Interleukin-2 Receptors on Monocytes and Their Relation to the Process of Monocytic Cell Differentiation

  • S. Ruhl
  • G. C. Begley
  • M. Bickel
  • H. Pluznik
Conference paper
Part of the Experimental Hematology Today—1989 book series (HEMATOLOGY, volume 1989)


Resting T lymphocytes when activated by exposure to antigen or mitogen induce and amplify their own proliferation by producing a glycoprotein hormone called T cell growth factor or inteiieukin 2 (IL2) [1]. One of the classical markers of activated T cells is the subseqent expression of specific membrane receptors for interleukin 2 (IL2R) [2]. The expression of these receptors on T cells was shown to be a transient event [3] and restimulation with either antigen or mitogen is required for continous IL2R expression and maintainance of T cell proliferative capacity.


Monocytic Cell IL2R Expression Human Peripheral Blood Monocyte Mature Macrophage Cell Proliferative Capacity 
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Copyright information

© Springer-Verlag New York Inc. 1990

Authors and Affiliations

  • S. Ruhl
  • G. C. Begley
  • M. Bickel
  • H. Pluznik

There are no affiliations available

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