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Cor Pulmonale

  • Elliot Chesler

Abstract

Cor pulmonale is the term used to describe hypertrophy and dilatation of the right ventricle as the result of lung disease. Although the causes of cor pulmonale are diverse, they have as their common effect, the production of alveolar hypoxia producing pulmonary arterial vasoconstriction and/or an anatomical reduction of the pulmonary vascular bed. When these changes are severe and bilateral, pulmonary arterial hypertension develops and this is responsible for the pathogenesis of cor pulmonale. Passive pulmonary arterial hypertension secondary to left atrial hypertension (e.g., left ventricular failure or mitral valve disease) and hyperkinetic pulmonary hypertension secondary to left-to-right shunts (ASD, VSD etc.) are specifically excluded from this definition. Malfunction of the lungs may not only be because of parenchymal disease but also a result of failure of the bellows action of the chest or ventilatory drive by the central nervous system.

Keywords

Pulmonary Hypertension Mitral Stenosis Main Pulmonary Artery Mitral Valve Disease Congestive Cardiac Failure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Burwell CS, Robin ED, Whaley RD, Bickelman AG: Extreme obesity associated with alveolar hypoventilation—A Pickwickian syndrome. Am J Med 21: 89, 1965.Google Scholar
  2. Friedberg CK: Pulmonary function tests and the clinical applications. Prog Cardiovasc Dis 1: 251, 1958.CrossRefGoogle Scholar
  3. Moser KM (ed): “Pulmonary Vascular Diseases.” Marcel Dekker, New York, 1979.Google Scholar
  4. Oakley CM, Goodwin JF: Current clinical aspects of cor pulmonale. Am J Cardiol 20: 842, 1967.PubMedCrossRefGoogle Scholar
  5. Oakley CM, Goodwin JF: The current status of pulmonary embolism and pulmonary vascular disease in relation to pulmonary hypertension. Prog Cardiovasc Dis 9: 495, 1966.CrossRefGoogle Scholar
  6. West JB: Diffusion and impaired gas exchange. Br J Dis Chest 59: 185, 1965.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1993

Authors and Affiliations

  • Elliot Chesler
    • 1
  1. 1.Veterans Administration Medical CenterUniversity of MinnesotaMinneapolisUSA

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