Skip to main content
SpringerLink
Log in

The Intraovarian Insulinlike Growth Factor System: Basic and Clinical Implications

  • Chapter
Technology and Infertility

Abstract

The rationale for thinking of growth factors, insulinlike growth factors among others, in the context of ovarian physiology has to do with the recognition that the process of follicular development is exponential rather than linear. When the follicle finally takes off somewhere in the midfollicular phase it really grows in an exponential fashion. It increases its cell endowment in a manner not paralleled in its previous course of development, while producing a variety of steroid hormones, of which estrogens are just one example. This is a dramatic series of events in which somatic ovarian cells undergo marked differentiation and proliferation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliography

  1. Hammond JM. Peptide regulators in the ovarian follicle. Aust J Biol Sci 1981; 34: 491–504.

    PubMed  CAS  Google Scholar 

  2. Hammond JM, Baranao JLS, Skaleris D, Knight AB, Romanus J A, Rechler MM. Production of insulinlike growth factors by ovarian granulosa cells. Endocrinology 1985; 117: 2553–2555.

    Article  PubMed  CAS  Google Scholar 

  3. Hsu C-J, Hammond JM. Gonadotropins and estradiol stimulate immunoreactive insulinlike growth factor I production by porcine granulosa cells in vitro. Endocrinology 1987; 120: 198–207.

    Article  PubMed  CAS  Google Scholar 

  4. Davoren JB, Hsueh AJW. Growth hormone increases ovarian levels of immunoreactive somatomedin-C/insulinlike growth factor I in vivo. Endocrinology 1986; 118: 888–890.

    Article  PubMed  CAS  Google Scholar 

  5. Hernandez ER, Roberts CT, LeRoith D, Adashi EY. Rat ovarian insulinlike growth factor (IGF I) gene expression is granulosa cell-selective: 5’-untranslated mRNA variant representation and hormonal regulation. Endocrinology 1989; 125: 572–574.

    Article  PubMed  CAS  Google Scholar 

  6. Murphy LJ, Bell GI, Friesen HB. Tissue distribution of insulinlike growth factor I and II messenger ribonucleic acid in the adult rat. Endocrinology 1987; 120: 1279–1282.

    Article  PubMed  CAS  Google Scholar 

  7. Voutilainene R, Miller WL. Coordinate tropic hormone regulation of mRNAs for insulinlike growth factor II and the cholesterol side-chain- cleavage enzyme, P450ssc, in human steroidogenic tissues. Proc Natl Acad Sci USA 1987; 84: 1590–1594.

    Article  Google Scholar 

  8. Veldhuis JD, Furlanetto RW, Juchter D, Garmey J, Veldhuis P. Trophic actions of human somatomedin-C/insulinlike growth factor I on ovarian cells: In vitro studies with swine granulosa cells. Endocrinology 1985; 116: 1235–1242.

    CAS  Google Scholar 

  9. Davoren JB, Kasson BG, Li CH, Hsueh AJW. Specific insulinlike growth factor (IGF) I- and II-binding sites on rat granulosa cells: Relation to IGF action. Endocrinology 1986; 119: 2155–2162.

    CAS  Google Scholar 

  10. Adashi EY, Resnick CE, Hernandez ER, Svoboda ME, Van Wyk JJ. Characterization and regulation of a specific cell membrane receptor for Somatomedin C/Insulinlike Growth Factor I in cultured rat granulosa cells. Endocrinology 122: 194–201.

    Google Scholar 

  11. Adashi EY, Rensnick CE, Svoboda ME, Van Wyk JJ. Follicle-stimulating hormone enhances somatomedin-C binding to cultured rat granulosa cells: Evidence for cAMP-dependence. J Biol Chem 1986; 261: 3923–3926.

    PubMed  CAS  Google Scholar 

  12. Adashi EY, Rensnick CE, Rosenfeld RG. Insulin-like growth factor-I (IGF-I) and IGF-I hormonal action in cultured rat granulosa cells: Mediation via type I but not type II IGF receptors. Endocrinology 1990; 126: 216–222.

    PubMed  CAS  Google Scholar 

  13. Adashi EY, Resnick CE, D’Ercole AG, Svoboda ME, Van Wyk JJ. Insulinlike growth factors as intraovarian regulators of granulosa cell growth and function. Endocr Rev 1985; 6: 400–420.

    Article  PubMed  CAS  Google Scholar 

  14. Adashi EY, Resnick CE, Svoboda ME, Van Wyk JJ, Hascall VC, Yanagishita M. Independent and synergistic actions of somatomedin-C in the stimulation of proteoglycan biosynthesis by cultured rat granulosa cells. Endocrinology 1986; 118: 456–459.

    Article  PubMed  CAS  Google Scholar 

  15. Binoux M, Hossenlopp P, Hardouin S, Seurin D, Lassarre C, Gourmelen M. Somatomedin (insulin-like growth factors)-binding proteins: Molecular forms and regulation. Hormone Res 1986; 24: 141–151.

    CAS  Google Scholar 

  16. Baxter RC. The insulinlike growth factors and their binding proteins. Comp Biochem Physiol 1988; 91B: 229–235.

    CAS  Google Scholar 

  17. Mottola C, MacDonald RG, Brackett JL, Mole JE, Anderson JK, Czeck MP. Purification and amino-terminal sequence, of an insulinlike growth factor-binding protein secreted by rat liver BRL-3A cells. J Biol Chem 1986; 261: 11180–11188.

    PubMed  CAS  Google Scholar 

  18. Brown AL, Chiariotti L, Orlowski CC, Mehlman T, Burgess WH, Ackerman EJ, Bruni CB, Rechler MM. Nucleotide sequence and expression of a cDNclone encoding a fetal rat binding protein for insulinlike growth factors. J Biol Chem 1989; 264: 5148–5154.

    PubMed  CAS  Google Scholar 

  19. Margot JB, Binkert C, Mary J-L, Landwehr J, Heinrich G, Schwander J. A low molecular weight insulinlike growth factor binding protein from rat: cDNA cloning and tissue distribution of its messenger RNA. Mol Endocrinol 1989; 3: 1053–1066.

    Article  PubMed  CAS  Google Scholar 

  20. Ruoslahti E, Pierschbacher MD. New perspectives in cell adhesion: RGD and integrins. Science 1987; 238: 491–497.

    Article  PubMed  CAS  Google Scholar 

  21. De Vroede MA, Tseng LY-H, Katsoyannis PG, Nissley SP, Rechler MM. Modulation of insulinlike growth factor I binding to human fibroblast monolayer cultures by insulinlike growth factor carrier proteins released to the incubation media. J Clin Invest 1986; 77: 602–613.

    Article  PubMed  Google Scholar 

  22. Elgin RG, Busby WJ Jr., Clemmons DR. An insulinlike growth factor (IGF) binding protein enhances the biologic response to IGF-I. Proc Natl Acad Sci USA 1987; 84: 3254–3258.

    Article  PubMed  CAS  Google Scholar 

  23. Drop SLS, Valiquette G, Guyda HJ, Corvol MT, Posner BI. Partial purification and characterization of a binding protein for insulinlike activity (ILAs) in human amniotic fluid: A possible inhibitor of insulinlike activity. Acta Endocr (Copenh) 1979; 90: 505–518.

    CAS  Google Scholar 

  24. Ritvos O, Tanta P, Jalkanen J, Suikkari AM, Voutilainen R, Bohn H, Rutanen EM. Insulinlike growth factor (IGF) binding protein from human decidua inhibits the binding and biological action of IGF-I in cultured chorio-carcinoma cells. Endocrinology 1988; 122: 2150–2157.

    Article  PubMed  CAS  Google Scholar 

  25. Seppala M, Wahlstrom T, Koskimies AI, et al. Human preovulatory follicular fluid, luteinized cells of hyperstimulated preovulatory follicles, and corpus luteum contain placental protein 12. J Clin Endocrinol Metab 1984; 58: 505–510.

    Article  PubMed  CAS  Google Scholar 

  26. Seppala M, Than G. Insulinlike growth factor binding protein PP12 in ovarian cyst fluid. Arch Gynecol Obstet 1987; 241: 33–35.

    Article  PubMed  CAS  Google Scholar 

  27. Suikkari AM, Jalkanen J, Koistinen R, Butzow R, Ritvos O, Ranta T, Seppala M. Human granulosa cells synthesize low molecular weight insulinlike growth factor binding protein. Endocrinology 1989; 124: 1088–1090.

    Article  PubMed  CAS  Google Scholar 

  28. Davoren JB, Hsueh AJW. Growth hormone increases ovarian levels of immunoreactive somatomedin C/insulinlike growth factor I in vivo. Endocrinology 1986; 118: 888–890.

    Article  PubMed  CAS  Google Scholar 

  29. Ui M, Shimonaka M, Shimasaki S, Ling N. An insulinlike growth factor-binding protein in ovarian follicular fluid blocks follicle-stimulating steroid production by ovarian granulosa cells. Endocrinology 1989; 125: 912–916.

    Article  PubMed  CAS  Google Scholar 

  30. Adashi EY, Resnick CE, Hernandez ER, Hurwitz A, Rosenfeld RG. Follicle-stimulating hormone inhibits the constitutive release of insulinlike growth factor binding proteins by cultured rat ovarian granulosa cells. Endocrinology 1990; 126: 1305–1307.

    Article  PubMed  CAS  Google Scholar 

  31. Homburg R, Eshel A, Abdalla HI, Jacobs HS. Growth hormone facilitates ovulation induction by gonadotropins. Clin Endocrinol 1988; 29: 113–117.

    Article  CAS  Google Scholar 

Download references

Authors
  1. Eli Y. Adashi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Harvard Medical School, USA

    Machelle M. Seibel M.D.

  2. Faulkner Centre for Reproductive Medicine, Faulkner Hospital, Boston, MA, 02130, USA

    Machelle M. Seibel M.D.  & Judith Bernstein R.N., M.S.  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag New York Inc.

About this chapter

Cite this chapter

Adashi, E.Y. (1993). The Intraovarian Insulinlike Growth Factor System: Basic and Clinical Implications. In: Seibel, M.M., Bernstein, J. (eds) Technology and Infertility. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9205-7_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-9205-7_15

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-9207-1

  • Online ISBN: 978-1-4613-9205-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation