholar 

  41. Francis Mil, Hastings GZ, Syred AD, et al: Non responsiveness to a foot and mouth disease virus peptide overcome by addition of foreign helper T cell determinants. Nature (London) 1987; 330: 168–170.

    Article  CAS  Google Scholar 

  42. Frenkel HS: La culture du virus de la fleure aphteuse sur l’ epithelium de la langue des bovides. Bull Off Int Epizcot 1947; 28: 155.

    Google Scholar 

  43. Getzoff ED, Tainer JA, Lerner RA, Geysen HM: The chemistry and mechanism of antibody binding to protein antigens. Adv Immunol 1989; 43: 1–97.

    Article  Google Scholar 

  44. Geyson HM, Meloen RH, Barteling SJ: Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid. Proc Natl Acad Sci USA 1984; 81: 3998–4002.

    Article  Google Scholar 

  45. Gloster J, Sellars RF, Donaldson AI: Long distance transport of foot and mouth disease virus over the sea. Vet Rec 1982; 110: 47–52.

    Article  PubMed  CAS  Google Scholar 

  46. Good MF, Maloy WL, Lunde MN, et al: Construction of synthetic immunogen: use of new T-helper epitope on malaria circumsporozoite protein. Science 1987; 235: 1059–1062.

    Article  PubMed  CAS  Google Scholar 

  47. Harris TJM, Brown F: Biochemical analysis of a virulent and an avirulent strain of foot and mouth disease virus. J Gen Virol 1977; 34: 87.

    Article  PubMed  CAS  Google Scholar 

  48. Hilditch CM, Rogers LJ, Bishop DHL: Physicochemical analysis of the hepatitis B virus core antigen produced by a baculovirus expression vector. J Gen Virol 1990; 71: 2755–2759.

    Article  PubMed  CAS  Google Scholar 

  49. Hogle JM, Chow M, Filman DJ: The three dimensional structure of poliovirus at 2.9A resolution. Science 1985; 229: 1358–1365.

    Article  PubMed  CAS  Google Scholar 

  50. Kim S, Smith TJ, Chapman MS, et al: Crystal structure of human rhinovirus serotype lA (HRV1A). J Mol Biol 1989; 210: 91–111.

    Article  PubMed  CAS  Google Scholar 

  51. King AMQ, Underwood BO, McCahon D, et al: Biochemical identification of viruses causing the 1981 outbreak of foot and mouth disease in the UK. Nature (London) 1981; 293: 497.

    Article  Google Scholar 

  52. Kleid DJ, Yansura D, Small B, et al: Cloned viral protein vaccine for foot and mouth disease; response in cattle and swine. Science 1981; 214: 1125.

    Article  PubMed  CAS  Google Scholar 

  53. Kurz C, Forss C, Kupper H, et al: Nucleotide sequence and corresponding amino acid sequence of the gene for the major antigen of foot and mouth disease virus. Nucl Acids Res 1981; 9: 1919–1931.

    Article  PubMed  CAS  Google Scholar 

  54. Laporte J, Crosclaude J, Wantyghem J, et al: Neutralisation en culture cellulaire du pouvoir infectieux du virus de la fievre aphteuse par des serums provenent de porcs immunises a l’aide d’une proteine virale purifiee. CR Hebd Seanc Acad Sci Paris 1973; 276: 3399.

    CAS  Google Scholar 

  55. Leclerc C, Przewlocki G, Schutze MP, Chedid L: (1987). A synthetic vaccine constructed by co-polymerization of B and T cell determinants. Eur J Immunol 1987; 17: 269–273.

    Article  Google Scholar 

  56. Luo M, Vriend G, Kamer G, et ai: The atomic structure of Mengo virus at 3.0 A resolution. Science 1987; 235: 182–191.

    Article  PubMed  CAS  Google Scholar 

  57. Mateu MG, Martinez MA, Capucci L, et al: A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot and mouth disease virus of serotype C. J Gen Virol 1990; 71: 629637.

    Google Scholar 

  58. McAleer WJ, Bunyak EB, Maigetter RR, et al: Human hepatitis B vaccine from recombinant yeast. Nature (London) 1984; 305: 178–180.

    Article  Google Scholar 

  59. McCahon D, Crowther JR, Belsham GJ, et al: Evidence for at least four antigenic sites on type 0 foot and mouth disease virus involved in neutralization; identification by single and multiple site monoclonal antibody resistant mutants. J Gen Virol 1989; 70: 639–645.

    Article  PubMed  CAS  Google Scholar 

  60. Meloen RH, Rowlands DJ, Brown F: Comparison of the antibodies elicited by the individual structural polypeptides of foot and mouth disease and polioviruses. J Gen Virol 1979; 45: 761–763.

    Article  PubMed  CAS  Google Scholar 

  61. Milich DR, McLachlan A, Moriarty A, Thornton G: Immune response to hepatitis B core antigen (HBcAg); localisation of T cell recognition sites within HBcAg/HBeAg. J Immunol 1987; 139: 1223–1231.

    PubMed  CAS  Google Scholar 

  62. Morgan DO, Moore DM: Protection of cattle and swine against foot and mouth disease using biosynthetic peptide vaccines. Am J Vet Res 1990; 51: 40–45.

    PubMed  CAS  Google Scholar 

  63. Mucahy G, Gale C, Robertson P, et al: Isotype responses of infected, virus-vaccinated and peptide-vaccinated cattle to foot-and-mouth disease virus. Vaccine 1990; 8: 249–256.

    Article  Google Scholar 

  64. Palmenberg AC: Sequence alignments of picornaviral capsid proteins. In: Semler BL, Ehrenfeld E (eds): Molecular Aspects of Picornavirus Infection and Detection. Washington, DC: American Society for Microbiology, 1989, pp 211–241.

    Google Scholar 

  65. Parry NR, Barnett PV, Ouldridge EJ, et al: Neutralizing epitopes of type 0 foot and mouth disease virus. II Mapping three conformational sites with synthetic peptide reagents. J Gen Virol 1989; 70: 1493–1503.

    Article  PubMed  CAS  Google Scholar 

  66. Parry NR, Fox G, Rowlands DJ, et al: Strucutral and serological evidence for a novel mechanism of antigenic variation in foot and mouth disease virus. Nature (London) 1990; 347: 569–572.

    Article  CAS  Google Scholar 

  67. Parry NR, Ouldridge EJ, Barnet PV, et al: Serological prospects for peptide vaccines against foot and mouth disease virus. J Gen Virol 1989; 70: 2919 2930.

    Google Scholar 

  68. Parry NR, Syred A, Rowlands DJ, Brown F: A high proportion of antipeptide antibodies recognise foot and mouth disease virus particles. Immunology 1998; 64: 567–572.

    Google Scholar 

  69. Pfaff E, Mussgay HO, Schulz GE, Schaller H: Antibodies against a preselected peptide recognise and neutralize foot and mouth disease virus. EMBO J 1982; 1: 869.

    PubMed  CAS  Google Scholar 

  70. Pfaff E, Thiel HJ, Beck E, et al: Analysis of neutralizing epitopes on foot and mouth disease virus. J Virol 1988; 62: 2033–2040.

    PubMed  CAS  Google Scholar 

  71. Reuckert RR: Picornaviridae and their Replication. In: Fields BN, Knipe DM (eds): Virology. New York: Raven Press, 1990, pp 507–548.

    Google Scholar 

  72. Rossmann MG: The canyon hypothesis. Virol Immunol 1989; 2: 143–161.

    Article  CAS  Google Scholar 

  73. Rossmann MG, Arnold E, Erickson JW, et al: Structure of a human common cold virus and functional relationship to other picornaviruses. Nature (London) 1985; 317: 145–153.

    Article  CAS  Google Scholar 

  74. Rowlands DJ, Clarke BE, Carroie AR, et al: Chemical basis of antigenic variation in foot and mouth disease virus. Nature (London) 1983; 306: 694–697.

    Article  CAS  Google Scholar 

  75. Rowlands DJ, Sangar DV, Brown F: Buoyant density of picornaviruses in caesium salts. J Gen Virol 1971; 13: 141–152.

    Article  PubMed  CAS  Google Scholar 

  76. Rowlands DJ, Sangar DV, Brown F: Relationship of antigenic structure of foot and mouth disease virus to the process of infection. J Gen Virol 1971; 13: 85–93.

    Article  PubMed  CAS  Google Scholar 

  77. Rweyemamu MM, Hingley PJ: Foot and mouth disease virus strain differentiation; Analysis of the serological data. J Biol Standard 1984; 12: 323–337.

    Article  CAS  Google Scholar 

  78. Salfield J, Pfaff E, Noah M, Schaller H: Antigenic determinants and functional domains in core antigen and e antigen from hepatitis B virus. J Virol 1989; 63: 798.

    Google Scholar 

  79. Schodel F, Will H, Milich DR: Hybrid hepatitis B virus core/pre-s particles expressed in live attenuated Salmonella for oral immunization. In: Chanock RM, Ginsberg HS, Brown F, Lerner RA (eds): Vaccines 91. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1991, pp 319–325.

    Google Scholar 

  80. Siligardi G, Drake AF, Mascagni P, et al: Correlations between the conformations elucidated by CD spectroscopy and the antigenic properties of four peptides of the foot and mouth disease virus (FMDV). Eur J Biochem 1991; 199: 545–551.

    Article  PubMed  CAS  Google Scholar 

  81. Stahl S, Murray K: Immunogenicity of peptide fusions to hepatitis B virus core antigen. Proc Natl Acad Sci USA 1989; 86: 6283–6287.

    Article  PubMed  CAS  Google Scholar 

  82. Stave JW, Card JL, Morgan DO, Vakharia VN: Neutralization sites of type 01 foot and mouth disease virus defined by monoclonal antibodies and neutralization escape virus varients. Virology 1988; 162: 21–29.

    Article  PubMed  CAS  Google Scholar 

  83. Steward MW, Stanley CM, DiMarchi R, et al: High affinity antibody induced by immunization with a synthetic peptide is associated with protection of cattle against foot and mouth disease. Immunology 1991; 72: 99–103.

    PubMed  CAS  Google Scholar 

  84. Strohmaier K, Franze R, Adam KH: Location and characterization of the antigenic portion of FMDV immunizing protein. J Gen Virol 1982; 59: 295.

    Article  PubMed  CAS  Google Scholar 

  85. Surovoi AY, Ivanov VT, Chepurkin AV, et al: Is the Arg-Gly-Asp sequence the binding site of foot and mouth disease virus with the cell receptor? Translated from Bioorg Khim 1988; 14: 965–968.

    CAS  Google Scholar 

  86. Talbot P, Rowlands DJ, Burroughs JN, et al: Evidence for a group protein in foot and mouth disease virus particles. J Gen Virol 1973; 19: 369–380.

    Article  PubMed  CAS  Google Scholar 

  87. Tamm JP: Synthetic peptide vaccine design: Synthesis and properties of a high density multiple antigen peptide system. Proc Natl Acad Sci USA 1988; 85: 5409–5413.

    Article  Google Scholar 

  88. Thomas AAM, Woortmeyer RJ, Puijk W, Barteling SJ: Antigenic sites on foot and mouth disease virus type A10. J Virol 1988; 62: 2782–2789.

    PubMed  CAS  Google Scholar 

  89. Valenzuela P, Coit D, Medina-Selby A, et al: Antigen engineering in yeast: Synthesis and assembly of hybrid hepatitis B surface antigen-herpes simplex I gD particles. Bio/Technology 1985; 3: 323–326.

    Article  CAS  Google Scholar 

  90. Van Bekkum JG: Correlation between serum antibody level and protection against challenge with FMD. Session of the research group of the standing technical committee of the European commission for the control of foot and mouth disease 1969; Brescia, Italy, F.A.O.

    Google Scholar 

  91. Waldmann O, Kobe Z, Pyl G: Die aktive Immunisierung des Rindesgegan Maul-und Klauesseuche mittels Formolinpf-stoff. Zeutbl Bukt Abt 1 Orig 1937; 138: 401.

    Google Scholar 

  92. Wild TF, Burroughs JN, Brown F: Surface structure of foot and mouth disease virus. J Gen Virol 1969; 4: 313–320.

    Article  PubMed  CAS  Google Scholar 

  93. Xie QC, McCahon D, Crowther, JR, et al: Neutralization of foot and mouth disease virus can be mediated through any of at least three separate antigenic sites. J Gen Virol 1987; 68: 1637–1647.

    Article  PubMed  CAS  Google Scholar 

  94. Zibert A, Maass G, Strebel K, et al: Infectious foot and mouth disease virus derived from a cloned full length cDNA. J Virol 1990; 64: 2467–2473.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag New York Inc.

About this chapter

Cite this chapter

Rowlands, D.J. (1993). Progress towards Peptide Vaccines for Foot-and-Mouth Disease. In: Pandey, R., Höglund, S., Prasad, G. (eds) Veterinary Vaccines. Progress in Vaccinology, vol 4. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9226-2_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-9226-2_3

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-9228-6

  • Online ISBN: 978-1-4613-9226-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics