Skip to main content

Neurobiological Factors in Self-injurious Behavior

  • Chapter
Self-injurious Behavior

Part of the book series: Disorders of Human Learning, Behavior, and Communication ((HUMAN LEARNING))

Abstract

Self-injurious behavior is a relatively infrequent problem in the general population but a serious one, particularly when it occurs in severely retarded and psychiatrically disturbed individuals. The term self-injurious behavior or SIB is used when referring to the mentally retarded population, and the term deliberate self-harm syndrome or DSH (Pattison & Kahan, 1983) has been proposed to describe self-aggression in emotionally disturbed individuals. SIB is one of the least understood and most difficult behavioral problems to treat in the developmentally disabled population. It is characterized by multiple episodes of physically self-damaging acts of low lethality, although the cumulative effect of this behavior may be life-threatening.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abe, K., Oda, N., & Amatomi, M. (1984). Natural history and predictive significance of head banging, headrolling, and breath holding spells. Developmental Medicine and Child Neurology, 26, 644–648.

    Article  PubMed  Google Scholar 

  • American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders (3rd ed. rev.). Washington, DC: Author.

    Google Scholar 

  • Anderson, J. R., & Chamove, A. S. (1980). Self-aggression and social aggression in laboratory reared macaques. Journal of Abnormal Psychology, 89, 539–550.

    Article  PubMed  Google Scholar 

  • Anderson, L., Dancis, J., & Alpert, M. (1978). Behavioral contingencies and self-mutilation in Lesch—Nyhan disease. Journal of Consulting and Clinical Psychology, 3, 529–536.

    Article  Google Scholar 

  • Anderson, L., Dancis, J., Alpert, M., & Herman, L. (1977). Punishment learning and self-mutilation in Lesch—Nyhan disease. Nature, 265, 461–463.

    Article  PubMed  Google Scholar 

  • Anderson, L. T., Hermann, L., Alpert, M., & Dancis, T. (1975). Elimination of self-mutilation in Lesch—Nyhan disease. Pediatric Research, 9, 257.

    Google Scholar 

  • Bachman, J. A. (1972). Self-injurious behavior: A behavioral analysis. Journal of Abnormal Psychology, 80, 211–224.

    Article  PubMed  Google Scholar 

  • Baroff, G. S., & Tate, B. S. (1968). The use of aversive stimulation in the treatment of chronic self-injurious behavior. Journal of American Academy of Child Psychiatry, 7, 454–460.

    Article  Google Scholar 

  • Bartak, L., & Rutter, M. (1976). Differences between mentally retarded and normally intelligent autistic children. Journal of Autism and Childhood Schizophrenia, 6, 109–120.

    Article  PubMed  Google Scholar 

  • Bauman M., & kemper, T. L. (1985). Histoanatomical observations of the brain in early infantile autism. Neurology, 35, 866–874.

    PubMed  Google Scholar 

  • Baumeister, A. A., & Frye, G. D. (1985). The biochemical basis of the behavioral disorder in the Lesch—Nyhan syndrome. Neuroscience and Biobehavioral Reviews, 9, 169–178.

    Article  PubMed  Google Scholar 

  • Baumeister, A. A., Frye, G. D., & Moore, L. L. (1987). An investigation of the role played by the superior colliculus and ventromedial thalamus in self-injurious behavior produced by intranigral microinjection of muscimol. Pharmacology, Biochemistry, and Behavior, 26, 187–189.

    Article  PubMed  Google Scholar 

  • Baumeister, A., & Rollings, J. P. (1976). Self-injurious behavior. International Review of Research in Mental Retardation, 8, 1–34.

    Article  Google Scholar 

  • Belluzzi, J. D., & Stein, L. (1977). Enkephalin may mediate euphoria and drive-reduction reward. Nature, 266, 556–558.

    Article  PubMed  Google Scholar 

  • Berg, J. M., McCreary, B. D., Ridler, M. A. C., & Smith, G. F. (1970). The de Lange syndrome. Oxford: Pergamon Press.

    Google Scholar 

  • Bernstein, G. A., Hughes, J. R., Mitchell, J. E., & Thompson, T. (1987). Effects of narcotic antagnoists on self-injurious behavior: A single case study. Journal of the American Academy of Child and Adolescent Psychiatry, 26, 886–889.

    PubMed  Google Scholar 

  • Bhattacharya, S. K., Jaiswal, A. K., Mukhopadhyay, M., & Datla, K. P. (1988). Clonidine-induced automutilation in mice as a laboratory model for clinical self-injurious. Journal of Psychiatric Research, 22, 43–50.

    Article  PubMed  Google Scholar 

  • Breese, G. R., Baumeister, A. A., McCown, T. J., Emerick, S. G., Frye, G. D., Crotty, K., & Mueller, R. A. (1984). Behavioral differences between neonatal and adult 6-hydroxy-dopamine-treated rats to dopamine agonists: Relevance to neurological symptoms in clinical syndromes with reduced brain dopamine. Journal of Pharmacology and Experimental Therapeutics, 231, 343–354.

    PubMed  Google Scholar 

  • Buchsbaum, M. S., Davis, G. C., & Bunny, W. G. (1977). Naloxone alters pain perception and somatosensory evoked potentials in normal subjects. Nature, 267, 620–622.

    Article  Google Scholar 

  • Busbaur, A. I (1974). Effects of central lesion on disorders produced by dorsal rhizotomy in rats. Experimental Neurology, 42, 490–501.

    Article  Google Scholar 

  • Campbell, M. (Personal communication). AACP meeting, 1990.

    Google Scholar 

  • Campbell, M., Anderson, L. T., Small. A. M., Perry, R., Green, W. H., and Caplan, R. (1982). The effects of haloperidol on learning and behavior in autistic children. Journal of Autism and Developmental Disorders, 12, 167–75.

    Google Scholar 

  • Campbell, M., Overall, J. E., Small, A. M., Sokol, M. S., Spencer, E. K., & Adams, P. (1989). Naltrexone in autistic children: An acute open dose range tolerance trial. Journal of the American Academy of Child and Adolescent Psychiatry, 28, 200–206.

    Article  PubMed  Google Scholar 

  • Carr, E. G. (1977). The motivation of self-injurious behavior: A review of some hypotheses. Psychological Bulletin, 84, 800–816.

    Article  PubMed  Google Scholar 

  • Cataldo, M. F., & Harris, J. C. (1982). The biological basis for self-injury in the mentally retarded. Analysis and Intervention in Developmental Disabilities, 2, 21–39.

    Article  Google Scholar 

  • Charmove, A. S., & Harlow, H. F. (1970). Exaggeration of self-aggression following alcohol ingestion in rhesus monkeys. Journal of Abnormal Psychology, 75, 207–209.

    Article  Google Scholar 

  • Clark, D. L., Kreutzberg, J. R., & Chee, F. K. W. (1977). Vestibular stimulation influence on motor development in infants. Science, 196, 1228–1229.

    Article  PubMed  Google Scholar 

  • Cools, A. R., Wiegant, U. M., & Gispen, W. H. (1978). Distinct dopaminergic systems in ACTH induced grooming. European Journal of Pharmacology, 50, 265–68.

    Article  PubMed  Google Scholar 

  • Courchesne, E., Yeung-Courchesne, R., Press, G. A., Hesselink, J. R., & Jernigan, T. L. (1988). Hypoplasia of cerebellar vermal lobules VI and VII in infantile autism. New England Journal of Medicine. 318, 1349–1354.

    Article  PubMed  Google Scholar 

  • Davidson, P. W., Kleene, B. M., Carroll, M., & Rockowitz, R. J. (1983). Effects of naloxone on self injurious behavior: A case study. Applied Research in Mental Retardation, 4, 1–4.

    Article  PubMed  Google Scholar 

  • Davis, K. (1940). Extreme isolation of a child. American Journal of Sociology, 45, 554–565.

    Article  Google Scholar 

  • Davis, K. (1946). Final note on a case of extreme isolation. American Journal of Sociology, 52, 432–437.

    Article  Google Scholar 

  • Dehen, H., Amsallem, B., Colas-Linhart, N., & Cambier, J. (1986). Cerebrospinal fluid beta endorphin in congenital insensitivity to pain. Review of Neurology (Paris), 142, 541–544.

    Google Scholar 

  • Dehen, H., Willer, J. C., Boureau, F., & Cambier, J. (1977). Congenital insensitivity to pain, and endogenous morphine-like substances. Lancet, 2, 293–294.

    Article  PubMed  Google Scholar 

  • De Lange, C. (1933). Sur un type nouveau de degeneration (Typus Amstelodamensis). Archives de Medicine des Enfants, 36, 713–719.

    Google Scholar 

  • De Lissovoy, V. (1962). Head-baning in early childhood. Child Development, 33, 43–56.

    Article  Google Scholar 

  • De Lissovoy, V. (1963). Head-banging in early childhood. A suggested cause. Journal of Genetic Psychology, 102, 109–114.

    Google Scholar 

  • Delius, J. D., Craig, B., & Chaudoir, C. (1976). Adrenocorticotropic hormone. Glucose displacement activities in pigeon. Zeitschrift fur Tierpsychologie, 40, 183–193.

    Article  PubMed  Google Scholar 

  • Fellow, P., & Tennstedt, A. (1986). Cornelia de Lange syndrome with analgesia. Psychiatry Neurology Medicine and Psychology, 38, 33–38.

    Google Scholar 

  • Frankel, F., & Simmons, J. Q. (1976). Self-injurious behavior in schizophrenic and retarded children. American Journal of Mental Deficiency, 80, 512–522.

    PubMed  Google Scholar 

  • Freedman, D. A., & Brown, S. L. (1968). On the role of coenesthetic stimulation in the development of psychic structure. Psychoanalytic Quarterly, 37, 418–438.

    PubMed  Google Scholar 

  • Fryns, J. P., Jacobs, J., Kleczkowska, A., & Van Den Berghe, H. (1984). The psychological profile of fragile X syndrome. Clinical Genetics, 25, 131–34.

    Article  PubMed  Google Scholar 

  • Geller, E., Ritvo, E. R., Freeman, B. J., & Yuwiler, A. (1982). Preliminary observations on the effect of fenfluramine on blood serotonin and symptoms in three autistic boys. New England Journal of Medicine, 307, 165–169.

    Article  PubMed  Google Scholar 

  • Gilbert, S., Spellacy, E., & Watts, R. W. E. (1979). Problems in the behavioral treatment of self-injury in the Lesch-Nyhan syndrome. Developmental Medicine and Child Neurology, 21, 795–800.

    Article  PubMed  Google Scholar 

  • Gispen, W. H., Wiegant, V. M., Greven, H. M., & de Wied, D. (1976). The induction of excessive grooming in the rat by intraventricular application of peptides derived from ACTH: Structure-activity studies. Life Sciences, 17, 645–652.

    Google Scholar 

  • Gjedde, A., Wong, D. F., Harris, J., Dannals, R. F., & Ravert, H. T. (1986). Quantification of Dl and D2 dopamine receptors in Lesch-Nyhan syndrome as measured by positron tomography. Society for Neuroscience Abstracts, 12, 486.

    Google Scholar 

  • Gogas, K. R., & Hough, L. B. (1988). H2 receptor mediated stress induced analgesia is dependent on neither pituitary nor adrenal activation. Pharmacology, Biochemistry, and Behavior, 30, 791–794.

    Article  PubMed  Google Scholar 

  • Goldstein, M., Anderson, L. T., Reuben, R., & Dancis, J. (1985). Self-mutilation in Lesch-Nyhan disease is caused by dopaminergic denervation. Lancet, 1, 338–339.

    Article  PubMed  Google Scholar 

  • Goosen, C., & Ribbens, L. G. (1980). Autoaggression and tactile communication in pairs of adult stump tailed macaques. Behavior, 73, 155–174.

    Article  Google Scholar 

  • Green, A. H. (1967). Self mutilation in schizophrenic children. Archives of General Psychiatry, 17, 234–244.

    PubMed  Google Scholar 

  • Greenberg, A., & Coleman, M. (1973). Depressed whole blood serotonin levels associated with behavioral abnomalities in the de Lange syndrome. Pediatrics, 51, 720–724.

    Google Scholar 

  • Griffin, J. C., Ricketts, R. W., Williams, D. E., Locke, B. J., Altmeyer, B. K., & Stark, M. T. (1987). A community survey of self-injurious behavior among developmentally disabled children and adolescents. Hospital and Community Psychiatry, 38, 959–963.

    PubMed  Google Scholar 

  • Hagerman, R. J., Jackson, A. W., Levitas, A., Rimland, B., & Braden, M. (1986). An analysis of autism in fifty males with fragile X syndrome. American Journal of Medical Genetics, 23, 359–374.

    Article  PubMed  Google Scholar 

  • Hamilton, M. (1985). Fish’s clinical psychopathology: Signs and symptoms in psychiatry. Bristol: John Wright and Sons.

    Google Scholar 

  • Harris, J. C. (1987). Behavioral phenotypes in mental retardation syndromes. In R. Barrett and J. Matson (Eds.), Advances in developmental disorders (Vol. 1 ), pp. 77–106. New York: JAI Press.

    Google Scholar 

  • Harris, J. C., Wong, D. F., Wagner, H. N., Rett, A., & Naidu, S. (1986). Positron emission tomographic study of D2 dopamine receptor binding and CSF biogenic animal metabolites in Rett syndrome. Americal Journal of Medical Genetics, 24, 201–210.

    Article  Google Scholar 

  • Hawley, P. P., Jackson, L. G., & Kurnit, D. M. (1985). Sixty four patients with Brackman de Lange syndrome: A survey. American Journal of Medical Genetics, 20, 453–459.

    Article  PubMed  Google Scholar 

  • Hennessey, J. W., & Levine, S. (1979). Stress, arousal, and the pituitary adrenal system: A psychoendocrine hypothesis. In J. M. Strague and A. N. Epstein (Eds.), Progress in psychobiology and physiological psychology (Vol. 8 ). New York: Academic Press.

    Google Scholar 

  • Hosobuchi, Y. (1981). Periaqueductal gray simulation in humans produces analgesia accompanied by elevation of beta-endorphin and ACTH in ventricular CSF. Modern Problems in Pharmacopsychiatry, 17, 109–122.

    Google Scholar 

  • Hutt, C., & Hutt, S. J. (1968). Stereotypes and their relation to arousal: A study of autistic children. In S. J. Hutt and C. Hutt (Eds.), Behavior studies in psychiatry. London: Pergamon.

    Google Scholar 

  • Iriki, A., Shuicki, N., & Nakamura, Y. (1988). Feeding behavior in mammals: Corticobulbar projection is reorganized during conversion from sucking to chewing. Developmental Brain Research, 44, 189–196.

    Article  PubMed  Google Scholar 

  • Iwata, B. A., Pace, G. M., Willis, K. D., Gamache, T. B., & Hyman, S. L. (1986). Operant studies of self-injurious hand biting in the Rett syndrome. American Journal of Medical Genetics, 24, 157–166.

    Article  Google Scholar 

  • Jenson, W.R., Rovner, L., Cameron, S., Petersen, B. P., & Kesler, J. (1985). Reduction of self-injurious behavior in an autistic girl using a multifaceted treatment program. Journal of Behavior Therapy and Experimental Psychiatry, 16, 77–80.

    Article  PubMed  Google Scholar 

  • Johnson, W., & Baumeister, A. (1978). A self-injurious behavior: A review and analysis of methodological details of published studies. Behavior Modification, 2, 465–484.

    Article  Google Scholar 

  • Jolles, J., Rompa-Barendregt, J., & Gispen, W. H. (1979). ACTH-induced excessive grooming in the rat: The influence of environmental and motivational factors. Hormones and Behavior, 12, 60–72.

    Article  PubMed  Google Scholar 

  • Jones, I. H., & Barraclough, B. M. (1978). Auto-mutilation in animals and its relevance to self-injury in man. Acta Psychiatrica Scandinavia, 58, 40–47.

    Article  Google Scholar 

  • Jones, I. H. (1982). Self-injury: Toward a biological basis. Perspectives in Biology and Medicine, 26, 137–150.

    PubMed  Google Scholar 

  • Kahkonen, M., Leisti, J., Thoden, C. J., & Autio, S. (1986). Frequency of rare. Fragile sites among mentally subnormal school children. Clin Genetics, 30: 234–238.

    Article  Google Scholar 

  • Katsuragi, T. I., Ushijima & Furukawa, T. (1984). The clonidine-induced self-injurious behavior of mice involves purinergic mechanisms. Pharmacology Biochemistry and Behavior, 20, 943–946.

    Google Scholar 

  • Kelly, D. D. (1982). The role of endorphins in stress-induced agalgesia. Annals of the New York Academy of Science, 398, 260–271.

    Article  Google Scholar 

  • Kluver, H., & Bucy, A. S. (1939). Preliminary analysis of functions of the temporal lobe in monkeys. Archives of Neurology and Psychiatry, 42, 978–1000.

    Google Scholar 

  • Kopin, I. J. (1981). Neurotransmitters and the Lesch-Nyhan syndrome. The New England Journal of Medicine, 305, 1148–1150.

    Article  PubMed  Google Scholar 

  • Kravitz, H., Vin Rosenthal, Y., Teplitz, Z., Murphy, I., & Lesser, R. (1960). A study of headbanging in infants and children. Diseases of the Nervous System, 21, 203–208.

    PubMed  Google Scholar 

  • Kuhar, M. J., Pert, C. B., & Snyder, S. H. (1973). Regional distribution of opiate receptor binding in the monkey and human brain. Nature, 245, 447–450.

    Article  PubMed  Google Scholar 

  • Largo, R. H., & Schinzel, A. (1985). Developmental and behavioral disturbances in 13 boys with fragile X syndrome. European Journal of Pediatrics, 143, 269–75.

    Article  PubMed  Google Scholar 

  • Lal, H. (1975). Narcotic dependence, narcotic action, and dopamine receptors. Life Sciences, 17, 483–496.

    Article  PubMed  Google Scholar 

  • Lesch, M., & Nyhan, W. L. (1964). A familial disorder of uric acid metabolism and central nervous system function. American Journal of Medicine, 36, 561–570.

    Article  PubMed  Google Scholar 

  • Lewis, J. W., Tordoff, M. G., Sherman, J. E., & Liebeskind, J. C. (1982). Adrenal medullary enkephalin-like peptides may mediate opioid stress analgesia. Science, 217, 557–559.

    Article  PubMed  Google Scholar 

  • Lloyd, H. G. E., & Stone, T. W. (1981). Chronic methylxanthine treatment in rats: A comparison of wistar and fischer 344 strains. Pharmacology, Biochemistry Behavior, 14, 827–830.

    Article  PubMed  Google Scholar 

  • Lloyd, K. G., Hornykiewicz, O., Davidson, L., Shanak, K., Farley, I., Goldstein, M., & Shibuya, M. (1981). Biochemical evidence of dysfunction of brain neurotransmitters in the Lesch-Nyhan syndrome. The New England Journal of Medicine, 305, 1106–1111.

    Article  PubMed  Google Scholar 

  • Madden, J., Akil, H., Patrick, R. L., & Barchas, J. D. (1977). Stress-induced parallel changes in central opioid levels and pain responsiveness in the rat. Nature, 265, 358–60.

    Article  PubMed  Google Scholar 

  • Maisto, C. R., Baumeister, A. A., & Maisto, A. A. (1978). An analysis of variables related to self-injurious behavior among institutionalized retarded persons. Journal of Mental Deficiency Research, 22, 27–36.

    PubMed  Google Scholar 

  • Manfredi, M., Bini, G., Cruccu, G., Accornero, N., Berardelli, A., & Medolago, L. (1981). Congenital absence of pain. Archives of Neurology, 38, 507–511.

    PubMed  Google Scholar 

  • Margolin, D. I., & Moon, B. H. (1979). Naloxone blockade of apomorphine-induced stereotyped behavior. Journal of the Neurological Sciences, 43, 13–17.

    Article  PubMed  Google Scholar 

  • Mason, W. A., (1968). Early social deprivation in nonhuman primates: Implications for human behavior. In D. C. Glass (Ed.), Environmental influences (pp. 70–101 ). New York: Rockefeller University Press.

    Google Scholar 

  • Mason, W. A., & Capitanio, J. P. (1988). Formation and experssion of filial attachment in rhesus monkeys raised with living and inanimate mother substitutes. Developmental Psychobiology, 21, 401–430.

    Article  PubMed  Google Scholar 

  • McBride, P. A., Anderson, G. N., Hertzig, M. E., Sweeney, J. A., Kream, J., Chone, D. J., & Mann, J. J. (1989). Serotonergic responsivity in male young adults with autistic disorder: Results of a pilot study. Archives of General Psychiatry, 46, 213–221.

    PubMed  Google Scholar 

  • Meyer-Holzapfel, M. (1968). Abnormal behavior in zoo animals. In F. W. Fox. (Ed.), Abnormal behavior in animals, (pp. 476–503 ). Philadelphia: W. B. Saunders.

    Google Scholar 

  • Minderaa, R. B., Anderson, G. M., Volkmar, F. R., Akkerhuis, G. W., & Cohen, D. J. (1989). Neurochemical study of dopamine functioning in autistic and normal subjects. Journal of the American Academy of Child and Adolescent Psychiatry, 28, 190–194.

    Article  PubMed  Google Scholar 

  • Mizuno, T. and Yugari, Y. (1974). Self-mutilation in the Lesch-Nyhan syndrome. Lancet, 1, 761.

    Article  PubMed  Google Scholar 

  • Mizuno, T. & Yugari, Y. (1975). Prophylactic effect of L-5 hydroxytryptophan on self-mutilation in the Lesch-Nyhan syndrome. Neuropaediatrie, 6, 13–23.

    Article  Google Scholar 

  • Mueller, K., Hollingsworth, & Petit, H. (1986). Repeated pemoline produces self-injurious behavior in adult and weanling rats. Pharmacology Biochemistry and Behavior, 25, 933–938.

    Google Scholar 

  • Mueller, K., & Nyhan, W. L. (1982a). Clonidine potentiates drug induced self-injurious behavior in rats. Pharmacology Biochemistry and Behavior, 18, 891–894.

    Article  Google Scholar 

  • Mueller, K., & Nyhan, W. L. (1982b). Pharamacologic control of pemoline induced self-injurious behavior in rats. Pharmacology Biochemistry and Behavior, 16, 957–963.

    Article  Google Scholar 

  • Mueller, K., Saboda, R., Palmour, & Nyhan, W. L. (1982). Self-injurious behavior produced in rats by daily caffeine and continuous amphetamine. Pharmacology Biochemistry and Behavior, 17, 613–617.

    Google Scholar 

  • Mulder, A. H., Wardeh, G., Hogenboom, F., & Frankhuyzen, A. L. (1984). Kappa and delta opiate receptor agonists differentially inhibit striatal dopamine and acetylcholine release. Nature, 308, 278–280.

    Article  PubMed  Google Scholar 

  • Murrin, L. C., Coyle, J. T., & Kuhar, M. J. (1980). Striatal opiate receptors: Pre and postsynaptic localization. Life Sciences, 27, 1175–1183.

    Article  PubMed  Google Scholar 

  • Naidu, S., Murphy, M., Moser, H. W., & Rett, A. (1986). Rett syndrome: Natural history in 70 cases. American Journal of Medical Genetics, 24, 61–72.

    Article  Google Scholar 

  • Nyhan, W. L. (1972). Behavioral phenotypes in organic genetic disease. (1971). Pediatric Research, 6, 1–9.

    Article  PubMed  Google Scholar 

  • Nyhan, W. L. (1976). Behavior in the Lesch-Nyhan syndrome. Journal of Autism and Childhood Schizophrenia, 6, 235–252.

    Article  PubMed  Google Scholar 

  • Nyhan, W. L., Johnson, H. G., Kaufman, I. A., & Jones, K. L. (1980). Serotonergic approaches to the modification of behavior in the Lesch-Nyhan syndrome. Applied Research in Mental Retardation, 1, 25–40.

    Article  PubMed  Google Scholar 

  • Olds, M. E., & Fobes, J. L. (1981). The central basis of motivation: Intracranial self-stimulation studies. Annual Review of Psychology, 32, 523–594.

    Article  PubMed  Google Scholar 

  • O’Neil, M. N. (1982). Effects of an anti-depressant drug given to isolate primates who display self-injurious behaviors: A comparative study. Unpublished doctoral dissertation. University of Wisconsin, Madison.

    Google Scholar 

  • Ornitz, E. M. (1974). The modulation of sensory input and motor output in autistic children. Journal of Autism and Childhood Schizophrenia, 4, 197–215.

    Article  PubMed  Google Scholar 

  • Pallard, H., Llorens, J., Schwartz, J. C., Gros, C., & Dray, F. (1978). Localization of opiate receptors and enkephalins in the rat striatum with relation to the nigrostriatal dopaminergic system: lesion studies. Brain Research, 151, 392–398.

    Article  Google Scholar 

  • Pattison, E. M., & Kahan, J. (1983). The deliberate self-harm syndrome. American Journal of Psychiatry, 140, 867–872.

    PubMed  Google Scholar 

  • Peters, J. M. (1967). Caffeine induced hemorrhagic automutilation. Archives Internationales de Pharmaco-dynamie et de Therapy, 169, 139–146.

    Google Scholar 

  • Picker, M., Poling, A., & Parker, A. (1979). A review of children’s self-injurious behavior. The Psychological Record, 29, 435–452.

    Google Scholar 

  • Randrup, A., & Munkvad, I. (1967). Stereotyped activities produced by amphetamines in several animal species and man. Psychopharmacologia, 11, 300–310.

    Article  PubMed  Google Scholar 

  • Reiss, A. L. (1988). Cerebellar hyperplasia and autism. New England Journal of Medicine, 319, 1152–1153.

    Article  Google Scholar 

  • Rett, A. (1966). Ãœber ein eigneartiges hirnatrophisches syndrom bei hyperammonamie im kindersaltger. Wein Med Wochenschr., 116, 723–726.

    Google Scholar 

  • Richardson, J. S., & Zaleski, W. A. (1983). Naloxone and self-mutilation. Biological Psychiatry, 18, 99–101.

    PubMed  Google Scholar 

  • Riederer, P., Brucke, T., Kienzl, E., Schnecker, K., Schay, V., Kruzik, P., Killian W., & Rett, A. (1985). Neurochemistry of Rett syndrome. Brain and Development, 7, 351–60.

    PubMed  Google Scholar 

  • Riley, C. M., Day, R. L., Greeley, D. M., & Langford, W. S. (1949). Central autonomic dysfunction with defective lacrimation. Pediatrics, 3, 468–478.

    PubMed  Google Scholar 

  • Ritvo, E. R., Freeman, B. J., Geller, E., & Yuwiler, A. (1983) Effects of fenfluramine on 14 autistic outpatients. Journal of the American Academy of Child Psychiatry, 22, 549–558.

    Article  PubMed  Google Scholar 

  • Russo, D. C., Carr, E. G., & Lovaas, O. I. (1980). Self-injury in pediatric populations. In J. Ferguson and C. B. Taylor (Eds.), Comprehensive handbook of behavioral medicine (Vol. 3, pp. 23–41 ). New York: Spectrum Publications.

    Google Scholar 

  • Ryan, S. M., and Maier, S. F. (1988). The estrous cycle and estrogen modulate stress induced analgesia. Behavioral Neuroscience, 102, 371–380.

    Article  PubMed  Google Scholar 

  • Rylander, G. (1971). Stereotypy in man following amphetamine abuse. In S. B. de Baker (Ed.), The correlation of adverse effects in man with observations in animals. Series No. 220, (pp. 28–31 ). Amsterdam: Excepta Medica, International Congress.

    Google Scholar 

  • Sackett, G. P. (1968). Abnormal behavior in laboratory reared rhesus monkey. In F. W. Fox (Ed.). Abnormal behaviour in animals ( 293–374 ). Philadephia: W. B. Saunders.

    Google Scholar 

  • Schroeder, S. R., Schroeder, C. S., Smith, R., & Dalldorf, J. (1978). Prevalence of self-injurious behaviors in a large state facility for the retarded: A three-year follow-up study. Journal of Autism and Childhood Schizophrenia, 8, 261–269.

    Article  PubMed  Google Scholar 

  • Shear, C. S., Nyhan, W. L., Kirman, B. H., & Stern, J. (1971). Self-mutilative behavior as a feature of the de Lange syndrome. Journal of Pediatrics, 78, 506–509.

    Article  PubMed  Google Scholar 

  • Singh, N. N., & Pulman, R. M. (1979). Self injury in the de Lange syndrome. Journal of Mental Deficiency Research, 23, 79–84.

    PubMed  Google Scholar 

  • Smeets, P. M. (1971). Some characteristics of mental defectives displaying self mutilative behaviors. Training School Bulletin. (Vineland), 68, 131–135.

    Google Scholar 

  • Snyder, S. H. (1977). Opiate receptors in the brain. New England Journal of Medicine, 296, 266–271.

    Article  PubMed  Google Scholar 

  • Stuckey, J., Marra, S., Minor, T., & Insel, T. R. (1989). Changes in mu opiate receptors following inescapable shock, Brain Research, 476, 167–169.

    Article  PubMed  Google Scholar 

  • Sutherland, G. R. (1985). Heritable fragile sites on human chromosomes: XII. Population cytogenetics. Annals of Human Genetics, 49, 153–161.

    Article  PubMed  Google Scholar 

  • Sweetman, L., & Nyhan, W. L. (1972). Further studies of the enzyme composition of mutant cells. Archives of Internal Medicine, 130, 214–220.

    Article  PubMed  Google Scholar 

  • Szymanski, L., Kedesdy, J., Sulkes, S., & Cutler, A. (1987). Naltrexone in treatment of self injurious behavior: A clinical study. Research in Developmental Disabilites, 8, 179–190.

    Article  Google Scholar 

  • Taub, E. (1976). Movement in nonhuman primates deprived of somatosensory feedback. In J. F. Keogh (Ed.), Exercise and sports sciences reviews (Vol. 4, pp. 335–376 ). Santa Barbana, CA: Journal Publishing Affiliates.

    Google Scholar 

  • Taub, E., Perrella, P. N., & Barro, G. (1973). Behavioral development following forelimb deafferentation on the day of birth in monkeys with and without blinding. Science, 81, 959–60.

    Article  Google Scholar 

  • Thrush, D. C. (1973). Congenital insensitivity to pain: A clinical, genetic, and neurophysiological study of four children from the same family. Brain, 96, 369–386.

    Article  PubMed  Google Scholar 

  • Ungerstedt, U. (1971). Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of the nigra-striatal dopamine system. Acta Physiology Scandanavia (Suppl)., 367, 69–93.

    Google Scholar 

  • Watts, R. W. E., Spellacvy, E., Gibbs, D. A., Allsop, J., McKeran, R. O., & Slavin, G. E. (1982). Clinical, postmortem, biochemical, and therapeutic observations in Lesch—Nyhan syndrome. Quarterly Journal of Medicine, 5, 73–78.

    Google Scholar 

  • Willer, J. P., Dekers, & A. Cambier, J. (1981). Stress induced analgesia in humans: Endogenous opioids and naloxone reversible suppression of pain reflexes. Science, 212, 689–691.

    Article  PubMed  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag New York, Inc.

About this chapter

Cite this chapter

Harris, J.C. (1992). Neurobiological Factors in Self-injurious Behavior. In: Luiselli, J.K., Matson, J.L., Singh, N.N. (eds) Self-injurious Behavior. Disorders of Human Learning, Behavior, and Communication. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9130-2_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-9130-2_3

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-9132-6

  • Online ISBN: 978-1-4613-9130-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics