The Natural Cycle for In Vitro Fertilization

  • Machelle M. Seibel


Although the first in vitro fertilization (IVF) success occurred using natural cycles, the majority of IVF centers around the world favor the use of ovulation-inducing medications prior to oocyte retrieval. The concept of using ovulation-inducing medications for IVF evolved for a number of reasons. When the procedure was being developed, a laparotomy was required to retrieve oocytes. Laparoscopy replaced laparotomy as the method of choice for oocyte retrieval unless extensive adhesions made laparoscopy unsuitable. In addition, embryo culture techniques were less good, ultrasound had poorer resolution, and the detection of ovulation was less precise. For all of these reasons, the initial results using the natural cycle were poor and a tendency to use medication evolved. An increasingly large number of ovulation-inducing drugs are now being used individually or in combination for IVF. The primary goal of all medicated cycles is to increase the number of available oocytes for fertilization and transfer.


Human Chorionic Gonadotropin Estradiol Level GnRH Agonist Oocyte Retrieval Natural Cycle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Garcia J. Return to the natural cycle for in vitro fertilization (alleluia! Alleluia!). J In Vitro Fert Embryo Transf 1989; 6: 67.PubMedCrossRefGoogle Scholar
  2. 2.
    Paulson RJ, Sauer MV, Lobo RA. In vitro fertilization in unstimulated cycles: A new application. Fertil Steril 1989; 51: 1059.PubMedGoogle Scholar
  3. 3.
    Foulot H, Ranoux C, Dubuisson JB, Rambaud D, Aubriot FX, Porirot C. In vitro fertilization without ovarian stimulation: A simplified protocol applied in 80 cycles. Fertil Steril 1989; 52: 617.PubMedGoogle Scholar
  4. 4.
    Scott RT, Toner JP, Muasher SJ, Oehniger S, Robinson S, Rosenwaks Z. Follicle-stimulating hormone levels on cycle day 3 are predictive of in vitro fertilization outcome. Fertil Steril 1989; 51: 651.PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1993

Authors and Affiliations

  • Machelle M. Seibel

There are no affiliations available

Personalised recommendations