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Carcinogenic Risk Assessment of Steroid Hormone Exposure in Relation to Prostate Cancer Risk

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Hormonal Carcinogenesis

Abstract

Cancer of the prostate is presently the most frequently diagnosed cancer and the second most frequent cause of death due to cancer in men in many Western countries, including the US (1). The causes of prostate cancer are poorly understood, in part due to the very old age of most prostate cancer patients, which impedes epidemiological studies (1). Androgenic steroid hormones have been implicated in the etiology of prostate cancer, because many prostate carcinomas are androgen-sensitive, and a role of estrogens has also been suggested (1,2). The purpose of this paper is to attempt to apply the traditional carcinogenic risk-assessment process (3,4) to prostate cancer risk and exposure to androgenic and estrogenic hormonal agents. A major problem in this respect is that significant endogenous as well as exogenous sources of androgenic and estrogenic substances exist, while carcinogenic risk assessment is usually only applied to exogenous agents. Nevertheless, as long as essential information exists, such as dose-response data, it is possible to apply the basic elements of the carcinogenic risk-assessment process, hazard identification, analysis of dose-response data, exposure assessment, and risk characterization and evaluation (3). Risk management, i.e., prevention of prostate cancer, will only be touched upon.

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Authors
  1. Maarten C. Bosland
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Editors and Affiliations

  1. Hormonal Carcinogenesis Laboratory and Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, 99164-6510, Pullman, WA, USA

    Jonathan J. Li Ph.D.  & Sara Antonia Li Ph.D.  & 

  2. Department of Molecular and Cell Biology, Cancer Research Laboratory, University of California, 94720, Berkeley, CA, USA

    Satyabrata Nandi Ph.D.

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© 1992 Springer-Verlag New York, Inc.

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Bosland, M.C. (1992). Carcinogenic Risk Assessment of Steroid Hormone Exposure in Relation to Prostate Cancer Risk. In: Li, J.J., Nandi, S., Li, S.A. (eds) Hormonal Carcinogenesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9208-8_29

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  • DOI: https://doi.org/10.1007/978-1-4613-9208-8_29

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-9210-1

  • Online ISBN: 978-1-4613-9208-8

  • eBook Packages: Springer Book Archive

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