Abstract
Cell proliferation in tissues and organs is essential to carcinogenesis (1). The classical hormones from ovary, adrenal cortex, and anterior pituitary have been shown to be essential for cell proliferation in the mammary glands, as well as for the carcinogenesis induced in mammary epithelial cells (MEC) by viruses, radiation, and chemical carcinogens. However, this does not explain the origin of the various precancerous and cancerous lesions observed in the mammary glands of rodents and of humans, nor does it explain the mechanisms by which the observed hormonal actions occur.
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References
Preston-Martin S, Pike MG, Ross RK, Jones PA, Henderson BE (1990) Increased cell division as a cause of human cancer. Cancer Res 50: 7415–7421.
Imagawa W, Bandyopadhyay GK, Nandi S (1991) Regulation of mammary epithelial cell growth in mice and rats. Endo Rev 11: 494–523.
Daniel CW, Silberstein GB (1987) Postnatal development of the rodent mammary gland. In: Neville, M. C., Daniel, C. W. (eds) The Mammary Gland: Development, Regulation and Function. Plenum Publishing Corp., New York, pp. 3–36.
Levay-Young BK, Imagawa W, Yang J, Richards JE, Guzman RC, Nandi S (1987) Primary culture system for mammary biology studies. In: Medina D, Kidwell W, Heppner G, Anderson E. (eds) Cellular and Molecular Biology of Mammary Cancer. Plenum Publishing Corp., New York. pp. 181–203.
Yang J, Nandi S (1983) Growth of cultured cells using collagen as substrate. Int Rev Cytol 81: 249–286.
Snedeker SM, Brown CF, DiAugustine RP (1991) Expression and functional properties of transforming growth factor a and epidermal growth factor during mouse mammary gland ductal morphogenesis. Proc Nat Acad Sci USA 88: 276–280.
Medina D (1974) Mammary tumorigenesis in carcinogen-treated mice. II. Dependence on hormone stimulation for tumorigenesis. J Nat Cancer Inst 53: 223–226.
Medina D, Warner MR (1978) Mammary tumorigenesis in chemical carcinogen-treated mice. IV. Induction of mammary ductal hyperplasia. J Nat Cancer Inst 47: 331–337.
Guzman RC, Osborn RC, Bartley JC, Imagawa W, Asch BB, Nandi S (1987) In vitro transformation of mouse mammary epithelial cells grown serum-free inside collagen gels. Cancer Res 47:275–280.
Miyamoto S, Guzman RC, Osborn RC, Nandi S. (1988) Neoplastic transformation of mouse mammary epithelial cells by in vitro exposure to N-methyl-N-nitrosourea. Proc Nat Acad Sci USA 85: 447–481.
Miyamoto S, Sukumar S, Guzman RC, Osborn RC, Nandi S (1990) Transforming C-K-ras mutation is an early event in mouse mammary carcinogenesis induced in vitro by N-methyl-N-nitrosourea. Mol Cell Biol 10: 1593–1599.
Bresciani F (1968) Topography of DNA synthesis in the mammary gland of the C3H mouse and its control by ovarian hormones: an autoradiographic study. Cell and Tissue Kinet 1: 51–63.
Du Bois M, Elias JJ (1984) Subpopulations of cells in immature mouse mammary gland as detected by proliferative responses to hormones in organ culture. Dev Biol 106: 70–75.
Liscia DS, Merlo G, Ciardiello F, Kim N, Smith GH, Callahan R, Solomon DS (1990) Transforming growth factor-a messenger RNA localization in the developing adult rat and human mammary gland by in situ hybridization. Dev Biol 140: 123–131.
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© 1992 Springer-Verlag New York, Inc.
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Nandi, S., Guzman, R.C., Miyamoto, S. (1992). Hormones, Cell Proliferation, and Mammary Carcinogenesis. In: Li, J.J., Nandi, S., Li, S.A. (eds) Hormonal Carcinogenesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9208-8_10
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DOI: https://doi.org/10.1007/978-1-4613-9208-8_10
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