Abstract
The development and differentiation of normal male accessory sex organs depend on endogenous androgen. Much evidence indicates that androgen is also essential for the development of prostate carcinomas, and since Noble (1) first reported grossly recognizable prostate adenocarcinomas after a prolonged administration of testosterone propionate (TP) to Nb rats, there are sufficient data to indicate that exogenous testosterone enhances naturally occurring or chemically induced prostate carcinomas in rodents (2). Invasive and desmoplastic rat prostatic tumors associated with TP have been reported to occur in the dorsolateral lobes. Prolactin has been also shown to play an important role in regulating the growth and function of the prostate gland.
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References
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© 1992 Springer-Verlag New York, Inc.
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Shirai, T., Tamano, S., Iwasaki, S., Ito, N. (1992). Enhancement of Prostate Carcinogenesis in Rats by Testosterone and Prolactin. In: Li, J.J., Nandi, S., Li, S.A. (eds) Hormonal Carcinogenesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9208-8_4
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DOI: https://doi.org/10.1007/978-1-4613-9208-8_4
Publisher Name: Springer, New York, NY
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