Molecular Mechanisms of Hormonal Carcinogenesis
  • J. Carl Barrett


Hormones play an important role in a number of human cancers. For example, estrogens influence the incidence of mammary, endometrial, and ovarian cancers in women (1). Estrogens are also carcinogenic in animals. The natural estrogen 17β-estradiol increases the incidences of mammary, pituitary, uterine, cervical, vaginal, and lymphoid tumors, and interstitial-cell tumors of the testes in mice; it also increases the incidences of mammary and pituitary tumors in rats and renal tumors in hamsters (2). Similarly, the synthetic estrogen diethylstilbestrol increases the incidences of mammary tumors, lymphoid tumors, interstitial-cell tumors of the testes, cervical tumors, and vaginal tumors in mice; pituitary, mammary, bladder tumors in rats; and renal tumors in hamsters (2).


Renal Tumor Lymphoid Tumor Ethynyl Estradiol Syrian Hamster Embryo Induce Cell Transformation 
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© Springer-Verlag New York, Inc. 1992

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  • J. Carl Barrett

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