Skip to main content

Psychopharmacology of Self-injury

  • Chapter
Self-injurious Behavior

Abstract

A long-held view of mental retardation is that it is primarily a problem of learning, and that the behavioral deficits and excesses exhibited by individuals with mental retardation can be treated through learning-based therapies. This view has led some professionals to question the need for using psychotropic medication to treat behavior problems in this population. Historically, this view may have been reinforced by the use of many ineffective and even toxic substances prior to the chlorpromazine era (Caldwell, 1978). The use of medication has been likened to a “chemical straitjacket” by some professionals who questioned whether individuals with mental retardation actually learned anything while on medication (see Aman, 1984). However, based on the “magic bullet” theory (Wolfensberger & Menolascino, 1968), others espoused the use of various drugs in the hope of reversing the intellectual deficits of individuals with mental retardation. Although the fallacy of this theory has always been very clear, individuals with mental retardation are still the single most medicated group of individuals in our society today (Singh & Winton, 1989).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Abbott, P., Blake, A., & Vincze, L. (1965). Treatment of mentally retarded with thioridazine. Diseases of the Nervous System, 26, 583–585.

    PubMed  Google Scholar 

  • Ackles, P. A. (1986). Evaluating pharmacological-behavioral treatment interactions. In M. Hersen (Ed.), Pharmacological and behavioral treatment interactions (pp. 54–86 ). New York: Wiley.

    Google Scholar 

  • Adamson, W. C., Nellis, B. P., Runge, G., Cleland, C., & Killian, E. (1958). Use of tranquilizers for mentally deficient patients. American Journal of Diseases of Children, 96, 159–164.

    Google Scholar 

  • Aman, M. G. (1984). Psychoactive drugs in mental retardation. In J. L. Matson & F. Andrasik (Eds.), Treatment issues and innovations in mental retardation (pp. 455–513 ). New York: Plenum.

    Google Scholar 

  • Aman, M. G., Field, C. J., & Bridgman, G. D. (1985). City-wide survey of drug patterns among noninstitutionalized retarded persons. Applied Research in Mental Retardation, 5, 159–171.

    Google Scholar 

  • Aman, M. G., & Singh, N. N. (1980). The usefulness of thioridazine for treating childhood disorders: Fact or folklore? American Journal of Mental Deficiency, 84, 331–338.

    PubMed  Google Scholar 

  • Aman, M. G., & Singh, N. N. (1982). Methylphenidate in severely retarded residents and the clinical significance of stereotypic behavior. Applied Research in Mental Retardation, 3, 345–358.

    PubMed  Google Scholar 

  • Aman, M. G., & Singh, N. N. (1988). Psychopharmacology of the developmental disabilities. New York: Springer-Verlag.

    Google Scholar 

  • Aman, M. G., & Singh, N. N. (1991). Pharmacological intervention: Update. In J. L. Matson & J. A. Mulick (Eds.), Handbook of mental retardation (pp. 347–373 ). New York: Pergamon.

    Google Scholar 

  • Aman, M. G., Teehan C. J., White, A. J., Turbott, S. H., & Vaithianathan, C. (1989). Haloperidol treatment with chronically medicated residents: Dose effects on clinical behavior and reinforcement contingencies. American Journal of Mental Deficiency, 93, 452–460.

    Google Scholar 

  • Aman, M. G., & White, A. J. (1988). Thioridazine dose effects with reference to stereotypic behavior in mentally retarded residents. Journal of Autism and Developmental Disabilities, 18, 355–366.

    Google Scholar 

  • Amin, P., & Yeragani, V. K. (1987). Control of aggressive and self-mutilative behavior in a mentally retarded patient with lithium. Canadian Journal of Psychiatry, 32, 162–163.

    Google Scholar 

  • Anders, T. F., Cann, H. M., Ciaranello, R. D., Barchas, J. D., & Berger, P. A. (1978). Further observations on the use of 5-hydroxytryptophan in a child with Lesch-Nyhan syndrome. Neuropediatrie, 9, 157–166.

    Google Scholar 

  • Anderson, L. T., Campbell, M., Grega, D. M., Perry, R., Small, A. M., & Green, W. H. (1984). Haloperidol in the treatment of infantile autism: Effects on learning and behavioral symptoms. American Journal of Psychiatry, 141, 1195–1202.

    PubMed  Google Scholar 

  • Anderson, L. T., Hermann, L., & Dancis, J. (1976). The effect of L-5hydroxytryptophan on self-mutilation in Lesch-Nyhan disease: A negative report. Neuropediatrie, 7, 439–442.

    Google Scholar 

  • Barrett, R. P., Feinstein, C., & Hole, W. T. (1990). Effects of naloxone and naltrexone on self-injury: A double-blind, placebo-controlled analysis. American Journal of Mental Retardation, 93, 644–651.

    Google Scholar 

  • Bates, W. J., Smeltzer, D. J., & Arnoczky, S. M. (1986). Appropriate and inappropriate use of psychotherapeutic medications for institutionalized mentally retarded persons. American Journal of Mental Deficiency, 90, 363–370.

    PubMed  Google Scholar 

  • Beckwith, B. E., Couk, D. I., & Schumacher, K. (1986). Failure of naloxone to reduce self-injurious behavior in two developmentally disabled females. Applied Research in Mental Retardation, 7, 183–188.

    PubMed  Google Scholar 

  • Berkheimer, J. L., Curtis, J. L., & Jann, M. W. (1985). Use of carbamazepine in psychiatric disorders. Clinical Pharmacy, 4, 425–434.

    Google Scholar 

  • Bernstein, G. A., Hughes, J. H., Mitchell, J. E., & Thompson, T. (1987). Effects of narcotic antagonists on self-injurious behavior: A single case study. Journal of the American Academy of Child and Adolescent Psychiatry, 26, 886–889.

    PubMed  Google Scholar 

  • Beyer, H. A. (1988). Litigation and the use of drugs in developmental disabilities. In M. G. Aman & N. N. Singh (Eds.), Psychopharmacology of the developmental disabilities (pp. 29–57 ). New York: Springer-Verlag.

    Google Scholar 

  • Briggs, R. (1989). Monitoring and evaluating psychotropic drug use for persons with mental retardation: A followup report. American Jounal of Mental Retardation, 93, 633–639.

    Google Scholar 

  • Burk, H. W., & Menolascino, F. J. (1968). Haloperidol in emotionally disturbed mentally retarded individuals. American Journal of Psychiatry, 124, 1589–1591.

    PubMed  Google Scholar 

  • Burns, M. E. (1980). Droperidol in the management of hyperactivity, self-mutilation and aggression in mentally handicapped patients. Journal of International Medical Research, 8, 31–33.

    PubMed  Google Scholar 

  • Caldwell, A. E. (1978) History of psychopharmacology. In W. G. Clark & J. Del Giudice (Eds.), Principles of psychopharmacology ( 2nd ed. ). New,York: Academic Press.

    Google Scholar 

  • Campbell, M., Adams, P., Small, A. M., Tesch, L. M., & Curren, E. L. (1988). Naltrexone in infantile autism. Psychopharmacology Bulletin, 24, 135–139.

    PubMed  Google Scholar 

  • Campbell, M., Anderson, L. T., Small, A. M., Locascio, J. J., Lynch, N. S., & Choroco, M. C. (1990). Naltrexone in autistic children: A double-blind and placebo-controlled study. Psychopharmacology Bulletin, 26, 130–135.

    PubMed  Google Scholar 

  • Chandler, M., Gualtieri, C. T., & Fahs, J. J. (1988). Other psychotropic drugs: Stimulants, antidepressants, the anxiolytics, and lithium carbonate. In M. G. Aman & N. N. Singh (Eds.), Psychopharmacology of the developmental disabilities (pp. 119–145 ). New York: Springer-Verlag.

    Google Scholar 

  • Ciaranello, R. D., Anders, T. F., Barchas, J. D., Berger, P. A., & Cann, H. M. (1976). The use of 5-hydroxytryptophan in a child with Lesch-Nyhan syndrome. Child Psychiatry and Human Development, 7, 127–133.

    PubMed  Google Scholar 

  • Cooper, A. F., & Fowlie, H. C. (1973). Control of gross self-mutilation with lithium carbonate. British Journal of Psychiatry, 122, 370–371.

    PubMed  Google Scholar 

  • Craig, C. R., & Stitzel, R. E. (1990). Modern pharmacology (3rd ed., pp. 537–538 ). Boston: Little Brown.

    Google Scholar 

  • Creese, I., Burt, D. R., & Snyder, S. H. (1976). Dopamine receptor binding predicts clinical and pharmacologic potencies of antischizophrenic drugs. Science, 192, 481–483.

    PubMed  Google Scholar 

  • Davidson, P. W., Kleene, B. M., Carroll, M., & Rockowitz, R. J. (1983). Effects of naloxone on self-injurious behavior: A case study. Applied Research in Mental Retardation, 4, 1–4.

    PubMed  Google Scholar 

  • Davis, K. V., Sprague, R. L., & Werry, J. S. (1969). Stereotyped behavior and activity level in severe retardates: The effect of drugs. American Journal of Mental Deficiency, 73, 721–727.

    PubMed  Google Scholar 

  • Dutsch, S. I. (1986). Rationale for the administration of opiate antagonists in treating infantile autism. American Journal of Mental Deficiency, 90, 631–635.

    Google Scholar 

  • Durand, V. M. (1982). A behavioral/pharmacological intervention for the treatment of severe self-injurious behavior. Journal of Autism and Developmental Disorders, 12, 243–251.

    PubMed  Google Scholar 

  • Eadie, M. J. (1987). Mode of action of anticonvulsant drugs. In G. D. Burrows, T. R. Norman, & B. Davies (Eds.), Antimanics, anticonvulsants and other drugs in psychiatry (pp. 11–129 ). Amsterdam: Elsevier.

    Google Scholar 

  • Farber, J. M. (1987). Psychopharmacology of self-injurious behavior in the mentally retarded. Journal of the American Academy of Child and Adolescent Psychiatry, 26, 296–302.

    PubMed  Google Scholar 

  • Findholt, N. E., & Emmett, C. G. (1990). Impact of interdisciplinary team review on psychotropic drug use with persons who have mental retardation. Mental Retardation, 28, 41–46.

    PubMed  Google Scholar 

  • Fox, L., & Westling, D. L. (1986). The prevalence of students who are profoundly mentally handicapped receiving medication in a school district. Education and Training of the Mentally Retarded, 21, 205–210.

    Google Scholar 

  • Frith, C.D., Johnstone, E. C., Joseph, M. H., Powell, R. J., & Watts, R. W. E. (1976). Double-blind clinical trial of 5-hydroxytryptophan in a case of LeschNyhan syndrome. Journal of Neurology, Neurosurgery, and Psychiatry, 39, 656–662.

    PubMed  Google Scholar 

  • Gadow, K. D. (1985). Prevalence and efficacy of stimulant drug use with mentally retarded children and youth. Psychopharmacology Bulletin, 21, 291–303.

    PubMed  Google Scholar 

  • Gadow, K. D., & Poling, A. G. (1988). Pharmacotherapy and mental retardation. Boston: College-Hill.

    Google Scholar 

  • Galambos, M. (1965). Long term clinical trial with diazepam on adult mentally retarded persons. Diseases of the Nervous System, 26, 305–309.

    PubMed  Google Scholar 

  • Gillman, M. A., & Sandyk, R. (1985). Opiatergic and dopaminergic function and Lesch-Nyhan syndrome. American Journal of Psychiatry, 142, 1226.

    PubMed  Google Scholar 

  • Golden, G. S. (1988). Tardive dyskinesia and developmental disabilities. In M. G. Aman & N. N. Singh (Eds.), Psychopharmacology of the developmental disabilities (pp. 179–215 ). New York: Springer-Verlag.

    Google Scholar 

  • Goldstein, M. (1989). Dopaminergic mechanisms in self-inflicting biting behavior. Psychopharmacology Bulletin, 25, 349–352.

    PubMed  Google Scholar 

  • Goldstein, M., Anderson, L. T., Reuben, R., & Dancis, J. (1985). Self-mutilation in Lesch-Nyhan disease is caused by dopaminergic denervation. Lancet, 1, 338–339.

    PubMed  Google Scholar 

  • Grabowski, S. W. (1973). Safety and effectiveness of haloperidol for mentally retarded behaviorally disordered and hyperkinetic patients. Current Therapeutic Research, 15, 856–861.

    PubMed  Google Scholar 

  • Grossett, D. L., Williams, D. E. ( 1988, May). Psychopharmacological intervention for the treatment of self-injurious behavior in a person with profound mental retardation and a psychiatric disorder. Paper presented at the annual convention of the Association for Behavior Analysis, Philadelphia.

    Google Scholar 

  • Haegeman, J., & Duyck, F. (1978). A retrospective evaluation of pipamperon (Dipiperon) in the treatment of behavioral deviations in severely mentally handicapped. Acta Psychiatrica Belgica, 78, 392–398.

    PubMed  Google Scholar 

  • Heistad, G. T., Zimmerman, T. L., & Doebler, M. I. (1982). Long-term usefulness of thioridazine for institutionalized mentally retarded patients. American Journal of Mental Deficiency, 87, 243–251.

    PubMed  Google Scholar 

  • Herman, B. H., Hammock, M. K., Arthur-Smith, A., Egan, J., Chatoor, I., Werner, A., & Boeckx, R. L. (1986). Role of opioid peptides in self-injurious behavior. Society for Neuroscience Abstracts, 12, 412.

    Google Scholar 

  • Herman, B. H., Hammock, M. K., Arthur-Smith, A., Egan, J., Chatoor, I., Werner, A., & Zelnick, N. (1987). Naltrexone decreases self-injurious behavior. Annals of Neurology, 22, 550–552.

    PubMed  Google Scholar 

  • Herman, B. H., Hammock, M. K., Egan, J., Feinstein, C., Chatoor, I., Boeckx, R., Zelnick, N., Jack, R., & Rosenquist, J. (1985). Naltrexone induces dose-dependent decreases in self-injurious behavior. Society for Neuroscience Abstracts, 11, 468.

    Google Scholar 

  • Hill, B. K., Balow, E. A., & Bruininks, R. H. (1985). A national survey of prescribed drugs in institutions and community residential facilities for mentally retarded people. Psychopharmacology Bulletin, 21, 279–284.

    PubMed  Google Scholar 

  • Holaday, J. W. (1985). Endogenous opioids and their receptors. Kalamazoo: Upjohn.

    Google Scholar 

  • Huessy, H. R., & Ruoff, P. A. (1984). Towards a rational drug usage in a state institution for retarded individuals. Psychiatric Journal of the University of Ottawa, 9, 56–58.

    PubMed  Google Scholar 

  • Insel, T. R., Ninan, P. T., Aloi, J., Jimerson, D.C., Skolnick, P., & Paul, S. M. (1984). A benzodiazepine receptor-medicated model of anxiety. Archives of General Psychiatry, 41, 741–750.

    PubMed  Google Scholar 

  • Intagliata, J., & Rinck, C. (1985). Psychoactive drug use in public and community residential facilities for mentally retarded persons. Psychopharmacology Bulletin, 21, 268–278.

    PubMed  Google Scholar 

  • Iwata, B. A., Vollmer, T. R., & Zarcone, J. R. (1990). The experimental (functional) analysis of behavior disorders: Methodology, applications, and limitations. In A. C. Repp & N. N. Singh (Eds.), Perspectives on the use of nonaversive and aversive interventions for persons with developmental disabilities (pp. 301–330 ). Sycamore, IL: Sycamore Publishing.

    Google Scholar 

  • Jakab, I. (1984). Short-term effect of thioridazine tablet versus suspension on emotionally disturbed/retarded children. Journal of Clinical Psychopharmacology, 4, 210–215.

    PubMed  Google Scholar 

  • Janicak, P. G., & Vadis, J. M. (1987). Clinical usage of lithium in mania. In G. D. Burrows, T. R. Norman, & B. Davies (Eds.), Antimanics, anticonvulsants and other drugs in psychiatry (2nd ed., Vol. 7, pp. 46–74 ). New York: Basic Books.

    Google Scholar 

  • Jenkins, S. C., & Maruta, T. (1987), Therapeutic use of propranolol for intermittent explosive disorder. Mayo Clinic Proceedings, 62, 204–214.

    PubMed  Google Scholar 

  • Konicki, P. E., & Schulz, S. C. (1989). Rationale for clinical trials of opiate antagonists in treating patients with personality and self-injurious behavior. Psychopharmacology Bulletin, 25, 556–563.

    PubMed  Google Scholar 

  • Lacny, J. (1973). Mesoridazine in the care of disturbed mentally retarded patients. Canadian Psychiatric Association Journal, 18, 389–391.

    PubMed  Google Scholar 

  • Langee, H. R. (1989). A retrospective study of mentally retarded patients with behavioral disorders who were treated with carbamazepine. American Journal of Mental Deficiency, 93, 640–643.

    Google Scholar 

  • LeBoyer, M., Bouvard, M. P., & Dugas, M. (1988). Effects of naltrexone on infantile autism. Lancet, 1, 715.

    PubMed  Google Scholar 

  • Lehne, R. A. (1990). Pharmacology for nursing care. Philadelphia: W. B. Saunders.

    Google Scholar 

  • Le Vann, L. J. (1969). Haloperidol in the treatment of behavioral disorders in children and adolescents. Canadian Psychiatric Association Journal, 14, 217–220.

    Google Scholar 

  • Lewis, M. H., & Mailman, R. B. (1988). Drug blood levels: Measurement and relation to behavioral outcome in mentally retarded persons. In M. G. Aman & N. N. Singh (Eds.), Psychopharmacology of the developmental disabilities (pp. 58–81 ). New York: Springer-Verlag.

    Google Scholar 

  • Lipman, R. S. (1970). The use of psychopharmacological agents in residential facilities for the retarded. In F. J. Menolascino (Ed.), Psychiatric approaches to mental retardation (pp 387–398 ). New York: Basic Books.

    Google Scholar 

  • Llorente, A. F. (1969). The management of behavior disorders with thioridazine in the mentally retarded. Journal of the Maine Medical Association, 60, 229–231.

    PubMed  Google Scholar 

  • Luchins, D. J., & Dojka, D. (1989). Lithium and propranolol in aggression and self-injurious behavior in the mentally retarded. Psychopharmacology Bulletin, 25, 372–375.

    PubMed  Google Scholar 

  • Luiselli, J. K. (1986). Behavior analysis of pharmacological and contingency management interventions for self-injury. Journal of Behavior Therapy and Experimental Psychiatry, 17, 275–284.

    PubMed  Google Scholar 

  • Luiselli, J. K., Beltis, J. A., & Bass, J. (1989). Clinical analysis of naltrexone in the treatment of self-injurious behavior. Journal of the Multihandicapped Person, 2, 43–50.

    Google Scholar 

  • Luiselli, J. K., & Evans, T. P. (1987). Assessing pharmacological and contingency management interventions with mentally retarded adolescents in a residential treatment program. Behavioral Residential Treatment, 2, 139–152.

    Google Scholar 

  • Luiselli, J. K., Evans, T. P., & Boyce, D. A. (1986). Pharmacological assessment and comprehensive behavioral intervention in a case of pediatric self-injury. Journal of Clinical Child Psychology, 15, 323–326.

    Google Scholar 

  • Malseed, R. T., & Harrigan, G. S. (1989). Textbook of pharmacology and nursing care. Philadelphia: J. B. Lippincott.

    Google Scholar 

  • Marholin, D., Touchette, P. E., & Stewart, R. M. (1979). Withdrawal of chronic chlorpromazine medication: An experimental analysis. Journal of Applied Behavior Analysis, 12, 159–271.

    PubMed  Google Scholar 

  • Martin, J. E., & Argran, M. (1985). Psychotropic and anticonvulsant drug use by mentally retarded adults across community residential and vocational placements. Applied Research in Mental Retardation, 6, 33–49.

    PubMed  Google Scholar 

  • Martin, W. R., Jasinski, D. R., & Mansky, P. A. (1984). Naltrexone, an antagonist for the treatment of heroin dependence: Effects in man. Archives of General Psychiatry, 28, 784–791.

    Google Scholar 

  • Micev, V., & Lynch, D. M. (1974). Effect of lithium on disturbed severely mentally retarded patients. British Journal of Psychiatry, 125, 110.

    PubMed  Google Scholar 

  • Mikkelsen, E. J. (1986). Low dose haloperidol for stereotypic self-injurious behavior in the mentally retarded. New England Journal of Medicine, 315, 398–399.

    PubMed  Google Scholar 

  • Millichamp, C. J., & Singh, N. N. (1987). The effects of intermittent drug therapy on stereotypy and collateral behaviors of mentally retarded persons. Research in Developmental Disabilities, 8, 213–227.

    PubMed  Google Scholar 

  • Mizuno, T., & Yugari, Y. (1974). Self-mutilation in Lesch-Nyhan syndrome. Lancet, 1, 761.

    PubMed  Google Scholar 

  • Mizuno, T., & Yugari, Y. (1975). Prophylactic effects of L-5-hydroxytryptophan on self-mutilation in the Lesch-Nyhan syndrome. Neuropadiatrie, 6, 13–23.

    Google Scholar 

  • Mouchka, S. (1985). Issues in psychopharmacology with the mentally retarded. Psychopharmacology Bulletin, 21, 262–267.

    PubMed  Google Scholar 

  • National Institute of Mental Health. (1989). Draft report of the consensus development panel on treatment of destructive behaviors in persons with developmental disabilities. Washington, DC: Author.

    Google Scholar 

  • Naylor, G. J., Dick, D. A. T., Dick, E. G., & Moody, J. P. (1974). Lithium therapy and erythrocyte membrane cation carrier. Psychopharmacology, 3, 81–86.

    Google Scholar 

  • Nyhan, W. L. (1976). Behavior inh the Lesch-Nyhan syndrome. Journal of Autism and Childhood Schizophrenia, 6, 235–252.

    PubMed  Google Scholar 

  • Nyhan, W. L., Johnson, H. G., Kaufman, I. A., & Jones, K. L. (1980). Serotonergic approaches to the modification of behavior in the Lesch-Nyhan syndrome. Applied Research in Mental Retardation, 1, 25–40.

    PubMed  Google Scholar 

  • O’Neil, R. E., Homer, R. H., Albin, R. W., Storey, K., & Sprague, J. R. (1990). Functional analysis of problem behavior: A practical assessment guide. Sycamore, IL: Sycamore Publishing.

    Google Scholar 

  • Ortiz, A., Dabbagh, M., & Gershon, S. (1984). Lithium: Clinical use, toxicology and mode of action. In J. C. Bernstein (Ed.), Clinical psychopharmacology (pp. 111–144 ). Boston: John Wright PSG.

    Google Scholar 

  • Peet, M. (1981). Is propranolol antischizophrenic? Neuropharmacology, 20, 1303–1307.

    PubMed  Google Scholar 

  • Poindexter, A. R. (1989). Psychotropic drug patterns in a large ICF/MR facility: A ten-year experience. American Journal of Mental Retardation, 93, 624–626.

    PubMed  Google Scholar 

  • Polakoff, S. A., Sorgi, P. J., & Ratey, J. J. (1986). The treatment of impulsive and aggressive behavior with nadolol. Journal of Clinical Psychopharmacology, 6, 125–126.

    PubMed  Google Scholar 

  • Primrose, D. A. (1979). Treatment of self-injurious behavior with la GABA (gamma-aminobutyric acid) analogue. Journal of Mental Deficiency Research, 23, 163–173.

    PubMed  Google Scholar 

  • Ratey, J. J., Mikkelsen, E. J., Smith, B., Upadhyaya, A., Zuckerman, S., Martell, D., Sorgi, P., Polakoff, S., & Bemporad, J. (1986). Beta-blockers in the severely and profoundly mentally retarded. Journal of Clinical Psycho-pharmacology, 6, 103–107.

    Google Scholar 

  • Ratey, J. J., Mikkelsen, E., sorgi, P., Zuckerman, S., Polakoff, S., Bemporad, J., Bick, P., & Kadish, W. (1987). Autism: The treatment of aggressive behaviors. Journal of Clinical Psychopharmacology, 7, 35–41.

    PubMed  Google Scholar 

  • Ratey, J. J., Morrill, R., & Oxenkrug, G. (1983). Use of propranolol for provoked and unprovoked episodes of rage. American Journal of Psychiatry, 140, 1356–1357.

    PubMed  Google Scholar 

  • Reid, A. H., Naylor, G. J., & Kay, D. S. G. (1981). A double-blind, placebo controlled crossover trial of carbamazepine in overactive severely mentally handicapped patients. Psychological Medicine, 11, 109–113.

    PubMed  Google Scholar 

  • Repp, A. C., Felce, D., & Barton, L. E. (1988). Basing the treatment of stereotypic and self-injurious behaviors on hypotheses of their causes. Journal of Applied Behavior Analysis, 21, 281–289.

    PubMed  Google Scholar 

  • Repp, A. C., & Singh, N. N. (1990). Perspectives on the use of nonaversive and aversive interventions for persons with developmental disabilities. Sycamore, IL: Sycamore Publishing.

    Google Scholar 

  • Richardson, J. S., & Zaleski, W. A. (1983). Naloxone and self-mutilation. Biological Psychiartry, 18, 99–101.

    Google Scholar 

  • Richardson, J. S., & Zaleski, W. A. (1986a). Endogenous opiates and self-mutilation. American Journal of Psychiatry, 143, 939.

    Google Scholar 

  • Richardson, J. S., & Zaleski, W. A. (1986b). On the role of endogenous opioids in the maintenance of self-mutilation. International Journal of Neuroscience, 31, 129.

    Google Scholar 

  • Ritrovato, C. A., Weber, S. S., & Dufresne, R. L. (1989). Nadolol in the treatment of aggressive behavior associated with schizophrenia. Clinical Pharmacy, 8, 132–135.

    PubMed  Google Scholar 

  • Ruedrich, S. L., Grush, L., & Wilson, J. (1990). Beta adrenergic blocking medications for aggressive or self-injurious mentally retarded persons. American Journal of Mental Retardation, 95, 110–119.

    PubMed  Google Scholar 

  • Sandman, C. A., Barron, J., & Colman, H. (1990). An orally administered opiate blocker, naltreoxone, attenuates self-injurious behavior. American Journal of Mental Retardation, 95, 93–102.

    PubMed  Google Scholar 

  • Sandman, C. A., Datta, P. C., Barron, J., Hoehler, F. K., Williams, C., & Swanson, J. M. (1983). Naloxone attenuates self-abusive behavior in developmentally disabled clients. Applied Research in Mental Retardation, 4, 5–11.

    PubMed  Google Scholar 

  • Sandyk, R. (1985). Naloxone abolishes self-injury in a mentally retarded child. Annals of Neurology, 17, 520.

    PubMed  Google Scholar 

  • Schauf, D. L., Davis, F. A., & Marder, J. (1974). Effects of carbamazepine on the ionic conductances of Myxicola giant axons. Journal of Pharmacology and Experimental Therapeutics, 189, 538–542.

    PubMed  Google Scholar 

  • Schroeder, S. R. (1985). Issues and future research directions of pharmaco- therapy in mental retardation. Psychopharmacology Bulletin, 21, 323–326.

    PubMed  Google Scholar 

  • Schroeder, S. R. (1988). Neuroleptic medications for persons with developmental disabilities. In M. G. Aman and N. N. Singh (Eds.), Psychopharmacology of the developmental disabilities (pp. 82–100 ). New York: Springer-Verlag.

    Google Scholar 

  • Schroeder, S. R., & Gualtieri, C. T. (1985). Behavioral interactions induced by chronic neuroleptic therapy in persons with mental retardation. Psycho-pharmacology Bulletin, 21, 310–315.

    Google Scholar 

  • Schroeder, S. R., Lewis, M. H., & Lipton, M. A. (1983). Interactions of pharmacotherapy and behavior therapy among children with learning and behavioral disorders. In K. D. Gadow (Ed.), Advances in learning and behavioral disabilities (Vol. 2, pp. 179–225 ). Greenwich, CT: JAI Press.

    Google Scholar 

  • Schroeder, S. R., Rojahn, J., Hawk, B., Kanoy, R. C., Thios, S. J., Mulick, J. A., & Stephens, M. (1982). Environmental antecedents which affect management and maintenance of programs for self-injurious behavior. In J. H. Hollis & C. E. Meyers (eds.), Life threatening behaviors: Analysis and intervention (pp. 105–159 ). Washington, DC: American Association on Mental Deficiency.

    Google Scholar 

  • Schroeder, S. R., Rojahn, J., Mulick, J. A., & Schroeder, C. S. (1990). Self-injurious behavior. In J. L. Matson (Ed.), Handbook of behavior modification with the mentally retarded ( 2nd ed., pp. 141–180 ). New York: Plenum Press.

    Google Scholar 

  • Silver, J. M., & Yudofsky, S. C. (1985). Propranolol for aggression: Literature review and clinical guidelines. International Drug Therapy News, 20, 9–12.

    Google Scholar 

  • Silver, J. M., Yudofsky, S. C., Kogan, M., & Katz, B. L. (1986). Elevation of thioridazine plasma levels by propranolol. American Journal of Psychiatry, 143, 1290–1292.

    PubMed  Google Scholar 

  • Singh, N. N. (1981). Current trends in the treatment of self-injurious behavior. In L. A. Barness (Ed.), Advances in pediatrics (Vol. 28, pp. 377–440 ). Chicago: Year Book Medical Publishers.

    Google Scholar 

  • Singh, N. N., & Aman, M. G. (1981). Effects of thioridazine dosage on the behavior of severely mentally retarded persons. American Journal of Mental Deficiency, 85, 580–587.

    PubMed  Google Scholar 

  • Singh, N. N., & Aman, M. G. (1990). Ecobehavioral assessment of pharmacotherapy. In S. Schroeder (Ed.), Ecobehavioral analysis in developmental disabilities (pp. 182–200 ). New York: Springer-Verlag.

    Google Scholar 

  • Singh, N. N., & Beale, I. L. (1986). Behavioral assessment of pharmaeotherapy. Behavior Change, 3, 34–40.

    Google Scholar 

  • Singh, N. N., & Millichamp, C. J. (1985). Pharmacological treatment of self-injurious behavior in mentally retarded persons. Journal of Autism and Developmental Disorders, 15, 257–267.

    PubMed  Google Scholar 

  • Singh, N. N., Parmelee, D. X., Sood, A., & Katz, R. (in press). Collaboration of disciplines. In J. L. Matson (Ed.), Handbook of hyperactivity in children. New York: Pergamon Press.

    Google Scholar 

  • Singh, N. N., & Repp, A. C. (1988). Current trends in the behavioral and psychopharmacological management of problem behaviors of mentally retarded persons. Irish Journal of Psychology, 9, 362–384.

    Google Scholar 

  • Singh, N. N., Sood, A., Sonenklar, N., & Ellis, C. R. (1991). Assessment and diagnosis of mental illness in persons with mental retardation: Methods and measures. Behavior Modification, 15, 418–442.

    Google Scholar 

  • Singh, N. N., & Winton, A. S. W. (1984). Behavioral monitoring of pharmacological interventions for self-injury. Applied Research in Mental Retardation, 5, 161–170.

    PubMed  Google Scholar 

  • Singh, N. N., & Winton, A. S. W. (1989). Behavioral pharmacology. In J. K. Luiselli (Ed.), Behavioral medicine and developmental disabilities (pp. 152179 ). New York: Springer-Verlag.

    Google Scholar 

  • Skolnick, P., & Paul, S. M. (1983). New concepts in the neurobiology of anxiety. Journal of Clinical Psychiatry, 44, 12–20.

    PubMed  Google Scholar 

  • Snyder, S. H. (1981). Dopamine receptors, neuroleptics and schizophrenia. American Journal of Psychiatry, 138, 460–464.

    PubMed  Google Scholar 

  • Sokol, M. S., & Campbell, M. (1988). Novel psychoactive agents in the treatment of developmental disorders. In M. G. Aman & N. N. Singh (Eds.), Psycho-pharmacology of the developmental disabilities (pp. 146–167 ). New York: Springer-Verlag.

    Google Scholar 

  • Sorgi, P., Ratey, J., & Polakoff, S. (1987). Beta-adrenergic blockers for aggressive behavior in schizophrenia. American Journal of Psychiatry, 144, 539. Letter.

    Google Scholar 

  • Sovner, R., & Hurley, A. (1981). The management of chronic behavior disorders in mentally retarded adults with lithium carbonate. Journal of the Nervous and Mental Disease, 169, 191–195.

    Google Scholar 

  • Sprague, R. L., & Werry, J. S. (1971). Methodology of psychopharmacological studies with the retarded. In N. R. Ellis (Ed.), International review of research in mental retardation (pp. 147–210 ). New York: Academic Press.

    Google Scholar 

  • Stone, R. K., Alvarez, W. F., Ellman, G., Hom, A. C., & White, J. F. (1989). Prevalence and prediction of psychotropic drug use in California developmental centers. American Journal of Mental Retardation, 93, 627–632.

    PubMed  Google Scholar 

  • Stores, G. (1988). Antiepileptic drugs. In M. G. Aman & N. N. Singh (Eds.), Psychopharmacology of the developmental disabilities (pp. 101–118 ). New York: Springer-Verlag.

    Google Scholar 

  • Szymanski, L., Kedesdy, J., Sulkes, S., Cutler, A., & Stevens-Orr, P. (1987). Naltrexone in the treatment of self-injurious behavior: A clinical study. Research in Developmental Disabilities, 8, 179–190.

    PubMed  Google Scholar 

  • Tesar, G. E. (1982). The role of stimulants in general medicine. Drug Therapy, 12, 186–193.

    Google Scholar 

  • Tu, J., & Smith, J. T. (1983). The Eastern Ontario survey: A study of drug-treated psychiatric problems in the mentally handicapped. Canadian Journal of Psychiatry, 28, 270–276.

    Google Scholar 

  • Tyrer, S. P., Walsh, A., Edwards, D. E., Berney, T. P., & Stephens, D. A. (1984). Factors associated with a good response to lithium in aggressive mentally handicapped subjects. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 8, 751–755.

    PubMed  Google Scholar 

  • Vaisanen, K., Kainulainen, P., Paavilainen, M. T., & Viukari, M. (1975). Sulpiride versus chlorpromazine and placebo in the treatment of restless mentally subnormal patients: A double-blind crossover study. Current Therapeutic Research, 17, 202–205.

    PubMed  Google Scholar 

  • Vaisanen, K., Rimon, R., Raisanen, P., & Viukari, M. (1979). A controlled double-bling study of haloperidol versus thioridazine in the treatment of restless mentally subnormal patients: Serum levels and clinical effects. Acta Psychiatrica Belgica, 79, 673–685.

    PubMed  Google Scholar 

  • Vaisanen, K., Viukari, M., Rimon, R., & Raisanen, P. (1981). Haloperidol, thioridazine and placebo in mentally subnormal patients: Serum levels and clinical effects. Acta Psychiatrica Scandinavica, 63, 262–271.

    PubMed  Google Scholar 

  • van Praag, H. M. (1980). Central monoamine metabolism in depression. Comprehensive Psychiatry, 21, 30–54.

    PubMed  Google Scholar 

  • Varga, E., & Simpson, G. M. (1971). Loxapine succinate in the treatment of uncontrollable destructive behavior. Current Therapeutic Research, 13, 737–742.

    PubMed  Google Scholar 

  • Walters, A. S., Barrett, R. P., Feinstein, C., Mercurio, A., & Hole, W. (1990). The treatment of self-injury and social withdrawal in autism with naltrexone. Journal of Autism and Developmental Disabilities, 20, 169–176.

    Google Scholar 

  • Werry, J. S. (1982). Pharmacotherapy. In B. B. Lahey & A. E. Kazdin (Eds.), Advances in clinical child psychology (Vol. 5, pp. 283–321 ). New York: Plenum Press.

    Google Scholar 

  • Whitman, J. R., Maier, C. J., & Eichelman, B. (1987). Beta-adrenergic blockers for aggressive behavior in schizophrenia. American Journal of Psychiatry, 144, 538. Letter.

    Google Scholar 

  • Wolfensberger, W., & Menolascino, F. (1968). Basic considerations in evaluating the ability of drugs to stimulate cognitive development in retardates. American Journal of Mental Deficiency, 73, 414–423.

    PubMed  Google Scholar 

  • Woods, P. B., & Robinson, M. L. (1981). An investigation of the comparative liposolubilities of beta-adrenoceptor blocking agents. Journal of Pharmacy and Pharmacology, 33, 172–173.

    PubMed  Google Scholar 

  • Yudofsky, S., Williams, D., & Gorman, J. (1981). Propranolol in the treatment of rage and violent behavior in patients with chronic brain syndromes. American Journal of Psychiatry, 138, 218–220.

    PubMed  Google Scholar 

  • Zaleski, W. A. (1970). Clinical evaluation of mesoridazine in mentally retarded patients. Canadian Psychiatric Association Journal, 15, 319–322.

    PubMed  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag New York, Inc.

About this chapter

Cite this chapter

Singh, N.N., Singh, Y.N., Ellis, C.R. (1992). Psychopharmacology of Self-injury. In: Luiselli, J.K., Matson, J.L., Singh, N.N. (eds) Self-injurious Behavior. Disorders of Human Learning, Behavior, and Communication. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9130-2_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-9130-2_12

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-9132-6

  • Online ISBN: 978-1-4613-9130-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics