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Functional Aspects of EGF-Like Peptides in Ovarian-Steroid Responsive Organs

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Hormonal Carcinogenesis

Abstract

The sequence of mouse epidermal growth factor (EGF) was reported about two decades ago. During the interim, at least three EGF-like peptide growth factors were discovered, as well as a proto-oncogene (neu or HER-2) that has significant homology to the EGF receptor. Research defining the biological functions of the EGF-like peptides has emphasized identifying their mitogenic or transforming potential. This limited perspective may have obscured determining the full spectrum of their biological functions. The fact that one cell contains receptors for different growth factors suggests that cellular homeostasis is controlled by more than one growth factor receptor pathway. Cell behavior may be regulated by a coordination of tissue-specific stimulatory and inhibitory signals mediated locally by growth factors.

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Authors
  1. Richard P. DiAugustine
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  2. Suzanne M. Snedeker
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  3. Gloria D. Jahnke
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Editor information

Editors and Affiliations

  1. Hormonal Carcinogenesis Laboratory and Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, 99164-6510, Pullman, WA, USA

    Jonathan J. Li Ph.D.  & Sara Antonia Li Ph.D.  & 

  2. Department of Molecular and Cell Biology, Cancer Research Laboratory, University of California, 94720, Berkeley, CA, USA

    Satyabrata Nandi Ph.D.

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© 1992 Springer-Verlag New York, Inc.

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DiAugustine, R.P., Snedeker, S.M., Jahnke, G.D. (1992). Functional Aspects of EGF-Like Peptides in Ovarian-Steroid Responsive Organs. In: Li, J.J., Nandi, S., Li, S.A. (eds) Hormonal Carcinogenesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9208-8_23

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  • DOI: https://doi.org/10.1007/978-1-4613-9208-8_23

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-9210-1

  • Online ISBN: 978-1-4613-9208-8

  • eBook Packages: Springer Book Archive

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