Abstract
Hormones play an important role in a number of human cancers. For example, estrogens influence the incidence of mammary, endometrial, and ovarian cancers in women (1). Estrogens are also carcinogenic in animals. The natural estrogen 17β-estradiol increases the incidences of mammary, pituitary, uterine, cervical, vaginal, and lymphoid tumors, and interstitial-cell tumors of the testes in mice; it also increases the incidences of mammary and pituitary tumors in rats and renal tumors in hamsters (2). Similarly, the synthetic estrogen diethylstilbestrol increases the incidences of mammary tumors, lymphoid tumors, interstitial-cell tumors of the testes, cervical tumors, and vaginal tumors in mice; pituitary, mammary, bladder tumors in rats; and renal tumors in hamsters (2).
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References
Preston-Martin S, Pike MC, Ross RK, Jones PA, and Henderson BE. Increased cell division as cause of human cancer. Cancer Res. 50: 7415–7421, 1990.
International Agency for Research on Cancer, Evaluation of carcinogenic risk of chemicals to humans, sex hormones (11). Vol. 21, IARC, Lyon, 1979.
Barrett FC and Huff J. Cellular and molecular mechanisms of chemically induced carcinogenesis. Renal Failure. In press.
Kaldor JM and Day NE. Interpretation of epidemiological studies on the context of the multistage model of carcinogenesis. In Barrett JC (ed): Mechanisms of environmental carcinogenesis, Vol. II, CRC Press: Boca Raton, Florida, pp. 21–57, 1987.
Forsberg JG. Developmental mechanism of estrogen-induced irreversible changes in the mouse cervicovaginal epithelium. Nat1 Cancer Inst Monogr 51: 41–56, 1979.
McLachlan JA, Newbold RR and Bullock RC. Long-term effects on the female mouse genital tract associated with prenatal exposure to diethylstilbestrol. Cancer Res 40: 3988–3999, 1980.
Newbold RR, Bullock BC and McLachlan JA. Uterine adenocarcinoma in mice following developmental treatment with estrogens: a model for hormonal carcinogenesis. Cancer Res 50: 7677–7681, 1990.
Li JJ, Li SA, Oberley T. Estrogen carcinogenicity: hormonal morphologic and chemical interactions. In Politzer P. & Martin Jr J.F. (eds): Chemical carcinogens. Activation mechanism, structural and electronic factors, and reactivity, New York: Elsevier, 312–321, 1988.
Liehr JG. 2-Fluoroestradiol: separation of estrogenicity from carcinogenicity. Mol Pharmacol 23: 278–281, 1983.
Barrett JC, Wong A and McLachlan JA. Diethylstilbestrol induces neoplastic transformation without measurable gene mutation in two loci. Science 212: 1402–1404, 1981.
McLachlan JA, Wong A, Degen GH and Barrett JC. Morphological and neoplastic transformation of Syrian hamster embryo cells by diethylstilbestrol and its analogs. Cancer Res. 42: 3040–3045, 1982.
Tsutsui T, Maizume H, McLachlan JA, and Barrett JC. Aneuploidy induction and cell transformation by diethylstilbestrol: a possible chromosome mechanism in carcinogenesis. Cancer Res 3814–3821, 1983.
Tsutsui T, Degen GH, Schiffmann D, Wong A, Maizumi H, McLachlan JA, and Barrett JC. Dependence of exogenous metabolic activation for induction of unscheduled DNA synthesis in Syrian hamster embryo cells by diethlstilbestrol and related compounds. Cancer Res 44: 184–189, 1984.
Barrett JC. Relationship between mutagenesis and carcinogenesis. In Barrett JC (ed): Mechanisms of environmental carcinogenesis, Vol. I. CRC Press: Boca Raton, Florida, pp. 129–142, 1987.
Barrett JC, Oshimura M, Tanaka N, and Tsutsui T. Genetic and epigenetic mechanisms of presumed nongenotoxic carcinogens. In Butterworth B. & Slaga TJ (eds): Nongenotoxic mechanisms in carcinogenesis, New York: Cold Spring Harbor Laboratory, pp. 311–324, 1987.
Boyd JC and Barrett JC. Genetic and cellular basis of multistep carcinogenesis. Pharmacol Ther 46: 469–486, 1990.
Callahan R and Campbell G. Mutations in human breast cancer: An overview. J Natl Cancer Inst 81: 1780–1786, 1989.
Dickson RB and Slamon. New insights into breast cancer: The molecular biochemical and cellular biology of breast cancer. Cancer Res 50: 4446–4447, 1990.
Mars WM and Saunders GF. Chromosomal abnormalities in human breast cancer. Cancer Metastasis Rev 9: 35–43, 1990.
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© 1992 Springer-Verlag New York, Inc.
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Barrett, J.C. (1992). Introduction. In: Li, J.J., Nandi, S., Li, S.A. (eds) Hormonal Carcinogenesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9208-8_21
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DOI: https://doi.org/10.1007/978-1-4613-9208-8_21
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