Skip to main content

The Influence of Steroid Hormones and Antihormones on the Growth and Differentiation of Normal Human Breast Cells in Culture

  • Conference paper
Hormonal Carcinogenesis

Abstract

Breast cancer still remains the most frequent cancer in women, occurring in 1 out of 9 women, whereas advances in therapeutics have not led to a decrease in mortality. Only a policy of early screening in high-risk populations and of prevention based on a clear pathophysiological understanding could lead to a decrease in the mortality due to this cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Prudhomme JF, Malet C, Gompel A, Lalardrie JP, Ochoa C, Boue A, Mauvais-Jarvis P, Kuttenn F (1984) l7ß-hydroxysteroid dehydrogenase activity in human breast epithelial cell and fibroblast cultures. Endocrinology 114: 1483–1489.

    Google Scholar 

  2. Chomette G, Gompel A, Malet C, Tranbaloc P, Kuttenn F, Mauvais-Jarvis P (1985) Les cellules épithéliales du sein humain normal en culture. Aspects ultrastructuraux et leurs variations sous l’effet d’actions hormonales (estradiol, prolactine). Arch Anat Cytol Path 33: 32–38.

    Google Scholar 

  3. Gompel A, Chomette G, Malet C, Spritzer P, Pavy B, Kuttenn F, Mauvais-Jarvis P (1985) Estradiol-progestin interaction in normal human breast cells in culture. Ultrastructural studies. Breast Diseases 1: 149–156.

    Google Scholar 

  4. Chomette G, Auriol M, Tranbaloc P, Gompel A, Malet C., Kuttenn F (1986) Effect of estradiol and the synthetic progestin promegestone (R5020) on human breast cell cultures. An ultrastructural study. Path Res Pract 181: 273–279.

    Google Scholar 

  5. Malet C, Gompel A, Spritzer P, Kuttenn F, Mauvais-Jarvis P (1986) Effect of estradiol and the synthetic progestin promegestone (R5020) on the proliferation of human epithelial mammary cells in culture. In: Endocrinology of the Breast. Basic and Clinical Aspects. Ann N.Y. Acad Sci 464: 489–492.

    Google Scholar 

  6. Gompel A, Malet C, Spritzer P, Lalardrle JP, Kuttenn F, Mauvais-Jarvis P (1986) Progestin effect on cell proliferation and 17ß-hydroxysteroid dehydrogenase activity in normal human breast cells in culture. J Clin Endocrinol Metab 63: 1174–1180.

    Article  PubMed  CAS  Google Scholar 

  7. Barrat J, Lignieres B de, Marpeau L, Larue L, Fournier S, Nahoul K, Linares G, Giorgi H, Contesso G (1990) Effet in vivo de l’administration locale de progesterone sur l’activité mitotique des galactophores humans J Gynecol Obstet Biol Reprod 19: 269–274.

    CAS  Google Scholar 

  8. Tseng L, Gusberg SB, Gurpide E (1977) Estradiol receptor and 17ßdehydrogenase in normal and abnormal human endometrium. Ann NY Acad Sci 286: 190–198.

    Article  PubMed  CAS  Google Scholar 

  9. Fournier S, Kuttenn F, Cicco N de, Baudot N, Malet C, Mauvais-Jarvis P (1982) Estradiol 17f3-hydroxysteroid dehydrogenase activity in human breast fibroadenomas. J Clin Endocrinol Metab 55: 428–433.

    Article  PubMed  CAS  Google Scholar 

  10. Kuttenn F, Fournier S, Durand JC, Mauvais-Jarvis P (1981) Estradiol and progesterone receptors in human breast fibroadenomas. J Clin Endocrinol Metab 52: 1225–1229.

    Article  PubMed  CAS  Google Scholar 

  11. Malet C, Gompel A, Pritzer P, Bricout N, Yaneva H, Mowszowicz I, Kuttenn F, Mauvais-Jarvis P (1988) Tamoxifen and hydroxytamoxifen isomers vs. estradiol effects on normal human breast cells in culture. Cancer Res 48: 7193–7199.

    PubMed  CAS  Google Scholar 

  12. Malet C, Gompel A, Pritzer P, Bricout N, Yaneva H, Mowszowicz I, Kuttenn F, Mauvais-Jarvis P (1988) Tamoxifen and hydroxytamoxifen isomers vs. estradiol effects on normal human breast cells in culture. Cancer Res 48: 7193–7199.

    PubMed  CAS  Google Scholar 

  13. Dubik D, Dembinski TC, Shiu RP (1987) Stimulation of c-myc oncogene expression associated with estrogen proliferation of human breast cancer cells. Cancer Res 47: 6517–6521.

    PubMed  CAS  Google Scholar 

  14. Dubik D, Shiu RPC (1988) Transcriptional regulation of c-myc oncogene expression by estrogen in hormone responsive human breast cancer cells. J Biol Chem 263: 12705–12708.

    PubMed  CAS  Google Scholar 

  15. Santos GF, Scott GK, Lee WMF, Liu E, Benz C (1988) Estrogen-induced post-transcriptional modulation of c-myc protooncogene expression in human breast cancer cells. J Biol Chem 263: 9565–9568.

    PubMed  CAS  Google Scholar 

  16. Lippman ME, Dickson RB (1989) Mechanisms of growth control in normal and malignant breast epithelium. Rec Prog Horm Res 45: 383–435.

    PubMed  CAS  Google Scholar 

  17. Studzinsky GP, Brelvi ZS, Feldman SC, Watt RA (1986) Participation of cmyc protein in DNA synthesis of human cells. Science 234: 467–470.

    Article  Google Scholar 

  18. Murphy LJ, Murphy LC, Friesen HG (1987) Estrogen induction of N-myc and c-myc protooncogene expression in rat uterus. Endocrinology 120: 1882–1888.

    Article  Google Scholar 

  19. Weisz A, Bresciani F (1988) Estrogen induces expression of c-fos and c-myc protooncogenes in rat uterus. Mol Endocrinol 2: 816–824.

    Article  PubMed  CAS  Google Scholar 

  20. Odom LD, Barrett JM, Pantazis CG, Stoddard LD, Mc Donough PG (1989) Immunocytochemical study of ras and myc protooncogene polypeptide expression in the human menstrual cycle. Am J Obstet Gynecol 161: 1663–1668.

    Article  Google Scholar 

  21. Fink KL, Wieben ED, Woloschak GE, Spelberg TC (1988) Rapid regulation of c-myc protooncogene expression by progesterone in the avian oviduct. Proc Natl Acad Sci 85: 1796–1800.

    Article  PubMed  CAS  Google Scholar 

  22. Gompel A, Leygue E, Gol R, Malet C, Baudot N, Mowszowicz I, Kuttenn F, Mauvais-Jarvis P (1991) Estradiol and antiestrogen interactions with cmyc expresssion in normal human breast epithelial (HBE) cells. 73th Ann Meet Am Endoc Soc, Washington, Abstract 595.

    Google Scholar 

  23. Moolgavkar SH, Day NE, Stevens RC (1980) Two-stage model for carcinogenesis: epidemiology of breast cancer in females. J Natl Cancer Inst 45: 559–569.

    Google Scholar 

  24. Pike M, Henderson B, Krailo M et al (1983) Breast cancer in young women and use of oral contraceptives: possible modifying effect of formulation and age at use. Lancet iî: 926–930.

    Google Scholar 

  25. Bergkvist L, Adami M, Persson I, Hoover R, Schairer C (1989) The risk of breast cancer after estrogen and estrogen-progestin replacement. N Engl J Med 321: 293–297.

    Article  PubMed  CAS  Google Scholar 

  26. Lerner LF, Jordon VC (1990) Development of antiestrogens and their use in breast cancer: Eight Cain Memorial Award Lecture. Cancer Res 50: 41774189.

    Google Scholar 

  27. Bardon S, Vignon F, Derocq D, Rochefort H (1984) The antiproliferative effect of tamoxifen in breast cancer cells: mediation by the estrogen receptor. Moll Cell Endocrinol 35: 89–96.

    Article  CAS  Google Scholar 

  28. Cuzick J, Wang DY, Bulbrook RD (1986) The prevention of breast cancer. Lancet i: 83–86.

    Google Scholar 

  29. Fentiman IS (1989) The endocrine prevention of breast cancer. Br J Cancer 60: 12–14.

    Article  PubMed  CAS  Google Scholar 

  30. Powles TJ, Hardy JR, Ashley SE, Farrington GM, Cosgrove D, Davey JB, Dowsett M, Mc Kinna JA, Nash AG, Sinnett HD, Tyllier CR, Treleaven JG (1989) A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer. Br J Cancer 60: 126–131.

    Article  PubMed  CAS  Google Scholar 

  31. Love RR (1990) Prospects for antiestrogen chemoprevention of breast cancer. J Natl Cancer Inst 82: 18–21.

    Article  PubMed  CAS  Google Scholar 

  32. Eckert RL, Katzenellenbogen BS (1982) Effects of estrogens and antiestrogens on estrogen receptor dynamics and the induction of progesterone receptor in MCF-7 human breast cancer cells. Cancer Res 42: 139–144.

    PubMed  CAS  Google Scholar 

  33. Katzenellenbogen BS, Norman MJ, Eckert RL, Peltz SW, Mangel WF (1984) Bioactivities, estrogen receptor interactions and plasminogen activator-inducing activities of tamoxifen and hydroxytamoxifen isomers in MCF-7 human breast cancer cells. Cancer Res 35: 89–96.

    Google Scholar 

  34. Sherman BM, Chapler FK, Crickard K, Wycoff D (1979) Endocrine consequences of continuous antiestrogen therapy with tamoxifen in premenopausal women. J Clin Invest 64: 398–494.

    Article  PubMed  CAS  Google Scholar 

  35. Fornander T, Cedermark B, Mattsson A et al. (1989) Adjuvant tamoxifen in early breast cancer: Occurrence of new primary cancers. Lancet i, 117119.

    Google Scholar 

  36. Mauvais-Jarvis P, Baudot N, Castaigne D, Banzet P, Kuttenn F (1986) Trans-4-hydroxytamoxifen concentration and metabolism after local percutaneous administration to human breast. Cancer Res 46: 1521–1525.

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag New York, Inc.

About this paper

Cite this paper

Kuttenn, F. et al. (1992). The Influence of Steroid Hormones and Antihormones on the Growth and Differentiation of Normal Human Breast Cells in Culture. In: Li, J.J., Nandi, S., Li, S.A. (eds) Hormonal Carcinogenesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9208-8_20

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-9208-8_20

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-9210-1

  • Online ISBN: 978-1-4613-9208-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics